| 1. | dubaiandydotcom | Command and Destroy DS | 22,915 | |
| 2. |  Corrupt X | Diep.io FFA - Factory: Command and Destroy (Highlight Reel) | 14,625 | |
| 3. |  TaxOwlbear | Let's Play Command And Destroy #1 | Humans Mission 1: Enemy Approaching | 2,814 | Let's Play |
| 4. |  Il drago rosso | Command and Destroy ITA #1 "Che l'invasione abbia inizio!" | 1,936 | |
| 5. | Il drago rosso | Command and Destroy ITA #2 "Ormai il Crash è all'ordine del giorno :| " | 1,045 | |
| 6. | TaxOwlbear | Let's Play Command And Destroy #2 | Humans Mission 2: Strangers | 673 | Let's Play |
| 7. | TaxOwlbear | Let's Play Command And Destroy #24 | Aliens Mission 12: Final Battle! | 642 | |
| 8. | GamePhD | Command and Destroy • NDS Gameplay | 494 | |
| 9. | TaxOwlbear | Let's Play Command And Destroy #3 | Humans Mission 3: Blood And Steel | 397 | Let's Play |
| 10. | TaxOwlbear | Let's Play Command And Destroy #13 | Aliens Mission 1: First Contact | 390 | Let's Play |
| 11. |  The Tenth Art | Nintendo DS - Command and Destroy 'Title & Gameplay' | 380 | |
| 12. | TaxOwlbear | Let's Play Command And Destroy #5 | Humans Mission 5: Defend And Conquer | 366 | Let's Play |
| 13. | TaxOwlbear | Let's Play Command And Destroy #12 | Humans Mission 12: Wipe Them All Out! | 335 | Let's Play |
| 14. | TaxOwlbear | Let's Play Command And Destroy #6 | Humans Mission 6: Bad Day | 326 | Let's Play |
| 15. | TaxOwlbear | Let's Play Command And Destroy #7 | Humans Mission 7: Tough Day | 302 | Let's Play |
| 16. | TaxOwlbear | Let's Play Command And Destroy #4 | Humans Mission 4: Revenge | 296 | Let's Play |
| 17. | TaxOwlbear | Let's Play Command And Destroy #10 | Humans Mission 10: New Chance | 291 | Let's Play |
| 18. | TaxOwlbear | Let's Play Command And Destroy #8 | Humans Mission 8: Rescue | 277 | Let's Play |
| 19. | TaxOwlbear | Let's Play Command And Destroy #9 | Humans Mission 9: Survive And Crush | 258 | Let's Play |
| 20. | TaxOwlbear | Let's Play Command And Destroy #11 | Humans Mission 11 | 210 | Let's Play |
| 21. | TaxOwlbear | Let's Play Command And Destroy #18 | Aliens Mission 6: Mind Vs Brain | 196 | |
| 22. | TaxOwlbear | Let's Play Command And Destroy #14 | Aliens Mission 2: Invasion | 183 | Let's Play |
| 23. |  KK Nintendo DS Game | Command and Destroy (US) | 182 | |
| 24. | TaxOwlbear | Let's Play Command And Destroy #23 | Aliens Mission 11: Art Of Assimilation | 173 | |
| 25. | TaxOwlbear | Let's Play Command And Destroy #19 | Aliens Mission 7: Real Nightmare | 165 | |
| 26. | TaxOwlbear | Let's Play Command And Destroy #20 | Aliens Mission 8: In The Trap | 160 | |
| 27. | TaxOwlbear | Let's Play Command And Destroy #21 | Aliens Mission 9: Burn Them All | 155 | |
| 28. | TaxOwlbear | Let's Play Command And Destroy #17 | Aliens Mission 5: Dark Sun | 154 | |
| 29. | TaxOwlbear | Let's Play Command And Destroy #22 | Aliens Mission 10: Utopia | 153 | |
| 30. | TaxOwlbear | Let's Play Command And Destroy #16 | Aliens Mission 4: Natural Born Aliens | 147 | Let's Play |
| 31. | TaxOwlbear | Let's Play Command And Destroy #15 | Aliens Mission 3: Crimson Skies | 146 | Let's Play |
| 32. | The Videogame Clerk | Command and Destroy USA - Nintendo DS Gameplay | 102 | |
| 33. | Now Loading Please Wait | Command and Destroy USA - Nintendo DS - Play in your Xbox One or Series! | 72 | |
| 34. | ShantyPhantom | Madden 15: Command and Destroy | 33 | |
| 35. |  Gamer Linear | Command And Destroy Gameplay Nintendo DS | 27 | |
