| 1. |  Sargon of Akkad | Let's Play: Depression Quest #GamerGate #NotYourShield | 1,158 | Let's Play |
| 2. |  Dev (ShortFatOtaku) | Zoe Quinn and Gaming Journalism! -- Let's Play Depression Quest! -- No Talent Gaming | 118 | Let's Play |
| 3. | CeriGotGame | Why Gamers Suck: A Facebook/Cracked Saga | 56 | Let's Play |
| 4. | FiyahKitteh - Gaming With Your Favorite Cat Girl | Depression Quest Video Game #2 - Lack Of Motivation | Depression Simulation Game | FiyahKitteh | 8 | Let's Play |
| 5. |  KrazyCries | Krazy Plays Depression Quest || Be Careful When Watching! (P1) | 8 | Let's Play |
| 6. | FiyahKitteh - Gaming With Your Favorite Cat Girl | Depression Quest Video Game #3 - They Are Not Listening | Depression Simulation Game | FiyahKitteh | 7 | Let's Play |
| 7. | Old World Gamer | Depression Quest P1 | 7 | Let's Play |
| 8. | FiyahKitteh - Gaming With Your Favorite Cat Girl | Depression Quest Video Game #4 - Seeing A Professional | Depression Simulation Game | FiyahKitteh | 7 | Let's Play |
| 9. | FiyahKitteh - Gaming With Your Favorite Cat Girl | Depression Quest Video Game #6 - External Pressure | Depression Simulation Game | FiyahKitteh | 7 | Let's Play |
| 10. | FiyahKitteh - Gaming With Your Favorite Cat Girl | Depression Quest Video Game #5 - Self-Bribing | Depression Simulation Game | FiyahKitteh | 6 | Let's Play |
| 11. | FiyahKitteh - Gaming With Your Favorite Cat Girl | Depression Quest Video Game #8 - Romantic Relationships | Depression Simulation Game | FiyahKitteh | 6 | Let's Play |
| 12. | Tengu Drop | Depression Quest | 6 | Let's Play |
| 13. | FiyahKitteh - Gaming With Your Favorite Cat Girl | Depression Quest Video Game #1 - The Basics | Depression Simulation Game | FiyahKitteh | 5 | Let's Play |
| 14. | FiyahKitteh - Gaming With Your Favorite Cat Girl | Depression Quest Video Game #7 - Meds And Sideeffects | Depression Simulation Game | FiyahKitteh | 4 | Let's Play |
| 15. | 80% Relatable | Two Queers Play Depression Quest | Get in the Fucking Robot | 4 | Let's Play |
| 16. | WahWahQueenMew | Story Time! ft. Depression- Depression Quest | 4 | Let's Play |
| 17. | Old World Gamer | Depression Quest P4 | 2 | Let's Play |
| 18. | Old World Gamer | Depression Quest P2 | 2 | Let's Play |
| 19. | FiyahKitteh - Gaming With Your Favorite Cat Girl | Depression Quest Video Game #9 - Always Keep Fighting | Depression Simulation Game | FiyahKitteh | 2 | Let's Play |
| 20. | The Edgy Penguin | MEDIA WARS: Video Games (Cold Contempt S1 E7) | 1 | Let's Play |
| 21. |  PolishLynx | Depression Quest - Attick with the help [Part 4] | 1 | Let's Play |
