| 401. | The New Mom's Knife Synergies Are INSANE | 345 | | The Binding of Isaac: Rebirth
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| 402. | This NEW Dice Gives You Every Item Possible: | 345 | | The Binding of Isaac: Rebirth
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| 403. | I Achieved the Cricket's Head SPEEDRUN World Record | 345 | | The Binding of Isaac: Rebirth
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| 404. | The Greatest Addition to Isaac EVER | 344 | | The Binding of Isaac: Rebirth
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| 405. | This New Character Is INSANELY Challenging... | 343 | | The Binding of Isaac: Rebirth
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| 406. | They Added A New Evil Character. She's INSANE. | 343 | | The Binding of Isaac: Rebirth
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| 407. | Vitiated Forgotten Is INSANELY Challenging | 342 | | The Binding of Isaac: Rebirth
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| 408. | I Got The RAREST Sacred Heart EVER | 342 | | The Binding of Isaac: Rebirth
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| 409. | How I Unlocked Mega Blast | 341 | | The Binding of Isaac: Rebirth
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| 410. | I Committed TAX EVASION in Repentance | 341 | | The Binding of Isaac: Rebirth
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| 411. | The New Isaac Update Is INSANE (Repentance v1.9.2) | 341 | Vlog | The Binding of Isaac: Rebirth
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| 412. | This Floor Gave Me EVERY Quality 4 Item | 341 | | The Binding of Isaac: Rebirth
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| 413. | Why I ALWAYS Check My Secret Room | 341 | | The Binding of Isaac: Rebirth
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| 414. | I Found The RAREST Room In Isaac | 340 | | The Binding of Isaac: Rebirth
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| 415. | This New Item Gave Me CRAZY Damage | 338 | | The Binding of Isaac: Rebirth
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| 416. | This New Item is BROKEN (literally) | 338 | | The Binding of Isaac: Rebirth
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| 417. | WE'RE SO BACK | 337 | | The Binding of Isaac: Rebirth
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| 418. | They Added A LASER SWORD!! | 337 | | The Binding of Isaac: Rebirth
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| 419. | So I Ranked Isaac Items... | 337 | | The Binding of Isaac: Rebirth
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| 420. | This New Character Is RIDICULOUS | 336 | | The Binding of Isaac: Rebirth
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| 421. | These New Items Are CRAZY | 335 | | The Binding of Isaac: Rebirth
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| 422. | The New Milk Item Gives You UNLIMITED Tears (kinda) | 335 | | The Binding of Isaac: Rebirth
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| 423. | How I Unlocked Godhead | 335 | | The Binding of Isaac: Rebirth
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| 424. | Average Eden Start: | 335 | | The Binding of Isaac: Rebirth
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| 425. | These New Items Are INSANE | 333 | | The Binding of Isaac: Rebirth
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| 426. | I Achieved the Sacred Orb SPEEDRUN World Record | 333 | | The Binding of Isaac: Rebirth
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| 427. | I'll Literally Never Get This Lucky Again | 332 | | The Binding of Isaac: Rebirth
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| 428. | I Cheated With YOUR Help In Isaac | 332 | | The Binding of Isaac: Rebirth
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| 429. | Literally Every Mattman Run: | 332 | | The Binding of Isaac: Rebirth
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| 430. | The Character That Can Do (Literally) Everything | 332 | | The Binding of Isaac: Rebirth
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| 431. | I Played the Most PUNISHING Character Ever | 332 | | The Binding of Isaac: Rebirth
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| 432. | This New Character Is ACTUALLY Insane | 332 | | The Binding of Isaac: Rebirth
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| 433. | They Added Death Certificate 2 and its HILARIOUS | 330 | | The Binding of Isaac: Rebirth
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| 434. | What Getting Every Quality 4 Item Looks Like | 330 | | The Binding of Isaac: Rebirth
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| 435. | How I Got the LUCKIEST First Floor | 330 | | The Binding of Isaac: Rebirth
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| 436. | This NEW Sword Item Is Simply Amazing | 329 | | The Binding of Isaac: Rebirth
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| 437. | Tainted Mattman Is Good and Real | 329 | | The Binding of Isaac: Rebirth
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| 438. | How I Unlocked Tarnished Samson | 329 | | The Binding of Isaac: Rebirth
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| 439. | I let my chat gaslight me. It was a mistake. | 328 | | The Binding of Isaac: Rebirth
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| 440. | How I Got HAEMOLACRIA in 1.97 Seconds | 328 | | The Binding of Isaac: Rebirth
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| 441. | I Beat Isaac's IMPOSSIBLE Challenge (Dads Home+) | 328 | | The Binding of Isaac: Rebirth
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| 442. | I Found the INFINITE Lives Glitch | 328 | | The Binding of Isaac: Rebirth
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| 443. | My LUCKIEST Start Ever | 327 | | The Binding of Isaac: Rebirth
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| 444. | Playable Host Is Absolutely INSANE (ASMR) | 327 | | The Binding of Isaac: Rebirth
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| 445. | The New Tech Item Gives UNLIMITED Lasers | 325 | | The Binding of Isaac: Rebirth
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| 446. | This NEW Quality 4 Made Me Cry... | 325 | | The Binding of Isaac: Rebirth
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| 447. | I Played As Delirium. It's CRAZY. | 325 | | The Binding of Isaac: Rebirth
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| 448. | The Fastest Dice of ALL TIME | 325 | | The Binding of Isaac: Rebirth
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| 449. | Brimstone but 1000x worse | 325 | | The Binding of Isaac: Rebirth
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| 450. | The Dice That MULTIPLIES Items | 323 | | The Binding of Isaac: Rebirth
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| 451. | This New Dice Was A Mistake | 323 | | The Binding of Isaac: Rebirth
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| 452. | BIGGEST Mistake In Isaac History: | 323 | | The Binding of Isaac: Rebirth
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| 453. | I Played With These Isaac Youtubers. it was a mistake. | 323 | | The Binding of Isaac: Rebirth
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| 454. | I Unlocked GOLDEN Items. It was a mistake. | 323 | | The Binding of Isaac: Rebirth
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| 455. | I've NEVER Made A Bigger Mistake... | 322 | | The Binding of Isaac: Rebirth
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| 456. | The Luckiest Eden Run Of All Time? | 322 | | The Binding of Isaac: Rebirth
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| 457. | New Most Difficult Character Just Dropped | 321 | | The Binding of Isaac: Rebirth
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| 458. | This New Item Upgrades EVERYTHING To Quality 4: | 321 | | The Binding of Isaac: Rebirth
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| 459. | Repentance's NEW Best Item in the Game: | 320 | | The Binding of Isaac: Rebirth
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| 460. | Luckiest Floor EVER | 320 | | The Binding of Isaac: Rebirth
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| 461. | This Was A TERRIBLE Mistake | 320 | | The Binding of Isaac: Rebirth
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| 462. | I Beat 60+ BOSSES with NO ITEMS in The Binding of Isaac: Repentance | 320 | | The Binding of Isaac: Rebirth
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| 463. | How I Unlocked Tarnished Cain | 320 | | The Binding of Isaac: Rebirth
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| 464. | This Mod Is Illegal | 319 | | The Binding of Isaac: Rebirth
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| 465. | I Discovered the RAREST Room In Repentance | 319 | | The Binding of Isaac: Rebirth
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| 466. | This NEW Milk Item Tastes Incredible | 319 | | The Binding of Isaac: Rebirth
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| 467. | They Made Jacob And Esau Even HARDER | 318 | | The Binding of Isaac: Rebirth
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| 468. | This First Floor is PERFECT | 318 | | The Binding of Isaac: Rebirth
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| 469. | They Added RAINBOW Brimstone From Undertale... | 317 | | Undertale
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| 470. | How I Unlocked Tainted Jacob | 317 | | The Binding of Isaac: Rebirth
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| 471. | This New Item Gives INFINITE Familiars. It's Insane. | 317 | | The Binding of Isaac: Rebirth
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| 472. | The EASIEST Stats I've Ever Farmed | 316 | | The Binding of Isaac: Rebirth
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| 473. | Why I ALWAYS Take Sacred Orb | 316 | | The Binding of Isaac: Rebirth
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| 474. | The Character That Has SECRET Planetariums: | 316 | | The Binding of Isaac: Rebirth
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| 475. | Epic Fetus FINALLY Has Synergies | 315 | | The Binding of Isaac: Rebirth
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| 476. | When Your FIRST Item Is Glitched Crown: | 315 | | The Binding of Isaac: Rebirth
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| 477. | If I Stop Moving, My Stats Disappear | 313 | | The Binding of Isaac: Rebirth
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| 478. | Playable Siren Is INCREDIBLE | 313 | | The Binding of Isaac: Rebirth
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| 479. | These NEW Dice Are Completely Broken | 312 | | The Binding of Isaac: Rebirth
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| 480. | How I Got MAGIC MUSHROOM in 1.52 Seconds | 312 | | The Binding of Isaac: Rebirth
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| 481. | I Rigged The PERFECT Speedrun: | 312 | | The Binding of Isaac: Rebirth
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| 482. | I Found the PERFECT Eden Start | 311 | | The Binding of Isaac: Rebirth
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| 483. | Unlocking Tarnished Keeper | 311 | | The Binding of Isaac: Rebirth
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| 484. | The WORST Start In Isaac History... | 310 | | The Binding of Isaac: Rebirth
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| 485. | Craziest First Floor | 310 | | The Binding of Isaac: Rebirth
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| 486. | Rock Bottom Moment | 309 | | The Binding of Isaac: Rebirth
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| 487. | The Modded Isaac Experience | 309 | | The Binding of Isaac: Rebirth
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| 488. | The Run Was Rigged From The Start | 308 | | The Binding of Isaac: Rebirth
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| 489. | The NEW Character Is Incredibly Stupid | 308 | | The Binding of Isaac: Rebirth
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| 490. | Damocles Moment | 308 | | The Binding of Isaac: Rebirth
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| 491. | This NEW Dice Broke My Game | 307 | | The Binding of Isaac: Rebirth
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| 492. | They Added THIS to Repentance?? | 307 | | The Binding of Isaac: Rebirth
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| 493. | One Reroll, EVERY Quality 4 Item. | 307 | | The Binding of Isaac: Rebirth
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| 494. | The Most SATISFYING Character Ever: | 306 | | The Binding of Isaac: Rebirth
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| 495. | How I Unlocked Tainted Judas | 306 | | The Binding of Isaac: Rebirth
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| 496. | This Character Has INFINITE Lives | 306 | | The Binding of Isaac: Rebirth
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| 497. | This Is What 1,000,000+ Bombs Per Second Looks Like | 305 | | The Binding of Isaac: Rebirth
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| 498. | Restarting Gave Me THIS | 305 | | The Binding of Isaac: Rebirth
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| 499. | Golden Horse Pill = Infinite Stats | 305 | | The Binding of Isaac: Rebirth
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| 500. | This NEW Shovel Can Dig Up Quality 4's: | 305 | | The Binding of Isaac: Rebirth
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