| 1. |  ★WishingTikal★ | 1,435,190 | Megamind The Blue Defender FULL GAME Longplay (PSP) | 3:43:47 |
| 2. | TimotheeReacts | 1,218,162 | MEGAMIND 2 IS A ABSOLUTE DISASTER! I needed a drink after watching Megamind 2 vs. the Doom Syndicate | 41:23 |
| 3. | The Theorizer | 899,787 | Megamind: A City of DECEPTION! (Metro Man: Part 1) [Theory] | 10:28 |
| 4. | CineBinge | 113,249 | Megamind | Canadian First Time Watching | Movie Reaction | Movie Review | Movie Commentary | 32:13 |
| 5. | JV's Galactic Adventures | 103,537 | MEGAMIND IS THE MOST UNDERRATED SUPERHERO MOVIE | Movie Reaction | 47:42 |
| 6. | The Rappter | 89,683 | MINION MAYHEM! Gru VS Megamind DEATH BATTLE Reaction | 0:00 |
| 7. | Nuxanor | 55,150 | Why Megamind is a Subversive Masterpiece | Nux Reacts | 49:57 |
| 8. | JoBlo Superheroes | 34,114 | MEGAMIND VS THE DOOM SYNDICATE Trailer (2024) | 1:57 |
| 9. | ElectricDragon505 | 30,740 | #Megamind vs. The Doom Syndicate is #WORSE Than You Think | 0:51 |
| 10. | TheTrends Animated | 28,780 | All VOICE ACTORS In MEGAMIND 2 Revealed | 9:39 |
| 11. | Ryychii | 10,547 | Megamind 2 is a national disgrace 🤮🤮🤮 #animation #megamind #movie | 0:22 |
| 12. | Gumwings | 3,645 | MY REACTION TO GRU VS MEGAMIND #despicableme #megamind #deathbattle #shorts | 0:00 |
| 13. | Project COE | 1,684 | E3 2010 -- Megamind Trailer | 1:10 |
| 14. | Mr Chhay | 1,486 | Megamind Ultimate Showdown – Full Game Walkthrough | 0:00 |
| 15. | Learning Paws | 689 | How To Draw Titan | MEGAMIND #shorts #shortsdrawing #drawing #megamind | 0:00 |
| 16. | Beyond Narrative | 418 | Megamind 2 Debuts With Disastrous Rotten Tomatoes Score #megamind #dreamworks | 2:22 |
| 17. | balaklava boi | 403 | THIS IS NOT MY MEGAMIND | MEGAMIND VS THE DOOM SYNDICATE | MEGAMIND 2 | TRAILER REACTION BOIII | 13:05 |
| 18. | Jay BirdBlu_117 | 343 | Megamind is Not Fooling Warden | Megamind [YTP] | 1:51 |
| 19. | Clandor's Sauce | 220 | Live action Megamind looking good! #shorts | 0:19 |
| 20. | Sophie Pajarvi | 54 | Megamind Song-"Famous" | 1:19 |
| 21. | snapbeasty2 | 35 | MEGAMIND! | 0:25 |
| 22. | Mtx0 | 32 | Megamind Edit. #megamind #movie #edit #cakebytheocean | 0:40 |
| 23. | Keiran & Aiden's World of Wonder | 24 | Og megamind 💪 #megamind #edit #moive #edits | 0:36 |
