| 301. | How I Got C SECTION In 1.49 Seconds | 390 | | The Binding of Isaac: Rebirth
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| 302. | The Most DEVIOUS Character Ever | 390 | | The Binding of Isaac: Rebirth
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| 303. | I Finally Found GOLDEN Rock Bottom | 390 | | The Binding of Isaac: Rebirth
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| 304. | They Added A Carpet Bomb Synergy to Isaac | 390 | | The Binding of Isaac: Rebirth
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| 305. | This Is The Most Satisfying Synergy EVER | 389 | | The Binding of Isaac: Rebirth
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| 306. | Weakest Mattman Run | 388 | | The Binding of Isaac: Rebirth
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| 307. | The FASTEST Gamebreak EVER | 388 | | The Binding of Isaac: Rebirth
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| 308. | I Played As The Most SATISFYING Character Ever | 387 | | The Binding of Isaac: Rebirth
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| 309. | They Made Money = Luck. It's insane. | 386 | | The Binding of Isaac: Rebirth
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| 310. | I Have NEVER Seen This In 2 Years of Isaac | 386 | | The Binding of Isaac: Rebirth
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| 311. | How One Item Gave Me INFINITE Damage: | 386 | | The Binding of Isaac: Rebirth
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| 312. | This Synergy Makes You Literally INVINCIBLE | 386 | | The Binding of Isaac: Rebirth
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| 313. | This Character Has A LITERAL Dog | 386 | | The Binding of Isaac: Rebirth
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| 314. | This Eden's Blessing Start Was SO SATISFYING | 385 | | The Binding of Isaac: Rebirth
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| 315. | This NEW Sacred Heart Is Cursed | 385 | | The Binding of Isaac: Rebirth
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| 316. | These NEW Alternate Characters Are Simply Amazing | 384 | | The Binding of Isaac: Rebirth
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| 317. | I Found The Most Beautiful Synergy EVER | 384 | | The Binding of Isaac: Rebirth
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| 318. | They Added Grey Baby. He's PERFECT. | 384 | | The Binding of Isaac: Rebirth
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| 319. | We Fixed The WORST Item In Isaac... | 383 | | The Binding of Isaac: Rebirth
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| 320. | The RAREST Planetarium Items In The Game? | 382 | | The Binding of Isaac: Rebirth
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| 321. | The NEW Character That Crashed My Game | 382 | | The Binding of Isaac: Rebirth
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| 322. | So They BUFFED Dataminer... It was a mistake. | 382 | | The Binding of Isaac: Rebirth
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| 323. | They Added A NEW Final Boss. It's impossible. | 381 | | The Binding of Isaac: Rebirth
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| 324. | The Time I "Beta Tested" the New Isaac Update | 381 | | The Binding of Isaac: Rebirth
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| 325. | These New Synergies Are INCREDIBLE | 381 | | The Binding of Isaac: Rebirth
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| 326. | This NEW Item Gives Crazy Brimstone Synergies | 380 | | The Binding of Isaac: Rebirth
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| 327. | They Made Isaac Items 3D!! | 379 | | The Binding of Isaac: Rebirth
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| 328. | These New Final Bosses Are WILD | 379 | | The Binding of Isaac: Rebirth
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| 329. | This Item Gave Me The FUNNIEST Start Of The Year | 378 | | The Binding of Isaac: Rebirth
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| 330. | The New Character Is Actually INSANE | 377 | | The Binding of Isaac: Rebirth
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| 331. | I Got The BEST Angel Run EVER | 377 | | The Binding of Isaac: Rebirth
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| 332. | Golden Kamikaze COMPLETELY Broke My Game | 376 | | The Binding of Isaac: Rebirth
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| 333. | This New Item Gives You INFINITE Tears | 374 | | The Binding of Isaac: Rebirth
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| 334. | Least Powerful Modded Character | 374 | | The Binding of Isaac: Rebirth
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| 335. | I Achieved EDMUND Levels Of Luck | 373 | | The Binding of Isaac: Rebirth
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| 336. | How I Got TWISTED PAIR in 1.47 Seconds | 372 | | The Binding of Isaac: Rebirth
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| 337. | LUCKIEST Secret Room Possible | 372 | | The Binding of Isaac: Rebirth
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| 338. | This New Character Has INSANE Synergies | 371 | | The Binding of Isaac: Rebirth
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| 339. | The Lost, But Even HARDER | 371 | | The Binding of Isaac: Rebirth
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| 340. | The Luckiest Isaac Run Possible? | 371 | | The Binding of Isaac: Rebirth
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| 341. | The D6 Just Got A CRAZY Upgrade: | 371 | | The Binding of Isaac: Rebirth
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| 342. | This Mod Changes EVERYTHING!! | 371 | | The Binding of Isaac: Rebirth
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| 343. | Luckiest BASEMENT Ever | 370 | | The Binding of Isaac: Rebirth
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| 344. | Isaac's NEW Difficulty Is Completely: | 369 | | The Binding of Isaac: Rebirth
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| 345. | These Tainted Items Are BROKEN | 369 | | The Binding of Isaac: Rebirth
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| 346. | Most Damage Possible? | 369 | | The Binding of Isaac: Rebirth
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| 347. | Most Satisfying Shot | 369 | | The Binding of Isaac: Rebirth
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| 348. | First Floor Moment | 369 | | The Binding of Isaac: Rebirth
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| 349. | Isaac Rigged Moment | 368 | | The Binding of Isaac: Rebirth
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| 350. | How To INSTANTLY Break Isaac | 368 | Guide | The Binding of Isaac: Rebirth
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| 351. | This NEW Modded Floor Is CRAZY | 367 | | The Binding of Isaac: Rebirth
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| 352. | How I Beat Ultra Hard | 367 | | The Binding of Isaac: Rebirth
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| 353. | These New Hearts Give You INFINITE Stats | 365 | | The Binding of Isaac: Rebirth
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| 354. | Least Lucky Mattman Run: | 365 | | The Binding of Isaac: Rebirth
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| 355. | This NEW Tech Item Is Crazy | 364 | | The Binding of Isaac: Rebirth
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| 356. | World's Smallest Isaac Character | 364 | | The Binding of Isaac: Rebirth
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| 357. | I Found The CRAZIEST New Sword | 364 | | The Binding of Isaac: Rebirth
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| 358. | This NEW Demon Character Evolves!! | 364 | | The Binding of Isaac: Rebirth
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| 359. | The Sword That INSTANTLY Broke My Game | 364 | | The Binding of Isaac: Rebirth
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| 360. | This NEW Item Gives You An Isaac Armada: | 362 | | The Binding of Isaac: Rebirth
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| 361. | They Added A NEW Rock Bottom | 362 | | The Binding of Isaac: Rebirth
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| 362. | The New R Key Is ACTUALLY Broken | 362 | | The Binding of Isaac: Rebirth
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| 363. | Playing As Dogma is Simply Amazing | 361 | | The Binding of Isaac: Rebirth
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| 364. | How I Got INFINITE Stats In Under 10 Seconds | 361 | | The Binding of Isaac: Rebirth
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| 365. | How I Unlocked Tainted Keeper | 361 | | The Binding of Isaac: Rebirth
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| 366. | This New Synergy Is CRAZY | 360 | | The Binding of Isaac: Rebirth
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| 367. | Unlocking Mega Blast | 359 | | The Binding of Isaac: Rebirth
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| 368. | Tainted Mastema Is AMAZING | 359 | | The Binding of Isaac: Rebirth
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| 369. | They Turned EVERYTHING Into Godhead | 358 | | The Binding of Isaac: Rebirth
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| 370. | Skimmed Milk Is Literally Perfect | 357 | | The Binding of Isaac: Rebirth
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| 371. | Playing As The Lamb Is INCREDIBLE | 356 | | The Binding of Isaac: Rebirth
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| 372. | They Made Mongo Baby A Character. He's INSANE | 355 | | The Binding of Isaac: Rebirth
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| 373. | They Added MINECRAFT To Isaac!! | 355 | | The Binding of Isaac: Rebirth
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| 374. | This Floor ONLY Had Quality 4 Items: | 355 | | The Binding of Isaac: Rebirth
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| 375. | Unlocking Dead God | 355 | | The Binding of Isaac: Rebirth
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| 376. | This Item Turns Tear Rate Into DAMAGE | 355 | | The Binding of Isaac: Rebirth
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| 377. | First Person Isaac Is INSANELY FUN | 353 | | The Binding of Isaac: Rebirth
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| 378. | So I Found the Most INSANE Deal... | 353 | | The Binding of Isaac: Rebirth
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| 379. | I Got the GOLDEN Death Certificate!! | 353 | | The Binding of Isaac: Rebirth
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| 380. | The New Death Certificate Is Absolutely INSANE | 352 | | The Binding of Isaac: Rebirth
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| 381. | It's Not Over. | 352 | | The Binding of Isaac: Rebirth
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| 382. | This NEW Item Was My Biggest Mistake | 351 | | The Binding of Isaac: Rebirth
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| 383. | This Dice Gives The RAREST Items: | 350 | | The Binding of Isaac: Rebirth
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| 384. | The Most BROKEN Technology Item Ever: | 350 | Vlog | The Binding of Isaac: Rebirth
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| 385. | This New Character Is COMPLETELY Cursed | 350 | | The Binding of Isaac: Rebirth
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| 386. | The Rarest Character of ALL TIME | 349 | | The Binding of Isaac: Rebirth
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| 387. | Least insane modded item | 348 | | The Binding of Isaac: Rebirth
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| 388. | Playable Guppy Is FINALLY Here!! | 348 | | The Binding of Isaac: Rebirth
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| 389. | I Found The Most INSANE Devil Item In Isaac | 348 | | The Binding of Isaac: Rebirth
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| 390. | This NEW Item Gives INSANE Damage | 347 | | The Binding of Isaac: Rebirth
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| 391. | They Added A NEW Playable Boss, He's Amazing | 347 | | The Binding of Isaac: Rebirth
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| 392. | Least Rigged Mattman Run | 347 | | The Binding of Isaac: Rebirth
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| 393. | The Character That LITERALLY Breaks Everything: | 347 | | The Binding of Isaac: Rebirth
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| 394. | The GREATEST Isaac Tournament EVER | 347 | | The Binding of Isaac: Rebirth
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| 395. | New Character Synergies Just Dropped | 347 | | The Binding of Isaac: Rebirth
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| 396. | I Got The BEST Eden Start. It was a mistake. | 346 | | The Binding of Isaac: Rebirth
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| 397. | The Most SATISFYING Start Of All Time | 346 | | The Binding of Isaac: Rebirth
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| 398. | I Tried Isaac's HARDEST Challenge | 346 | | The Binding of Isaac: Rebirth
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| 399. | This New Bethany Is SO SATISFYING | 346 | | The Binding of Isaac: Rebirth
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| 400. | The Most Satisfying Luck EVER | 346 | | The Binding of Isaac: Rebirth
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