Top 100 The Binding of Isaac Videos With The Most Comments by SuperMegaTop 100 » 200 » 300 » 400 » 500Video TitleCommentsCategoryGame1.SuperMega Plays BINDING OF ISAAC - EP 1: Why Cockroaches Are Gross1,053Let's PlayThe Binding of Isaac 2.SuperMega Plays BINDING OF ISAAC - EP 6: Starring Ryan’s Mom298Let's PlayThe Binding of Isaac 3.SuperMega Plays BINDING OF ISAAC - EP 4: Mom Apologies257Let's PlayThe Binding of Isaac 4.SuperMega Plays BINDING OF ISAAC - EP 2: Sad Guitar Lesson248Let's PlayThe Binding of Isaac 5.SuperMega Plays BINDING OF ISAAC - EP 5: Big Words234Let's PlayThe Binding of Isaac 6.SuperMega Plays BINDING OF ISAAC - EP 3: LeVar Burton Alarm222Let's PlayThe Binding of Isaac Top 100 » 200 » 300 » 400 » 500