| 1. | Movieclips | 110,971,545 | Megamind (2010) - Megamind vs. Titan Scene (10/10) | Movieclips | 2:52 |
| 2. | Rotten Tomatoes Family | 74,078,465 | Megamind - Megamind vs. Titan | Fandango Family | 2:42 |
| 3. | justmehabibi | 17,572,013 | bro wtf is the Megamind TV Show 💀 (Season 2) | 0:00 |
| 4. | Spilling The Milk | 16,844,464 | The NEW SEASON of the Megamind Show IS AWFUL... | 20:55 |
| 5. | M.Megamind | 4,895,040 | វាស់កម្តៅ៖ Megamind | 5:23 |
| 6. | Max's Manga | 4,315,849 | Can Mr. Incredible BEAT Metro Man? #theincredibles #megamind #metroman #pixar #dreamworks | 0:00 |
| 7. | DazzReviews | 3,980,656 | Watching EVERY EPISODE of Megamind Rules S2 Was A Nightmare... | 0:00 |
| 8. | Sarus | 1,828,013 | Megamind: Ultimate Showdown - Road to platino | Español | Sin comentario | Random 12 | 2:30:31 |
| 9. | ★WishingTikal★ | 1,435,190 | Megamind The Blue Defender FULL GAME Longplay (PSP) | 3:43:47 |
| 10. | Kadz | 1,434,732 | The entirety of Megamind 2 but only when ANYONE says "E" | 8:01 |
| 11. | Casey Alhambra | 1,294,066 | Megamind: The Button of Doom (2011) Final Battle with healthbars (300K Subscribers Special) | 7:11 |
| 12. | TimotheeReacts | 1,218,162 | MEGAMIND 2 IS A ABSOLUTE DISASTER! I needed a drink after watching Megamind 2 vs. the Doom Syndicate | 41:23 |
| 13. | Nathidraws | 1,135,947 | Megamind Scene Comparison - Metroman Death Scene - Real vs Flashback | 1:49 |
| 14. | The Theorizer | 899,787 | Megamind: A City of DECEPTION! (Metro Man: Part 1) [Theory] | 10:28 |
| 15. | Lessons in Meme Culture | 813,640 | Megamind 2 Does Not Look Good | 2:37 |
| 16. | AFKCLOWN | 766,074 | Megamind Vs Superman (Copies) | 0:47 |
| 17. | ZigZagGamerPt | 761,769 | Megamind Team United | FULL MOVIE GAME | ZigZag Kids HD | 3:14:25 |
| 18. | Korean Comic | 685,159 | Megamind 2 explained by an Asian | 7:36 |
| 19. | Th3Birdman | 594,723 | Everything Wrong With CinemaSins: Megamind in 17 Minutes or Less | 17:37 |
| 20. | Cody Hales | 577,462 | I Forced Myself To Watch The Megamind Sequel | 17:31 |
| 21. | Reel Rejects | 406,918 | MEGAMIND (2010) MOVIE REACTION!! FIRST TIME WATCHING!! Will Ferrell | Brad Pitt | Movie Review | 0:00 |
| 22. | Paul Wil slap u | 372,886 | MEGAMIND IS BACK BUT ITS A SHRIMP | 0:43 |
| 23. | PyroLIVE | 342,026 | Megamind 2 Looks Terrible | 9:38 |
| 24. | Seanny | 328,374 | MK1 Homelander Vs Tighten (The Boys Vs Megamind) | 0:40 |
| 25. | Designer X Gamer | 311,668 | Megamind Sequel In The Nutshell: #shorts #dreamworks #megamind #sequels #comedy | 0:56 |
| 26. | Out Of Context | 305,524 | Megamind But The Context Was Killed In The Observatory | 3:45 |
| 27. | Nico D. Zilla | 284,684 | Titan from Megamind stare, but something's wrong | 0:19 |
| 28. | Jay Films | 279,469 | Is Megamind a Top Tier Hero? - Hero Review #8 | 7:05 |
| 29. | CityofEdits | 245,054 | 3rd to last edit special | Gru vs Megamind #despicableme #megamind #vsedit #vsbattle #wis #wisedit | 0:00 |
| 30. | Vailskibum | 211,631 | Everyone HATES Megamind 2 | 3:03 |
| 31. | Fandom Entertainment | 202,153 | Megamind "Vote For Megamind" Video Official (HD) | 0:32 |
| 32. | The Homies | 186,428 | Megamind (2010) GROUP REACTION | 42:32 |
| 33. | Swallow Mii | 176,800 | Staring Titan MEME(Megamind) | 0:19 |
| 34. | Benson | 171,392 | So, you're the punk I've heard about (Megamind) | 0:07 |
| 35. | T_K_3 | 164,214 | Megamind (2010) - Metro Man Returns Scene (meme) | 0:06 |
| 36. | SLUURP | 155,432 | MEGAMIND 2 (2023) | DreamWorks | Teaser Trailer Concept | 1:59 |
| 37. | Dos Cavazos | 153,654 | *Megamind* SLAPS! Movie Reaction & Review | First Time Watching | 55:41 |
| 38. | Nifty | 143,147 | megamind - tiktok compilation | 2:31 |
| 39. | AlphaLVL∞ | 140,037 | Gru (Despicable Me) Vs. Megamind | #despicableme #megamind | 0:23 |
| 40. | Umur Tezer | 137,028 | MegaMind filminde bu ayrıntıyı fark ettiniz mi? #MegaMind #Filmlerhakkında | 0:58 |
| 41. | Sorta Stupid | 135,947 | Our First Time Watching Megamind Group REACTION | 42:36 |
| 42. | Badd Medicine | 129,858 | What a gem of a film!!! First time watching Megamind movie reaction | 56:20 |
| 43. | kibs | 126,911 | Megamind 2 looks disappointing | 2:25 |
| 44. | RichHomelessMan | 126,676 | Megamind Rules! Got Nominated for "Best Animated Series" | 1:04 |
| 45. | emmanuel_clayart | 126,204 | Megamind (clay art) #shorts #clayart #megamind #memes | 0:00 |
| 46. | 3C Films | 124,183 | So I Watched Megamind 2… (REVIEW) | 11:34 |
| 47. | Musical Journeys Thru Cinema | 120,772 | Dreamworks' Megamind Booby Traps Montage (Music Video) | 2:23 |
| 48. | PLAY Game | 119,071 | មួយថ្ងៃជាមួយ Gamers របស់ Playgame (EP.2) - Megamind | Full Video | 15:05 |
| 49. | John GodGames | 116,081 | Megamind: Bad. Blue. Brilliant. - PSP Gameplay 1080p (PPSSPP) | 15:12 |
| 50. | CineBinge | 113,249 | Megamind | Canadian First Time Watching | Movie Reaction | Movie Review | Movie Commentary | 32:13 |
| 51. | Netflix Family | 110,789 | Megamind? More like mega noob 😂 Megamind is now playing on Netflix! | 0:00 |
| 52. | JoBlo Animated Videos | 104,240 | Baby Megamind Scene | MEGAMIND (2010) Movie CLIP HD | 3:45 |
| 53. | JV's Galactic Adventures | 103,537 | MEGAMIND IS THE MOST UNDERRATED SUPERHERO MOVIE | Movie Reaction | 47:42 |
| 54. | Osiris | 100,330 | Megamind - Coffin Dance Song (Ozyrys Remix) 💥SEASON 6💥 | 2:00 |
| 55. | NickFlix | 98,134 | Watching Megamind: The Button Of Doom (2011) FOR THE FIRST TIME!! Shorts Reaction! | 10:04 |
| 56. | ParashockX | 98,014 | If I cringe, the video ends - Megamind vs The Doom Syndicate Movie | 0:46 |
| 57. | WickedBinge | 94,665 | Megamind VS The Doom Syndicate & Megamind Rules!: Good to Evil | 12:56 |
| 58. | vipmagazin Kino | 92,093 | MEGAMIND | Filmclips - Megamind vs. Metroman deutsch german [HD | 2:39 |
| 59. | CinePals | 90,230 | MEGAMIND Movie Reaction! | First Time Watch | Review & Discussion | Will Ferrell | 34:24 |
| 60. | psp300O | 86,871 | Megamind The Blue Defender psp gameplay | 6:32 |
| 61. | Know Your Meme | 85,415 | Megamind 'No B-' Meme EXPLAINED' | Aztrosist Meme Review | 2:52 |
| 62. | Playscope | 80,310 | Megamind - Starting Block - PS3 Xbox360 | 9:17 |
| 63. | Devoun | 79,795 | I Used AI To Generate REAL Megamind 2 Villains | 11:43 |
| 64. | Nathanael Sampaio | 79,160 | MEGAMENTE 2 DESTRÓI MEGAMENTE #megamente2 #megamente #megamind #shorts | 1:00 |
| 65. | Nice Dude Movie Night | 74,867 | My best friend showed me *MEGAMIND* (First time watching reaction) | 28:28 |
| 66. | Rainbowskinz | 70,972 | Megamind makeup Transformation! My favourite video I made EVER!! #shorts #megamind #dreamworks | 0:25 |
| 67. | 映画カルチュア FilmIsNow Japan | 69,694 | Megamind - Trailer | 3:18 |
| 68. | Erik Grimms | 66,363 | Quality showmanship! Megamind (movie reaction/first time watching) | 33:33 |
| 69. | Crazy Nate | 65,094 | Everything You Missed in Megamind | 8:20 |
| 70. | Portal Animasi | 62,151 | Dari MAHAKARYA Malah Jadi AMPASS!!! // MEGAMIND 2 OR MEGAMIND VS THE DOOM SYNDICATE | 9:44 |
| 71. | Group M Pro | 58,694 | Megamind (2010) NDS vs PSP vs Wii vs XBOX 360 ( Which One is Better?) | 4:51 |
| 72. | Mutch Games | 57,901 | Megamind: Mega Team Unite [102] Wii Longplay | 0:00 |
| 73. | CGRundertow | 57,622 | CGR Undertow - MEGAMIND: MEGA TEAM UNITE for Nintendo Wii Video Game Review | 3:44 |
| 74. | Nuxanor | 55,150 | Why Megamind is a Subversive Masterpiece | Nux Reacts | 49:57 |
| 75. | Quantum Edits | 55,132 | Metro man (live action) vs megamind (button of doom) #shorts | 0:22 |
| 76. | Joeybar | 54,927 | Everyone's Reaction To The New Megamind Trailer | 0:55 |
| 77. | The Rappter | 51,665 | Fan Made DEATH BATTLE Trailer: Gru VS Megamind (Illumination VS DreamWorks) | 0:15 |
| 78. | Tulok the Barbrarian | 49,630 | How to Play Megamind in Dungeons & Dragons (Dreamworks Build for D&D 5e) | 12:46 |
| 79. | Ninja.Killer | 47,704 | Dance Battle 💃🕺 Metro Man (Megamind) vs Yui Hirasawa | MONTAGEM VOZES TALENTINHO (Super Slowed) | 0:00 |
| 80. | Super Mando Live | 42,993 | Megamind 2 Is The Worst Movie Of 2024! | 8:02 |
| 81. | El Rodeo De Fran | 42,804 | ESPAÑOLES REACCIONAN A DOBLAJE LATINO VS ESPAÑOL DE MEGAMIND/MEGAMENTE - SE ESCAPA #DOBLAJES | 10:39 |
| 82. | AkinReacts | 42,238 | MEGAMIND IS AMAZING!! FIRST TIME WATCHING MEGAMIND Group Reaction | Movie Monday | 34:41 |
| 83. | Mudmunki | 40,976 | Megamind (2010) Movie WATCH ALONG! | First Time Watching! | Livestream! | 1:31:49 |
| 84. | ItsAPrimate | 40,651 | I WATCHED MEGAMIND FOR THE FIRST TIME AND IT WAS AMAZING! | 38:03 |
| 85. | WesSideLive | 37,830 | They Ruined Megamind | 4:23 |
| 86. | Dave's Gaming | 36,275 | Let's Play "MegaMind" - The Ultimate Showdown! Part 7 "Funky Disco" | 15:30 |
| 87. | Bemax - ビマックス | 36,180 | Megamind | Bemax - Like a Boss (ft. Aviados) [AMV] | 2:31 |
| 88. | TsaoShin | 36,014 | What if Megamind was FUZZY 👀 #shorts #art #megamind | 0:24 |
| 89. | Shannx | 34,918 | Megamind "Think like a Hero" | 0:08 |
| 90. | JoBlo Superheroes | 34,114 | MEGAMIND VS THE DOOM SYNDICATE Trailer (2024) | 1:57 |
| 91. | Grapeblast64 | 34,007 | Megamind VS Vector #edit #viral #vsbattle #despicableme #dreamworks #megamind #fyp #illumination | 0:27 |
| 92. | Damonx | 32,900 | Megamind (Dreamworks) Bande Annonce Française | 1:28 |
| 93. | PicSo | 32,718 | AI Remasters Dreamworks' Megamind into an Incredible Animation!🤩 #shorts | 0:16 |
| 94. | The Roundtable | 32,204 | MOANA 2 IS NOT A REAL MOVIE | 10:41 |
| 95. | Evildeadfan102 | 31,741 | Let's Play Megamind: Ultimate Showdown Part 11 (Blue Tighten Battle & Credits) | 18:06 |
| 96. | ElectricDragon505 | 30,740 | #Megamind vs. The Doom Syndicate is #WORSE Than You Think | 0:51 |
| 97. | Iuxse | 29,302 | Megamind 2 Trailer Reaction | 0:30 |
| 98. | TheTrends Animated | 28,780 | All VOICE ACTORS In MEGAMIND 2 Revealed | 9:39 |
| 99. | LongplayArchive | 28,328 | Longplay of Megamind: The Blue Defender | 2:25:05 |
| 100. | FregTheFrog | 24,425 | Megamind edit |megamind| #megamind #edits | 0:00 |