| 1. |  GameHunter20xx | 408 | ANNO Mutationem - Playthrough #21 - Final Boss and Bad & Good Endings!!! (4K 60 FPS) | 48:54 |
| 2. | AUDREY GAMES | 322 | fighting strange beasts | ANNO: Mutationem [5] | 1:27:19 |
| 3. | MandyleePlays | 224 | Mandyleeplays ANNO: Mutationem - Indie Game Spotlight (switch edition) | 1:56:23 |
| 4. | Anoobis Gaming | 111 | Anoobis Plays! ANNO: Mutationem! [Episode 14: Feelings Run Amok (END)] | 2:09:36 |
| 5. | BigFatBabyLegs | 106 | ( PS5 ) ANNO: Mutationem Gameplay Part 11 | 46:12 |
| 6. | CrimsonBlaze | 105 | Let's Play ANNO: Mutationem - Bad Ending | 7:27 |
| 7. | Alterego912 | 85 | AlterEgo Plays ANNO Mutationem Part 17 (Finale) | 1:38:09 |
| 8. | Elemental Pixel Vod | 58 | [Switch] | Part 4 | Lego Harry Potter Year 1-7 | Twitch Playthrough | Vod | 2:35:59 |
| 9. | AMultiverseAuthor | 36 | ANNO: Mutationem Playthrough - Part 3 | 31:44 |
| 10. | Eternal-CMO | 31 | ANNO: Mutationem Playthrough | Part 2 - Freeway 42 | 2:05:07 |
| 11. | Barri B. Nub Ch | 28 | [Let's Play] Anno Mutationum ep 5 | 35:04 |
| 12. | Digital Phantom | 24 | Anno Mutationem (Re-Playthrough) - Part 2 | 31:54 |
| 13. | Offbeat! | 19 | Cyberpunk May Cry - ANNO: Mutationem | 2:18:12 |
| 14. | JollyReaper | 18 | Anno: Mutationem Demo Playthrough | 32:23 |
| 15. | Moycor's Dreams | 18 | Anno: Mutationem (Playthrough No Commentary) Ep 2 | 1:14:03 |
| 16. | FlamingGnats | 17 | ANNO Mutationem Playthrough - Part 1 | 35:54 |
| 17. | knifytv | 2 | knify PLAYS: ANNO: Mutationem - Episode 4 | 30:01 |
