| 201. | The Time I "Beta Tested" the New Isaac Update | 5,713 | | The Binding of Isaac: Rebirth
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| 202. | The HARDEST Character I've Ever Played: | 6,425 | | The Binding of Isaac: Rebirth
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| 203. | The Luckiest Eden Run Of All Time? | 6,574 | | The Binding of Isaac: Rebirth
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| 204. | Most Satisfying Deal | 5,692 | | The Binding of Isaac: Rebirth
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| 205. | I Found the LUCKIEST Start In Isaac History | 6,457 | | The Binding of Isaac: Rebirth
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| 206. | How I Beat Delirium Without Moving | 6,734 | | The Binding of Isaac: Rebirth
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| 207. | The New Character Is INSANELY FUN | 5,659 | | The Binding of Isaac: Rebirth
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| 208. | How I Got the LUCKIEST First Floor | 5,652 | | The Binding of Isaac: Rebirth
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| 209. | The TM Trainer Incident | 5,635 | | The Binding of Isaac: Rebirth
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| 210. | How I Got HAEMOLACRIA in 1.97 Seconds | 5,933 | | The Binding of Isaac: Rebirth
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| 211. | What If The Gideon Fight Was INFINITE? | 5,668 | | The Binding of Isaac: Rebirth
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| 212. | What Happens If Isaac Gets INFINITE Quad Shots? | 5,604 | | The Binding of Isaac: Rebirth
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| 213. | Most Chaotic Character EVER | 5,887 | | The Binding of Isaac: Rebirth
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| 214. | Isaac Got Flashified 💀 | 5,664 | | The Binding of Isaac: Rebirth
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| 215. | This NEW Death Certificate Is Crazy | 6,207 | | The Binding of Isaac: Rebirth
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| 216. | How I Unlocked Tainted Jacob | 5,589 | | The Binding of Isaac: Rebirth
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| 217. | I Achieved the Sacred Orb SPEEDRUN World Record | 5,567 | | The Binding of Isaac: Rebirth
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| 218. | Dr. Fetus Just Got A MAJOR Upgrade | 7,265 | | The Binding of Isaac: Rebirth
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| 219. | This Is The End. | 5,556 | | The Binding of Isaac: Rebirth
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| 220. | First Person Isaac Is INSANELY FUN | 5,552 | | The Binding of Isaac: Rebirth
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| 221. | New Most Difficult Character Just Dropped | 6,105 | | The Binding of Isaac: Rebirth
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| 222. | Epic Fetus FINALLY Has Synergies | 5,543 | | The Binding of Isaac: Rebirth
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| 223. | 1000+ DMG PER SECOND | 5,542 | | The Binding of Isaac: Rebirth
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| 224. | They Added A LASER SWORD!! | 5,531 | | The Binding of Isaac: Rebirth
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| 225. | These New Hearts Give You INFINITE Stats | 5,927 | | The Binding of Isaac: Rebirth
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| 226. | THEY SHRUNK HIM | 5,529 | | The Binding of Isaac: Rebirth
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| 227. | This Dice COMPLETELY Breaks The Game: | 5,529 | | The Binding of Isaac: Rebirth
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| 228. | Vitiated Forgotten Is INSANELY Challenging | 5,529 | | The Binding of Isaac: Rebirth
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| 229. | What 3000 Hours of Isaac Looks Like... | 6,686 | | The Binding of Isaac: Rebirth
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| 230. | How I Unlocked Godhead | 5,522 | | The Binding of Isaac: Rebirth
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| 231. | The PERFECT Shop Start... | 5,517 | | The Binding of Isaac: Rebirth
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| 232. | This Character Has COMPLETELY New Synergies | 5,515 | | The Binding of Isaac: Rebirth
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| 233. | This Character Has A BRIMSTONE Gun | 6,470 | | The Binding of Isaac: Rebirth
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| 234. | The New R Key Is ACTUALLY Broken | 5,805 | | The Binding of Isaac: Rebirth
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| 235. | How I Unlocked Tainted Lost | 5,482 | | The Binding of Isaac: Rebirth
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| 236. | How I Unlocked Rock Bottom | 5,479 | | The Binding of Isaac: Rebirth
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| 237. | They Made Isaac Items 3D!! | 6,010 | | The Binding of Isaac: Rebirth
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| 238. | Least Rigged Mattman Run | 5,471 | | The Binding of Isaac: Rebirth
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| 239. | These New Items Are SO SATISFYING | 5,470 | | The Binding of Isaac: Rebirth
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| 240. | I Played The Most BASED Repentance Character | 5,464 | | The Binding of Isaac: Rebirth
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| 241. | Luckiest Floor EVER | 5,458 | | The Binding of Isaac: Rebirth
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| 242. | Why I ALWAYS Take Sacred Orb | 5,445 | | The Binding of Isaac: Rebirth
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| 243. | The Most INSANE Synergy In the Game: | 5,441 | | The Binding of Isaac: Rebirth
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| 244. | How I Got C SECTION In 1.49 Seconds | 5,435 | | The Binding of Isaac: Rebirth
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| 245. | I Tried This SECRET Challenge Character | 5,432 | | The Binding of Isaac: Rebirth
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| 246. | These New Final Bosses Are WILD | 6,493 | | The Binding of Isaac: Rebirth
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| 247. | Disappointing Update News | 5,400 | | The Binding of Isaac: Rebirth
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| 248. | Tainted Mastema Is AMAZING | 5,400 | | The Binding of Isaac: Rebirth
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| 249. | The NEW Character That Crashed My Game | 5,919 | | The Binding of Isaac: Rebirth
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| 250. | Mentally Unhinged Isaac (Ft. NotAlbino) | 9,100 | | The Binding of Isaac: Rebirth
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| 251. | This Was A TERRIBLE Mistake | 5,377 | | The Binding of Isaac: Rebirth
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| 252. | This Mod Changes EVERYTHING!! | 5,550 | | The Binding of Isaac: Rebirth
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| 253. | The NEW Apollyon Rework is Incredible | 5,369 | | The Binding of Isaac: Rebirth
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| 254. | The NEW Guppy Item Is Perfect | 5,597 | | The Binding of Isaac: Rebirth
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| 255. | This New Dice Has INFINITE Possibilities | 5,346 | | The Binding of Isaac: Rebirth
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| 256. | The Most SATISFYING Character Ever: | 5,344 | | The Binding of Isaac: Rebirth
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| 257. | This Infinite Tear Item Is HILARIOUS | 5,963 | | The Binding of Isaac: Rebirth
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| 258. | They Turned Blue Baby Into Red Baby 💀💀 | 5,312 | | The Binding of Isaac: Rebirth
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| 259. | This RARE New Room Gives the BEST Items | 6,032 | | The Binding of Isaac: Rebirth
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| 260. | They Added A NEW Playable Boss, He's Amazing | 5,303 | | The Binding of Isaac: Rebirth
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| 261. | I Found the PERFECT Eden Start | 5,297 | | The Binding of Isaac: Rebirth
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| 262. | This New Item Gives You INFINITE Tears | 5,826 | | The Binding of Isaac: Rebirth
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| 263. | Golden Diplopia Is INSANE | 5,290 | | The Binding of Isaac: Rebirth
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| 264. | Isaac Online Is Crazy | 5,731 | | The Binding of Isaac: Rebirth
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| 265. | I'll Literally Never Get This Lucky Again | 5,288 | | The Binding of Isaac: Rebirth
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| 266. | The New Death Certificate Is Absolutely INSANE | 5,624 | | The Binding of Isaac: Rebirth
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| 267. | This Dice Gives The RAREST Items: | 5,282 | | The Binding of Isaac: Rebirth
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| 268. | Least Powerful Modded Character | 6,147 | | The Binding of Isaac: Rebirth
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| 269. | Incredibly Satisfying Shot | 5,275 | | The Binding of Isaac: Rebirth
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| 270. | Playable Siren Is INCREDIBLE | 5,272 | | The Binding of Isaac: Rebirth
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| 271. | I Gulped EVERY Trinket in Isaac. It was a mistake. | 5,271 | Let's Play | The Binding of Isaac: Rebirth
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| 272. | This New Modded Character Is SO SATISFYING | 5,605 | | The Binding of Isaac: Rebirth
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| 273. | This Character Has The MAXIMUM Damage Multiplier: | 6,021 | | The Binding of Isaac: Rebirth
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| 274. | This NEW Item Is So Satisfying | 5,782 | | The Binding of Isaac: Rebirth
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| 275. | They Added a NEW Angel Fight. It's insane. | 5,683 | | The Binding of Isaac: Rebirth
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| 276. | How I Unlocked the Forgotten | 5,235 | | The Binding of Isaac: Rebirth
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| 277. | This Modded Void Rework Is Absolutely AMAZING | 5,235 | | The Binding of Isaac: Rebirth
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| 278. | This New Tech Dice Is LITERALLY Cheating | 6,204 | | The Binding of Isaac: Rebirth
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| 279. | What Infinite Stats ACTUALLY Looks Like: | 5,409 | | The Binding of Isaac: Rebirth
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| 280. | Spindown Dice is S-Tier | 5,226 | | The Binding of Isaac: Rebirth
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| 281. | World's Smallest Isaac Character | 5,223 | | The Binding of Isaac: Rebirth
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| 282. | The Character That Has INFINITE Items: | 5,222 | | The Binding of Isaac: Rebirth
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| 283. | I Achieved 1 in 1,000,000 Luck | 6,636 | | The Binding of Isaac: Rebirth
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| 284. | This NEW Item Gave Me Unlimited Tears | 5,899 | | The Binding of Isaac: Rebirth
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| 285. | This NEW Shovel Can Dig Up Quality 4's: | 6,126 | | The Binding of Isaac: Rebirth
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| 286. | This NEW Character Is Adorable | 5,917 | | The Binding of Isaac: Rebirth
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| 287. | This Synergy Is EASILY the Most Satisfying | 5,211 | | The Binding of Isaac: Rebirth
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| 288. | How ONE Button Press INSTANTLY Broke My Game: | 5,195 | | The Binding of Isaac: Rebirth
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| 289. | The Most SATISFYING Start In Isaac History? | 7,115 | | The Binding of Isaac: Rebirth
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| 290. | Isaac Rigged Moment | 5,193 | | The Binding of Isaac: Rebirth
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| 291. | This New Modded Item Is RIDICULOUS | 5,190 | | The Binding of Isaac: Rebirth
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| 292. | This Isaac Challenge Made Me Cry | 5,189 | | The Binding of Isaac: Rebirth
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| 293. | These NEW Synergies Are INSANELY FUN... | 5,564 | | The Binding of Isaac: Rebirth
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| 294. | The CHEAPEST Free Win I've Ever Seen | 5,167 | | The Binding of Isaac: Rebirth
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| 295. | The Most Satisfying Eden Start: | 5,164 | | The Binding of Isaac: Rebirth
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| 296. | The New Isaac Update Is INSANE (Repentance v1.9.2) | 5,732 | Vlog | The Binding of Isaac: Rebirth
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| 297. | I Found The CRAZIEST Angel Item In Isaac | 5,492 | | The Binding of Isaac: Rebirth
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| 298. | Tainted Forgotten.exe | 5,154 | | The Binding of Isaac: Rebirth
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| 299. | MEGA SWORD | 5,148 | | The Binding of Isaac: Rebirth
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| 300. | Isaac's NEW Difficulty Is Completely: | 5,831 | | The Binding of Isaac: Rebirth
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