| 401. | Official TBOI Item Guides No. 248: Hive Mind | 1,244 | | Hive Mind
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| 402. | Official TBOI Item Guides No. 217: Mom's Wig | 1,220 | | The Binding of Isaac: Rebirth
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| 403. | Official TBOI Item Guides No. 255: Screw | 1,215 | | The Binding of Isaac: Rebirth
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| 404. | Official TBOI Item Guides No. 252: Little Baggy | 1,213 | | The Binding of Isaac: Rebirth
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| 405. | Official TBOI Item Guides No. 251: Starter Deck | 1,212 | | The Binding of Isaac: Rebirth
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| 406. | Official TBOI Item Guides No. 228: Mom's Perfume | 1,205 | | The Binding of Isaac: Rebirth
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| 407. | Official TBOI Item Guides No. 214: Anemic | 1,205 | | The Binding of Isaac: Rebirth
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| 408. | Official TBOI Item Guides No. 231: Ball of Tar | 1,202 | | The Binding of Isaac: Rebirth
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| 409. | Official TBOI Item Guides No. 191: 3 Dollar Bill | 1,187 | | The Binding of Isaac: Rebirth
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| 410. | Official TBOI Item Guides No. 270: Leech | 1,182 | | The Binding of Isaac: Rebirth
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| 411. | Official TBOI Item Guides No. 243: Trinity Shield | 1,170 | | The Binding of Isaac: Rebirth
|
| 412. | HyperParasite Nintendo Switch Physical Edition Announcement Trailer (Updated) | 1,129 | | HyperParasite
|
| 413. | Official TBOI Item Guides No. 260: Black Candle | 1,128 | | The Binding of Isaac
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| 414. | Official TBOI Item Guides No. 264: Smart Fly | 1,115 | | The Binding of Isaac: Rebirth
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| 415. | Official TBOI Item Guides No. 246: Blue Map | 1,089 | | The Binding of Isaac: Rebirth
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| 416. | Official TBOI Item Guides No. 250: BOGO Bombs | 1,083 | | The Binding of Isaac: Rebirth
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| 417. | Official TBOI Item Guides No. 262: Missing Page 2 | 1,030 | | The Binding of Isaac: Rebirth
|
| 418. | Official TBOI Item Guides No. 267: Robo Baby 2.0 | 994 | |
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| 419. | Official TBOI Item Guides No. 269: Headless Baby | 990 | | The Binding of Isaac: Rebirth
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| 420. | Official TBOI Item Guides No. 256: Hot Bombs | 972 | | The Binding of Isaac: Rebirth
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| 421. | Wanna Survive Launch Trailer | 965 | | Wanna Survive
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| 422. | Official TBOI Item Guides No. 275: Lil Brimstone | 948 | | The Binding of Isaac: Rebirth
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| 423. | Official TBOI Item Guides No. 274: Best Bud | 944 | | The Binding of Isaac: Rebirth
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| 424. | Official TBOI Item Guides No. 254: Blood Clot | 934 | | The Binding of Isaac
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| 425. | Dimensional Intersection Launch Trailer | 915 | |
|
| 426. | Dimensional Intersection Release Date Trailer | 854 | |
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| 427. | NecroLand: Undead Corps Release Date Announcement! | 772 | | NecroLand : Undead Corps
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| 428. | Official TBOI Item Guides No. 276: Isaac's Heart | 759 | |
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| 429. | HyperParasite Nintendo Switch Physical Edition with 3D Card | 712 | | HyperParasite
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| 430. | Nicalis Summer Sale at the Epic Games Store | 645 | |
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| 431. | Air Missions: HIND Launch Trailer | 568 | | Air Missions: HIND
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| 432. | Cats Away Launch Trailer (Nintendo Switch, PS5, Steam) | 533 | | Cave Story
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| 433. | Nicalis Halloween 2022 Sale at the Epic Games Store | 498 | |
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