| 1. |  SuperHorrorBro | Mario Unleashes the Horrors of his Lab || Dr. Mario's Lab (Playthrough) | 428 | Let's Play |
| 2. | Betty Horde Clinic | Pick Up's February 2021 | 127 | |
| 3. | Michael Mac | Dr. Mario - Fever (Guitar Remix) | 58 | |
| 4. | Larry Bundy Jr | Nintendobo: Dr. Mario says Eat Mommy's Pills | 27 | |
| 5. | JDubDotEXE | One Hour Game Music: Dr. Mario - Chill for 1 Hour | 25 | |
| 6. | Ediz And Ben | What if Princess Zelda, Dr Mario + Pichu were replaced with Disney characters? #DisneySmashBros | 23 | |
| 7. | The Laird's Lair | Four Play - Dr. Mario - 8-bit Computer Comparison | 18 | |
| 8. | VG Music Mashup | Dr Mario Mode Select Theme Mashup (NES/Dr. Mario 64/Dr. Luigi) | 17 | |
| 9. | StevieROM | Dr. Mario / Nes / 1990 / Retro Replay | 16 | |
| 10. | The Laird's Lair | Four Play - Dr. Mario - 8-bit Console Comparison | 14 | |
| 11. | SupaGoGoMan | Forgot my scrubs | 14 | |
| 12. | Bloops' Vault | Dr. Mario Is a Terrible Game To Play While Sick ft. The Flu | 14 | |
| 13. | 2PlayerParty | Doctor Mario! - Answering weird work questions? | 14 | |
| 14. | MyYouTubeChannel | Game Boy Reviews - Dr Mario | 12 | Review |
| 15. | Zeusdaz - The Unemulated Retro Game Channel | DR. MARIO (AMIGA) | 11 | |
| 16. | The Laird's Lair | Four Play - Dr. Mario - 16-bit Comparison | 10 | |
| 17. | John Gage | Dr. Mario Review for the NES by John Gage | 8 | Review |
| 18. | KeyAO Games | This level was SO DIFFICULT yet SO FUN! #GPW3 #SMW #Gaming #Shorts | 8 | |
| 19. | John Gage | Dr. Mario Review for the SNES by John Gage | 8 | Review |
| 20. | BlueJackG Channel | Dr. Mario [Remix] - Chill Out Mario! (Chill Cover) | 7 | |
| 21. | Skyaab | DrMario.EXE | 6 | |
| 22. | Littlebigdan | The birthday boy is fighting his tablets (Dr Mario) | 6 | |
| 23. | Shiba Mashups! | [Dr. Mario Theme] - Michael Rosen Mashup | 5 | |
| 24. | NintendoSwitchGuru | Nintendo 3Ds e Shop Update 22nd March 2012 + Pyramids Demo + DR Mario + | 5 | Vlog |
| 25. | Gonzo RedSuns | HAPPY Miis with BOB ROSS - Dr Mario and Ricky Berwick | 5 | |
| 26. | NintendoExtremists | Channel Update - April 2021 | 4 | Vlog |
| 27. | World Minus 1 Entertainment | Dr. Mario (NES) - Killing Viruses Through Levels 0-10 | 4 | |
| 28. | The Gamesmaster Ghetto | Commodore 64 - Dr Maria (2023) Dr Mario Clone!! | 3 | |
| 29. | Silent Peak Gaming | Sky-High Sundae T Dr Mario gameplay⭐️🍄 | 3 | |
| 30. | Bo55 Fatwod | MARIO HAS TURNED GIANT AND WANTS TO KILL LUIGI || Dr Marios Lab | 3 | |
| 31. | Theta Eisenberg | It's a me over used plumber 😂 | 3 | |
| 32. | Gawny7789 | Livestream - Gameboy games! | 2 | |
| 33. | Robchuckle | Happy 20TH Anniversary To GameBoy Advance With Robchuckle And Friends 22ND March! 🎮🕹🖥💻📱 | 2 | |
| 34. | Bare Buddies | Fat mistakes - Dr. Mario - #3 - Bare Buddies | 2 | |
| 35. | GameDev.tv | ON THIS DAY💊 Dr. Mario Dosed Japanese TV's in 1990 #shorts #youtubeshorts #youtubegaming | 2 | |
| 36. | SuperBloxTube | Mariokart: The Animated Series | Episode 66 | Doctor! | 2 | |
| 37. | MrSmegheneghan | A Short Visit to the Italian Doctor | 2 | |
| 38. | Mackay81 TV | Doctor Mario Joke 🤣🕹 #gaming #meme #funny #jokes #viral #retrogaming #nintendo #trending #shorts | 2 | |
| 39. | Mega_Browner | Darth_Browner Reviews: Dr. Mario | 2 | Review |
| 40. | Tomiato64 | Dr Mario amiibo Gameplay | 1 | |
| 41. | OtakuAtariGamer | Quick Playthroughs #1: Dr Mario (Gameboy, 1990) | 1 | Let's Play |
| 42. | Big Cals World | Nintendo Classic Mini Review #8 - Dr Mario | 1 | Review |
| 43. | Jatendo | I got every single spotlight in this GOLD PIPE!!! (Dr. Mario Pipe) | 1 | |
| 44. | Luk & Lok | Lets Go Retro! - Dr Mario (NES: 1990) | 1 | |
| 45. | Silent Peak Gaming | 🦠🧬Dr Mario on call🧬🦠#shorts | 1 | |
| 46. | Retrodude | Dr. Mario NES - Livestream | 1 | |
| 47. | Silent Peak Gaming | 🍄Dr Mario blocks a shell attack🤯😱👀#ytshorts | 1 | |
| 48. | RetroJustPlay | RetroJustPlay Retron 5 Dr Mario | 1 | |
| 49. | 3DBrawl114 | 3DB: Dr Mario's Pet Yoshi | 1 | |
