| 1. |  TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 1 EPIC OPENING & Prologue Let's Play | 1,645,985 | Let's Play |
| 2. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 2 The Illusive Man Let's Play | 317,019 | Let's Play |
| 3. |  Digital Foundry | Mass Effect 2 Xbox 360 vs. PlayStation 3 Demo Comparison | 279,508 | Let's Play |
| 4. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 3 The Normandy II Let's Play | 243,348 | Let's Play |
| 5. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 4 Crew Conversations #1 Let's Play | 198,372 | Let's Play |
| 6. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 5 Citadel and Spectre Status Let's Play | 191,783 | Let's Play |
| 7. | ChristopherOdd | Mr. Odd - Let's Play Mass Effect 2 - Part 1 - Odd Shephard is Back! | 185,938 | Let's Play |
| 8. |  zaaap! | My Horse And Me 2: Showdown in Kentucky - ENDE - #14 | Let's Play ★ [GERMAN/DEUTSCH] | 181,971 | Let's Play |
| 9. |  SargeThePlayer | Zagrajmy w Mass Effect 2 [60 fps] odc. 1 - Drugie życie Sheparda | 165,636 | Let's Play |
| 10. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 57 Suicide Mission Ending Let's Play | 147,044 | Let's Play |
| 11. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 6 Gettin' Slizzard Let's Play | 139,791 | Let's Play |
| 12. |  Game Movie Land | MASS EFFECT 2 - FILM JEU COMPLET FRANCAIS | 134,982 | Let's Play |
| 13. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 7 Omega Aria T'Loak Let's Play | 131,602 | Let's Play |
| 14. | darksydephil | Mass Effect 2 HD playthrough pt1 | 127,373 | Let's Play |
| 15. | Toegoff | Let's Play Mass Effect 2 - Part 1: Not a Great Start | 116,030 | Let's Play |
| 16. | WhatCulture Gaming | 8 Best Video Game Endings You Will Never See On A First Playthrough | 114,978 | Let's Play |
| 17. | zaaap! | My Horse And Me 2: Unser erstes Turnier #3 | Let's Play ★ [GERMAN/DEUTSCH] | 114,801 | Let's Play |
| 18. | darksydephil | Mass Effect 2 HD playthrough pt2 | 114,481 | Let's Play |
| 19. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 8 Save the Archangel Let's Play | 112,537 | Let's Play |
| 20. | zaaap! | My Horse And Me 2: Das Turnier in Australien #5 | Let's Play ★ [GERMAN/DEUTSCH] | 111,662 | Let's Play |
| 21. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 9 Boss Battle Tarak Let's Play | 101,773 | Let's Play |
| 22. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 14 Cerberus Operative Rescue Let's Play | 101,327 | Let's Play |
| 23. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 10 Omega Plague Let's Play | 97,155 | Let's Play |
| 24. |  ExVSK | Mass Effect 2 - Playthrough #1 [FR] | 92,273 | Let's Play |
| 25. | EmoPrinny | Mass Effect Xbox 360 Playthrough Part 1 | 89,872 | Let's Play |
| 26. | DarkDrumProductions | Mass Effect 2 - Help Thane (Loyalty Mission) - Following Joram Talid | 87,344 | Let's Play |
| 27. | SidAlpha | ACERTHORN LAWSUIT IS OVER! We Won! Judge THREW THE CASE OUT | 87,204 | Let's Play |
| 28. | darksydephil | Mass Effect 2 Collector's Edition Unboxing (preview to playthrough) | 86,756 | Let's Play |
| 29. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 11 Recruit Dr. Mordin Let's Play | 85,852 | Let's Play |
| 30. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 12 Plague Virus Let's Play | 84,888 | Let's Play |
| 31. | zaaap! | My Horse And Me 2: Weiter geht's nach Frankreich #6 | Let's Play ★ [GERMAN/DEUTSCH] | 84,714 | Let's Play |
| 32. | darksydephil | Mass Effect 2 HD playthrough pt3 | 84,457 | Let's Play |
| 33. | Raketenjansel | Die 10 BESTEN PS3 SPIELE | 81,154 | Let's Play |
| 34. | ChristopherOdd | Mr. Odd - Let's Play Mass Effect 2 - Part 2 - Old Friend! And Veetor... | 80,943 | Let's Play |
| 35. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 20 Normandy Crash Site Let's Play | 78,890 | Let's Play |
| 36. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 16 Prison Ship Purgatory Let's Play | 78,773 | Let's Play |
| 37. | darksydephil | Mass Effect 2 HD playthrough pt4 | 76,952 | Let's Play |
| 38. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 15 Recruit the Krogan Let's Play | 75,484 | Let's Play |
| 39. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 13 Upgrades & Power Couplings Let's Play | 75,272 | Let's Play |
| 40. | zaaap! | My Horse And Me 2: Ein komischer Typ #4 | Let's Play ★ [GERMAN/DEUTSCH] | 73,231 | Let's Play |
| 41. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 19 Collector Tower Defence Let's Play | 73,025 | Let's Play |
| 42. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 17 Recruit Jack Let's Play | 70,928 | Let's Play |
| 43. | ChristopherOdd | Mr. Odd - Let's Play Mass Effect 2 - Part 3 - Who is the Illusive Man? | 70,575 | Let's Play |
| 44. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 23 Recruit Kasumi Let's Play | 68,459 | Let's Play |
| 45. | Schaly | Let's Play Mass Effect 2 (blind) - Part 01: What the Hell!? | 67,611 | Let's Play |
| 46. |  Official EA UK | Mass Effect 2 - Launch Trailer [PlayStation 3] | 67,397 | Let's Play |
| 47. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 18 Activate the Krogan Let's Play | 66,548 | Let's Play |
| 48. | ChristopherOdd | Mr. Odd - Let's Play Mass Effect 2 - Part 6 - So That's Archangel! | 66,500 | Let's Play |
| 49. | FlamingGnats | Mass Effect 2 Playthrough - Part 1 (Opening) | 65,602 | Let's Play |
| 50. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 21 Rescue Tali Let's Play | 65,446 | Let's Play |
| 51. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 31 Collector Base Let's Play | 64,928 | Let's Play |
| 52. | ChristopherOdd | Mr. Odd - Let's Play Mass Effect 2 - Part 4 - New Faces, Old Ship | 64,550 | Let's Play |
| 53. | Toegoff | Let's Play Mass Effect 2 - Part 2: We Shall Rebuild Him | 63,892 | Let's Play |
| 54. | darksydephil | Mass Effect 2 HD playthrough pt5 | 62,373 | Let's Play |
| 55. | ChristopherOdd | Mr. Odd - Let's Play Mass Effect 2 - Part 63 - Finale [Twitch Archive] | 62,252 | Let's Play |
| 56. | ChristopherOdd | Mr. Odd - Let's Play Mass Effect 2 - Part 5 - Aria T'Loak "I Am Omega" | 61,790 | Let's Play |
| 57. | ChristopherOdd | Mr. Odd - Let's Play Mass Effect 2 - Part 7 - Drinking with Chakwas | 59,272 | Let's Play |
| 58. | Angel Alyx | SHEPARD IS BACK | Mass Effect 2 Legendary Edition Let's Play Part 1 | 59,120 | Let's Play |
| 59. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 22 Geth Colossus Let's Play | 58,676 | Let's Play |
| 60. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 30 Grunt's Ritual Let's Play | 58,235 | Let's Play |
| 61. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 26 Recruit Zaeed Let's Play | 58,143 | Let's Play |
| 62. | SargeThePlayer | Zagrajmy w Mass Effect 2 [60 fps] odc. 2 - Pierwsze spotkanie z Jacobem i Mirandą | 57,432 | Let's Play |
| 63. | xcalizorz | Mass Effect 2 Playthrough pt.1 | 56,744 | Let's Play |
| 64. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 25 Boss Donovan Hock Let's Play | 54,826 | Let's Play |
| 65. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 24 Party Crasher Let's Play | 54,559 | Let's Play |
| 66. | darksydephil | Mass Effect 2 HD playthrough pt175 (final) | 53,400 | Let's Play |
| 67. | darksydephil | Mass Effect 2 HD playthrough pt6 | 53,349 | Let's Play |
| 68. | ChristopherOdd | Mr. Odd - Let's Play Mass Effect 2 - Part 8 - The Disease Heard Round The World | 52,916 | Let's Play |
| 69. | zaaap! | My Horse And Me 2: Süße, aber nervige Mini-Spiele #12 | Let's Play ★ [GERMAN/DEUTSCH] | 52,715 | Let's Play |
| 70. | ChristopherOdd | Mr. Odd - Let's Play Mass Effect 2 - Part 9 - Delivering Mordin's Cure | 52,413 | Let's Play |
| 71. | darksydephil | Mass Effect 2 HD playthrough pt7 | 51,647 | Let's Play |
| 72. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 56 Prepare for Battle Let's Play | 51,178 | Let's Play |
| 73. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 53 Reaper IFF Let's Play | 51,024 | Let's Play |
| 74. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 54 Recruit Legion Let's Play | 51,004 | Let's Play |
| 75. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 33 Miranda's Sister Let's Play | 50,775 | Let's Play |
| 76. | LobosJr | Mass Effect Paragon Playthrough (Pt. 1) | 50,772 | Let's Play |
| 77. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 27 Krogan Home World Let's Play | 50,627 | Let's Play |
| 78. | ChristopherOdd | Mr. Odd - Let's Play Mass Effect 2 - Part 10 - Upgrades and Zaeed | 49,390 | Let's Play |
| 79. | zaaap! | My Horse And Me 2: Sieg auf ganzer Linie #11 | Let's Play ★ [GERMAN/DEUTSCH] | 49,342 | Let's Play |
| 80. | xcalizorz | Mass Effect 2 Playthrough pt.2 | 49,200 | Let's Play |
| 81. | darksydephil | Mass Effect 2 HD playthrough pt8 | 48,987 | Let's Play |
| 82. | ChristopherOdd | Mr. Odd - Let's Play Mass Effect 2 - Part 12 - Kasumi The Master Thief | 48,574 | Let's Play |
| 83. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 35 Tali's Trial Let's Play | 47,723 | Let's Play |
| 84. | ChristopherOdd | Mr. Odd - Let's Play Mass Effect 2 - Part 11 - Aria and the Patriarch | 47,472 | Let's Play |
| 85. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 32 Confront the Illusive Man Let's Play | 47,094 | Let's Play |
| 86. | darksydephil | Mass Effect 2 HD playthrough pt10 | 47,036 | Let's Play |
| 87. | ChristopherOdd | Mr. Odd - Let's Play Mass Effect 2 - Part 13 - The Council Sure Is Grateful | 46,343 | Let's Play |
| 88. | Toegoff | Let's Play Mass Effect 2 - Part 3: Under Attack! | 46,270 | Let's Play |
| 89. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 28 Mordin's Assistant Let's Play | 46,162 | Let's Play |
| 90. | ChristopherOdd | Mr. Odd - Let's Play Mass Effect 2 - Part 15 - Rescuing Jack! | 45,939 | Let's Play |
| 91. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 29 Krogan Shaman Let's Play | 45,807 | Let's Play |
| 92. | CohhCarnage | CohhCarnage Plays Mass Effect 2 - Episode 1 | 45,742 | Let's Play |
| 93. | ChristopherOdd | Mr. Odd - Let's Play Mass Effect 2 - Part 50 - Jack, Samara, and Liara | 45,550 | Let's Play |
| 94. | darksydephil | Mass Effect 2 HD playthrough pt18 | 45,467 | Let's Play |
| 95. | SargeThePlayer | Zagrajmy w Mass Effect 2 [60 fps] odc. 3 - Człowiek Iluzja | 45,315 | Let's Play |
| 96. | darksydephil | Mass Effect 2 HD playthrough pt11 | 44,868 | Let's Play |
| 97. | Many A True Nerd | Mass Effect 2 - Part 17 - Family Reunion | 44,714 | Let's Play |
| 98. | ChristopherOdd | Mr. Odd - Let's Play Mass Effect 2 - Part 20 - It's Good To See You. I Think. | 44,665 | Let's Play |
| 99. | TetraNinja | Mass Effect 2 Gameplay Walkthrough - Part 55 Destroy or Brainwash? Let's Play | 43,991 | Let's Play |
| 100. | darksydephil | Mass Effect 2 HD playthrough pt174 | 43,826 | Let's Play |
