| 1. |  brentalfloss | Dr. Mario WITH LYRICS - brentalfloss | 11,576 | |
| 2. | ZeRo | 【Analysis】Is Dr Mario Viable In Tournaments? - ZeRo | 1,321 | |
| 3. | GameGrumps | Dr. Mario: Synchronized Goopage - PART 2 - Grumpcade | 1,311 | |
| 4. | Raz0r13 | Clone Wars: Mario VS. Dr Mario (The Differences) | 1,306 | |
| 5. | AngryJoeShow | AJS News - Shenmue 3 Pre-Orders, Dr. Mario Microtransactions, Ubisoft Bans, Switch Lite Details! | 1,210 | |
| 6. |  TetraBitGaming | Dr. Mario (Series) LOST BITS | Unused Content and Debug Modes [TetraBitGaming] | 963 | |
| 7. | ZeRo | 【Analysis】Dr Mario - ZeRo (Ft. Wii U GIVEAWAY! Check Description!) | 876 | |
| 8. | kiro talks | The Sadly Forgotten Mario Series | 844 | |
| 9. | Nintendo Unity | Evolution of Dr. Mario (1990 - 2018) | 839 | |
| 10. | Arlo | DK Movie Rumor, Sakurai on Smash's Future, Dr. Mario Dead | NINTENDO NEWS ROUNDUP | 806 | |
| 11. | GameGrumps | Dr. Mario: Maximum Goopage - PART 4 - Grumpcade | 753 | |
| 12. |  もこうの実況 | マリカーよりマリメよりストレス無い最高なゲーム見つけてしまった。【実況|ドクターマリオ doctor mario】 | 734 | |
| 13. | GameXplain | Nintendo Kills Dr. Mario...World! Mobile Game To End Soon | 724 | |
| 14. | GameGrumps | Dr. Mario: Attitude Adjustment - PART 3 - Grumpcade | 715 | |
| 15. | Cinemassacre | Dr Mario LEVEL 20 - James & Mike Mondays | 714 | |
| 16. | Vinesauce: The Full Sauce | Vinny - Mario.exe Pack | 706 | |
| 17. | Lockstin & Gnoggin | Mario Theory: Is Mario Really a Doctor? | Gnoggin | 702 | |
| 18. |  MonsterDroiid | Dr Mario Ya Disponible💊 Fortnite, Minecraft, Dragon Ball, RE - Noticias y Juegos Nuevos Android iOS | 693 | |
| 19. | GTLive | Can I Escape The HORROR Of Dr. Mario?! | Dr. Mario's Lab (Scary Fangame) | 675 | |
| 20. |  Julien Neel | DR MARIO A CAPPELLA - FEVER THEME - Trudbol & Vit Soural | 634 | |
| 21. | brentalfloss | Top 10 Overlooked NES Themes PART 3 | 627 | |
| 22. |  Robzi | ЭТО РЕАЛЬНО СТРАШНО! ЛАБОРАТОРИЯ ДОКТОРА МАРИО! DR MARIO'S LAB | 613 | |
| 23. |  retrosutra | Dr. Mario | Versions Comparison | Game Boy, GBA, NES, Arcade, SNES, Wii, 3DS and more | 557 | |
| 24. | Danikyo Express | Pantallas antipiratería en videojuegos parte 42 - Dr Mario 3DS | 542 | |
| 25. | MonsterDroiid | COD Mobile, Dr Mario, KOF C, PUBG Mobile 0.13.5 - Noticias y Juegos Nuevos Android iOS | 538 | |
| 26. | GBelair | Dr. Mario (NES) Music - Fever Theme | 534 | |
| 27. | Yael Pena | Dr. Mario is Dank, Better Nerf - Super Smash Bros. For Wii U Montage | 498 | |
| 28. |  Lessons in Meme Culture | The Dr Mario Lore Is Insane | 487 | |
| 29. | Ludvix | Broken Doctor Mario | 478 | |
| 30. |  SuperHorrorBro | Mario Unleashes the Horrors of his Lab || Dr. Mario's Lab (Playthrough) | 428 | Let's Play |
| 31. | Gaming History Source | Let's Compare ( Dr. Mario ) | 420 | |
| 32. | ReviewTechUSA | A Major Update To The Nintendo Switch DRM Situation | 403 | Vlog |
| 33. | Kosmic | Name That Tune - Nintendo Edition! | 403 | |
| 34. | World of Longplays | NES Longplay [424] Dr Mario | 398 | |
| 35. | 2ndJerma | The Knockoff Entertainment System | 384 | |
| 36. | ゲーム音楽耐久動画集 2nd season | 【30分耐久】FC ドクターマリオ FEVER NES Dr.MARIO | 379 | |
| 37. | Master0fHyrule | Evolution Of Dr. Mario In Super Smash Bros Series (Moveset, Animations & More) | 352 | |
| 38. | Zach B | DR. MARIO RAP │ Zach B | 339 | |
| 39. | ZeRo | The ZeRo Dr. Mario Challenge | 338 | |
| 40. | AwesomeMarioBros | AMB - Dr. Mario! | 323 | |
| 41. | Nin10doland | Nintendo Has NOT Forgotten About Mario... | 320 | |
| 42. | ZeRo | Dr. Mario Salt (vs. Cosmos) | 314 | |
| 43. |  Eleven | TETRIS Z PIGUŁKAMI | Dr. Mario (w/ Weza) | 307 | |
| 44. | GameXplain | NES Online December Tour (Dr Mario & Metroid SP, Ninja Gaiden, Wario's Woods & Adventures of Lolo) | 291 | |
| 45. | bintroll | 【ドクターマリオ】やっぱりマリオは面白い | 289 | |
| 46. | retrosutra | Dr Mario - Clones Comparison - Part I | 278 | |
| 47. |  PikaLoli | ماريو صار مرعب 😭💔 ( مختبر ماريو ) | Dr. Mario's Lab | 273 | |
| 48. |  Pepe el Mago Juega | ALGO TERRIBLE LE HA PASADO A MARIO... - Dr Mario's Lab con Pepe el Mago | 271 | |
| 49. | farfromsubtle | Dr. Mario - Awesome Video Games! | 265 | |
| 50. |  Megadriveanos | Caçada Gamer 003 (Feira de Acari) | 246 | |
| 51. | Pepe el Mago Juega | TOAD.EXE Y DR MARIO.EXE ?!? - Videojuegos Aterradores con Pepe el Mago | 241 | |
| 52. | Northernlion | Turns Out Tetris and Dr. Mario Are Two Different Games (Golden Goblet - Day Five) | 239 | |
| 53. | GameXplain | 15 Minutes of Brain Training for Nintendo Switch Gameplay (Dr. Mario, IR Roshambo!) | 236 | |
| 54. |  NerdOverNews | Auch Nintendo hat DRM und Always On - Meinung | 231 | |
| 55. | HalDanGhor | Dr. Mario NES Hi-Speed Level 20!!! | 218 | |
| 56. |  SiIvaGunner | Dr. Mario Theme - Tetris & Dr. Mario | 214 | |
| 57. | DONER | La TEORÍA sobre QUIÉN ES DR. MARIO | 199 | |
| 58. | The Resellers | Dr. Mario's hospital: Sonic the Hedgehog is sick - GuizDP | 199 | |
| 59. | John Hancock | 10 Good & Cheap NES Games Still Found Today | 187 | |
| 60. | Classic Game Room | Classic Game Room - DR. MARIO Nintendo Game Boy review | 184 | Review |
| 61. | meGAME | Phân Tích Game: Dr. Mario's Lab - Ăn Nấm Phiên Bản Kinh Dị | meGAME | 180 | |
| 62. | AbdallahSmash | NES Classic Edition - Gameplay Of ALL 30 Games, Review, & Size Comparison! | 178 | Review |
| 63. | GodOfCoffee | Dr. Mario's Lab (Juego de Terror) | Toda la Historia en 10 Minutos | 176 | |
| 64. | Behind the Games | 🔥¡ESTE AÑO SWITCH MINI con MICROPAGOS! ¿WTF? | ¡JUEGO SORPRESA en 2019! | Switch Online - Dr.Mario | 174 | |
| 65. | DKOldies.com | Mario Goes Viral! | 171 | |
| 66. |  Pro Gamer | DR. Mario (NES 1990) Gameplay | 170 | |
| 67. | GBelair | Dr. Mario (NES) Music - Chill Theme | 168 | |
| 68. | dwangoAC, keeper of TASBot | TASBot takes doping viruses a bit too far in Dr. Mario at ESA (European Speedrunner Assembly) | 166 | |
| 69. | Alex.EXE | Moveset Animation Comparison | DR. MARIO | 166 | |
| 70. | John Hancock | Atari 8-bit Computer Games that You MUST PLAY | 166 | |
| 71. |  Mariuigi Khed - I PixelGamers | SMG4 ITA: Una tripla dose di Dr. Mario | 157 | |
| 72. | GBelair | Dr. Mario (NES) Music - Title Theme | 153 | |
| 73. | 熱血テレビゲーム チャンネル / Nekketsu TV Game Channel | （FC）ドクターマリオ ハイのレベル20～ | Dr.Mario Hi Lv20~(NES) | 152 | |
| 74. | Underdogs Gaming | we discovered an OVERPOWERED Dr. Mario combo... | 150 | |
| 75. | アルメイダちゃんねる ーAlmeida channelー | ＜凄技＞GB／ドクターマリオ(レベル20＆スピードHI)クリア動画 Dr.MARIO | 149 | |
| 76. |  Group M Pro | Dr. Mario (1990) Gameboy vs NES vs Arcade vs SNES vs GBA vs N64 vs Gamecube vs 3DS | 147 | |
| 77. | farfromsubtle | Awesome Video Games - Episode 29 - Dr. Mario pt.1 | 144 | |
| 78. | DKOldies.com | Can You Play Game Boy Games on the N64? | 142 | |
| 79. | Hungry Goriya | Bad Video Game Science - Dr. Mario for NES, Game Boy, SNES | hungrygoriya | 141 | |
| 80. | LITTELリテル | 【ゆっくり実況】スマブラSP実況 やるしかない！ Dr マリオVSスネーク | 137 | |
| 81. | Sunbro Nation | Nintendo Does The RIGHT THING For Switch Users! + Switch DRM Situation UPDATE... | 132 | Vlog |
| 82. |  GameBoyle | Boyographic - Dr. Mario Game Boy Review | 127 | Review |
| 83. | Betty Horde Clinic | Pick Up's February 2021 | 127 | |
| 84. | pojr | This Mario Game Was NOT Released in Japan | 125 | |
| 85. | BlueMoon95 | Dr.Mario (NES) - Game Over | 124 | |
| 86. | Frog Tony | Ian Ferguson SLANDERED by Former Intellivision Amicos! | 123 | |
| 87. | Club Nientiendo | Dr. Mario - Retro Reseña | 122 | |
| 88. | World of Longplays | Game Boy Longplay [087] Dr. Mario | 122 | |
| 89. | Sharkey boi | SB Movie: Shark Puppet plays Dr Mario’s Lab! | 119 | Let's Play |
| 90. | Rumble Pad | Dr. MARIO : L'affrontement final ! - QPN | 119 | |
| 91. | カナメとハルキー | ウィルスを駆逐せよ！ドクターマリオ【カナハルレトロゲー】 | 115 | |
| 92. | KindKing01 | - ̗̀ Dr. Mario Amiibo Giveaway ̖́- | 114 | |
| 93. | 周央 サンゴ / Suo Sango【にじさんじ】 | 【ドクターマリオ】ワ ク チ ン ゴ ね ぇ【周央サンゴ】 | 113 | |
| 94. | retrosutra | Dr. Mario - Clones Comparison (Part 2) | 111 | |
| 95. | AdamzoneTopMarks | What Happens If GIANTESS GIRLS Fight DR. MARIO? - Super Smash Bros | 110 | |
| 96. | GBelair | Dr. Mario (NES) Music - Versus Victory | 110 | |
| 97. | John Hancock | Retrogaming is Alive and Thriving in Ohio | 108 | |
| 98. | Nintendo of America | Nintendo eShop - Dr. Mario on the Wii U Virtual Console | 107 | |
| 99. | Tripolar | Minecraft Wii U - Super Mario Series - Evil Dr. Mario [26] | 105 | |
| 100. |  Mundo N | SECRETOS de Nintendo que SOLO el 0,1% de los jugadores CONOCE | 105 | |
