| 401. | Least Powerful Modded Character | 160,515 | | The Binding of Isaac: Rebirth
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| 402. | The Legend Of Strawman | 160,487 | | The Binding of Isaac: Rebirth
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| 403. | The New Ghost Pepper Rework Is INSANE | 160,463 | | The Binding of Isaac: Rebirth
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| 404. | What INFINITE Luck Looks Like | 160,408 | | The Binding of Isaac: Rebirth
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| 405. | This New Final Boss And Ending Were Simply Amazing | 160,225 | | The Binding of Isaac: Rebirth
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| 406. | Tainted Delirium Is INSANELY Difficult | 160,158 | | The Binding of Isaac: Rebirth
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| 407. | This First Floor Was SO Satisfying | 159,763 | | The Binding of Isaac: Rebirth
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| 408. | LUCKIEST Secret Room Possible | 159,748 | | The Binding of Isaac: Rebirth
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| 409. | How I Unlocked Birthright | 159,706 | | The Binding of Isaac: Rebirth
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| 410. | Disappointing Update News | 159,567 | | The Binding of Isaac: Rebirth
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| 411. | I Found The Most SATISFYING Synergy | 159,474 | | The Binding of Isaac: Rebirth
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| 412. | Isaac Modding Has Changed FOREVER!! | 159,385 | | The Binding of Isaac: Rebirth
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| 413. | This Start Was A Mistake | 159,142 | | The Binding of Isaac: Rebirth
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| 414. | How I Dominated Delirium with Tainted Lost in Repentance | 159,089 | | The Binding of Isaac: Rebirth
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| 415. | The Most SATISFYING Tarnished Keeper | 158,975 | | The Binding of Isaac: Rebirth
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| 416. | This First Floor Had The CRAZIEST Luck: | 158,896 | | The Binding of Isaac: Rebirth
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| 417. | The NEW Character Is Cursed | 158,684 | | The Binding of Isaac: Rebirth
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| 418. | This is What DEAD GOD Luck Looks Like: | 158,423 | | The Binding of Isaac: Rebirth
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| 419. | The GREATEST Isaac Tournament EVER | 158,404 | | The Binding of Isaac: Rebirth
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| 420. | This Shop has the BEST Items: | 158,359 | | The Binding of Isaac: Rebirth
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| 421. | This is PERFECTION | 158,040 | | The Binding of Isaac: Rebirth
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| 422. | This New Dice Has INFINITE Possibilities | 157,799 | | The Binding of Isaac: Rebirth
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| 423. | The New Isaac Update is HUGE (Repentance v.1.9.7) | 157,782 | Vlog | The Binding of Isaac: Rebirth
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| 424. | I Found The RAREST Room In Isaac | 157,665 | | The Binding of Isaac: Rebirth
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| 425. | Huge Isaac Update | 157,245 | Vlog | The Binding of Isaac: Rebirth
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| 426. | I Achieved the Cricket's Head SPEEDRUN World Record | 157,223 | | The Binding of Isaac: Rebirth
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| 427. | I Gave Isaac 64 Death Certificates. This Was The Result | 157,181 | | The Binding of Isaac: Rebirth
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| 428. | When I accidentally get too lucky | 157,164 | | The Binding of Isaac: Rebirth
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| 429. | I Will NEVER Have This Luck Again | 157,154 | | The Binding of Isaac: Rebirth
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| 430. | This New Character BREAKS Time and Space: | 157,123 | | The Binding of Isaac: Rebirth
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| 431. | I Gulped EVERY Trinket in Isaac. It was a mistake. | 156,667 | Let's Play | The Binding of Isaac: Rebirth
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| 432. | Isaac's NEW Difficulty Is Completely: | 156,355 | | The Binding of Isaac: Rebirth
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| 433. | Most Satisfying Luck | 156,322 | | The Binding of Isaac: Rebirth
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| 434. | Craziest First Floor | 156,273 | | The Binding of Isaac: Rebirth
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| 435. | The New Tech Item Is INSANE | 156,224 | | The Binding of Isaac: Rebirth
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| 436. | These New Hearts Give You INFINITE Stats | 156,182 | | The Binding of Isaac: Rebirth
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| 437. | They Added A NEW Playable Boss, He's Amazing | 156,111 | | The Binding of Isaac: Rebirth
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| 438. | Tainted Keeper Be LIke: | 156,069 | | The Binding of Isaac: Rebirth
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| 439. | This Dice Gives The RAREST Items: | 156,018 | | The Binding of Isaac: Rebirth
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| 440. | The Most SATISFYING Start Of All Time | 155,918 | | The Binding of Isaac: Rebirth
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| 441. | The Most SATISFYING Synergy I've Ever Found | 155,858 | | The Binding of Isaac: Rebirth
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| 442. | How I Beat Delirium Without Moving | 155,768 | | The Binding of Isaac: Rebirth
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| 443. | I Time Traveled Through 10 Timelines to Get This Brimstone | 155,508 | | The Binding of Isaac: Rebirth
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| 444. | I Beat The Unbeatable Eden Seed | 155,463 | | The Binding of Isaac: Rebirth
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| 445. | I Abused INFINITE Rerolls | 155,387 | | The Binding of Isaac: Rebirth
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| 446. | These NEW Apollyon Buffs Are Crazy | 155,271 | | The Binding of Isaac: Rebirth
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| 447. | The 1 In 1,000,000 Synergy | 155,237 | | The Binding of Isaac: Rebirth
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| 448. | 1000+ TEARS PER SECOND | 155,212 | | The Binding of Isaac: Rebirth
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| 449. | We Tried Adding RTX Technology To Isaac | 155,114 | | The Binding of Isaac: Rebirth
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| 450. | This Is WAY Too Satisfying | 154,499 | | The Binding of Isaac: Rebirth
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| 451. | Incredibly Satisfying Shot | 154,243 | | The Binding of Isaac: Rebirth
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| 452. | THE 10,000+ DAMAGE SHOT | 154,218 | | The Binding of Isaac: Rebirth
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| 453. | New Most Difficult Character Just Dropped | 153,940 | | The Binding of Isaac: Rebirth
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| 454. | This New Item Gives You INFINITE Tears | 153,933 | | The Binding of Isaac: Rebirth
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| 455. | The New R Key Is ACTUALLY Broken | 153,768 | | The Binding of Isaac: Rebirth
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| 456. | The Sword That INSTANTLY Broke My Game | 153,695 | | The Binding of Isaac: Rebirth
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| 457. | Most BASED Lilith Run: | 153,665 | | The Binding of Isaac: Rebirth
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| 458. | We Added Rock Bottom 2. It's INSANE. | 153,467 | | The Binding of Isaac: Rebirth
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| 459. | I Achieved the Death Certificate SPEEDRUN World Record | 153,459 | | The Binding of Isaac: Rebirth
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| 460. | How I BOUGHT Infinite TEARS | 153,361 | | The Binding of Isaac: Rebirth
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| 461. | When You Have DEAD GOD You Get Runs Like These | 153,188 | | The Binding of Isaac: Rebirth
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| 462. | 0% Skill, 100% Luck | 153,107 | | The Binding of Isaac: Rebirth
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| 463. | how it feels to play tainted lost in Repentance | 153,025 | | The Binding of Isaac: Rebirth
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| 464. | Most Fragile Character EVER | 152,885 | | The Binding of Isaac: Rebirth
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| 465. | Tainted Lost Gets "Better" Items | 152,282 | | The Binding of Isaac: Rebirth
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| 466. | I Committed TAX EVASION in Repentance | 152,082 | | The Binding of Isaac: Rebirth
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| 467. | This Is TOO Satisfying | 151,941 | | The Binding of Isaac: Rebirth
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| 468. | Buffed Tainted Apollyon Is INSANE (Repentance+ DLC) | 151,925 | | The Binding of Isaac: Rebirth
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| 469. | The LUCKIEST Eden Start Of The Year? | 151,912 | | The Binding of Isaac: Rebirth
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| 470. | How I Broke My Game with ONE Bomb: | 151,767 | | The Binding of Isaac: Rebirth
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| 471. | The New Isaac Update Is INSANE (Repentance v1.9.2) | 151,656 | Vlog | The Binding of Isaac: Rebirth
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| 472. | This Was A TERRIBLE Mistake | 151,578 | | The Binding of Isaac: Rebirth
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| 473. | I Beat 60+ BOSSES with NO ITEMS in The Binding of Isaac: Repentance | 151,025 | | The Binding of Isaac: Rebirth
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| 474. | They Added MINECRAFT To Isaac!! | 150,878 | | The Binding of Isaac: Rebirth
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| 475. | I Got The C Section SPEEDRUN World Record | 150,821 | | The Binding of Isaac: Rebirth
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| 476. | Vitiated Forgotten Is INSANELY Challenging | 150,571 | | The Binding of Isaac: Rebirth
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| 477. | The New Dice Makes No Sense | 150,472 | | The Binding of Isaac: Rebirth
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| 478. | They Finally Added STRAWBERRY Milk | 150,404 | | The Binding of Isaac: Rebirth
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| 479. | They Added Birthwrong. It's Crazy... | 150,086 | | The Binding of Isaac: Rebirth
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| 480. | This Character Has A BRIMSTONE Gun | 149,905 | | The Binding of Isaac: Rebirth
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| 481. | This Mod Changes Literally EVERYTHING | 149,887 | | The Binding of Isaac: Rebirth
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| 482. | Playing As Dogma is Simply Amazing | 149,607 | | The Binding of Isaac: Rebirth
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| 483. | This New Character Has INSANE Synergies | 149,536 | | The Binding of Isaac: Rebirth
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| 484. | These New Items Are SO SATISFYING | 149,393 | | The Binding of Isaac: Rebirth
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| 485. | This NEW Item Gives INSANE Damage | 149,354 | | The Binding of Isaac: Rebirth
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| 486. | Playable Dio Is ACTUALLY Amazing | 149,309 | | The Binding of Isaac: Rebirth
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| 487. | I Tried This SECRET Challenge Character | 149,000 | | The Binding of Isaac: Rebirth
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| 488. | The Most Satisfying Luck EVER | 148,947 | | The Binding of Isaac: Rebirth
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| 489. | GODLY Rerolls | 148,913 | | The Binding of Isaac: Rebirth
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| 490. | The Character That Has INFINITE Items: | 148,689 | | The Binding of Isaac: Rebirth
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| 491. | Mattman Dice Is Fair and Balanced | 148,683 | | The Binding of Isaac: Rebirth
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| 492. | They Turned This Boss Into My Worst Nightmare | 148,612 | | The Binding of Isaac: Rebirth
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| 493. | What 4000 Hours in Isaac Looks Like: | 148,535 | | The Binding of Isaac: Rebirth
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| 494. | This New Dice Is INSANE | 148,445 | | The Binding of Isaac: Rebirth
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| 495. | Rock Bottom But It's Entirely Useless | 148,409 | | The Binding of Isaac: Rebirth
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| 496. | I Found the NEW Evil Sacred Heart. It's Amazing. | 148,156 | | The Binding of Isaac: Rebirth
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| 497. | Incredibly Satisfying Luck | 148,028 | | The Binding of Isaac: Rebirth
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| 498. | Isaac, But I Have a FaceCam | 148,027 | | The Binding of Isaac: Rebirth
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| 499. | We Tried Adding Mutant Spider 2. Big Mistake. | 147,884 | | The Binding of Isaac: Rebirth
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| 500. | This New Mod Is TERRIFYING | 147,810 | | The Binding of Isaac: Rebirth
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