| 1. |  Th3Birdman | Everything Wrong With CinemaSins: Megamind in 17 Minutes or Less | 2,161 | |
| 2. | Spilling The Milk | we watched Megamind and its a MASTERPIECE... | 1,479 | |
| 3. | Vailskibum | Everyone HATES Megamind 2 | 1,400 | |
| 4. | Spilling The Milk | Megamind is amazingly HILARIOUS... | 1,186 | |
| 5. | Nico D. Zilla | Titan from Megamind stare, but something's wrong | 1,093 | |
| 6. | RichHomelessMan | Megamind Rules! Got Nominated for "Best Animated Series" | 1,000 | |
| 7. | Reel Rejects | MEGAMIND (2010) MOVIE REACTION!! First Time Watching! | 837 | |
| 8. | Spilling The Milk | watching The Megamind Show RUINED OUR LIVES... | 672 | Show |
| 9. | 3C Films | So I Watched Megamind 2… (REVIEW) | 623 | Review |
| 10. | Badd Medicine | What a gem of a film!!! First time watching Megamind movie reaction | 534 | |
| 11. | Spilling The Milk | The NEW SEASON of the Megamind Show IS AWFUL... | 507 | Show |
| 12. | Out of Context | Megamind But The Context Was Killed In The Observatory | 505 | |
| 13. | ParashockX | If I get disappointed, the video ends - Megamind 2 Trailer | 497 | Preview |
| 14. | Kadz | The entirety of Megamind 2 but only when ANYONE says "E" | 491 | |
| 15. | Crazy Nate | Everything You Missed in Megamind | 483 | |
| 16. | Sorta Stupid | Our First Time Watching Megamind Group REACTION | 442 | |
| 17. | NickFlix | Watching Megamind (2010) FOR THE FIRST TIME!! || Movie Reaction! | 426 | |
| 18. | Spilling The Milk | Megamind is so funny it hurts... | 413 | |
| 19. | Spilling The Milk | This NEW Megamind Show HURTS to watch... | 392 | Show |
| 20. | Tulok the Barbrarian | How to Play Megamind in Dungeons & Dragons (Dreamworks Build for D&D 5e) | 390 | |
| 21. | Spilling The Milk | we BINGED the ENTIRE Megamind Franchise... | 327 | |
| 22. | Benson | So, you're the punk I've heard about (Megamind) | 291 | |
| 23. | Dos Cavazos | *Megamind* SLAPS! Movie Reaction & Review | First Time Watching | 291 | Review |
| 24. | Nice Dude Movie Night | My best friend showed me *MEGAMIND* (First time watching reaction) | 289 | Show |
| 25. | WickedBinge | Dreamwork's MEGAMIND Characters: Good to Evil | 283 | |
| 26. | Super Beard Bros | Beard Bros Movie Reviews | Ep. #3 | Megamind | Super Beard Bowl | 251 | Review |
| 27. | WesSideLive | They Ruined Megamind | 250 | |
| 28. | ItsAPrimate | I WATCHED MEGAMIND FOR THE FIRST TIME AND IT WAS AMAZING! | 229 | |
| 29. | Joeybar | Everyone's Reaction To The New Megamind Trailer | 206 | Preview |
| 30. | Kadz | Megamind 2 Trailer but the Cringe is Counted | 190 | Preview |
| 31. | TsaoShin | What if Megamind was FUZZY 👀 #shorts #art #megamind | 188 | |
| 32. | WickedBinge | How Does THE BAD GUYS Compare to MEGAMIND? 🐺🦊🧠 | 175 | |
| 33. | Osiris | Megamind - Coffin Dance Song (Ozyrys Remix) 💥SEASON 6💥 | 167 | |
| 34. | Spilling The Milk | The Megamind Show is VERY CRINGE | 160 | Show |
| 35. | CinePals | MEGAMIND Movie Reaction! | First Time Watch | Review & Discussion | Will Ferrell | 159 | Review |
| 36. | Spilling The Milk | The Megamind Show is AWFUL | 154 | Show |
| 37. | ParashockX | If I cringe, the video ends - Megamind vs The Doom Syndicate Movie | 148 | |
| 38. | The Roundtable | MOANA 2 IS NOT A REAL MOVIE | 147 | |
| 39. | Casey Alhambra | Megamind (2010) Final Battle with healthbars | 139 | |
| 40. | Austin Burke | They RUINED Megamind | Megamind 2 Review | 110 | Review |
| 41. | Nifty | megamind - tiktok compilation | 109 | |
| 42. | Spilling The Milk | Megamind got us DOWNBAD | 108 | |
| 43. | Redrunner | VOTE For Gru VS Megamind in the Tournament of Champions!!! | 100 | |
| 44. | Kadz | Megamind 2 Trailer but I made it even more awkward than it already is | 94 | Preview |
| 45. | Kadz | Megamind 2 Trailer but only when ANYONE says "E" | 91 | Preview |
| 46. | Spilling The Milk | MEGAMIND 2 is SO PAINFUL | 86 | |
| 47. | Fandom Entertainment | Megamind "Vote For Megamind" Video Official (HD) | 85 | |
| 48. | Spilling The Milk | Megamind is FUNNIER THAN ANY MOVIE | 84 | |
| 49. | NickFlix | Watching Megamind: The Button Of Doom (2011) FOR THE FIRST TIME!! Shorts Reaction! | 81 | |
| 50. | JT Anime and Nerd | I Think Megamind Rules! RULES!!! (A Quick Discussion About Criticism Today) | 75 | Discussion |
| 51. | Spilling The Milk | The Megamind show is SO BAD IT HURTS | 74 | Show |
| 52. | Iuxse | Megamind 2 Trailer Reaction | 72 | |
| 53. | Know Your Meme | Megamind 'No B-' Meme EXPLAINED' | Aztrosist Meme Review | 72 | Review |
| 54. | WickedBinge | Megamind VS The Doom Syndicate & Megamind Rules!: Good to Evil | 72 | |
| 55. | Spilling The Milk | Megamind is so ICONIC | 70 | |
| 56. | Spilling The Milk | The Megamind show is SO BAD | 69 | Show |
| 57. | Spilling The Milk | The Megamind show is NOT FOR KIDS | 65 | Show |
| 58. | Spilling The Milk | The Megamind show is kinda fruity... | 55 | Show |
| 59. | Brian Hull Movie Reviews | The Big Problem with Megamind and the Doom Syndicate | 53 | |
| 60. | Casey Alhambra | Megamind vs. Titan (First Fight) with healthbars | 51 | |
| 61. | Brody2WD | Megamind 2 is the End of your childhood | 47 | |
| 62. | kracc bacc | ʸᵒᵘ ᵗʰⁱⁿᵏ ⁱᵗ’ˢ ʳᵉᵃˡˡʸ ᶠᵘⁿⁿʸ ʰᵘʰ? | 42 | |
| 63. | JoBlo Animated Videos | MEGAMIND Clip - "Megamind vs. Titan" (2010) | 42 | |
| 64. | Calobi Productions | Megamind Is GOOD | Megamind Reaction | 41 | |
| 65. | Maximo Esco | The Megamind Villain Theory | 39 | |
| 66. | Spilling The Milk | MEGAMIND 2 is STUPID | 37 | |
| 67. | Yesenia The Hedgehog | Shadow the Hedgehog (Megamind) Part 4: The Death Ray/He did it! | 36 | |
| 68. | LongplayArchive | Longplay of Megamind: The Blue Defender | 36 | |
| 69. | Adam Does Movies | Looking Back On Megamind - Is It A Dreamworks Classic? | 35 | |
| 70. | Mutch Games | Megamind: Ultimate Showdown [24] Xbox 360 Longplay | 34 | Show |
| 71. | Headhunter Productions | Hunter Reviews: Megamind Vs The Doom Syndicate | 34 | Review |
| 72. | Yesenia The Hedgehog | Shadow the Hedgehog (Megamind) Part 13: A Superhero Stalker | 33 | |
| 73. | Fandom Entertainment | Megamind "Meet Megamind" Featurette Official (HD) | 33 | |
| 74. | JoBlo Animated Videos | MEGAMIND Clip - "Baby Megamind" (2010) | 33 | |
| 75. | Spilling The Milk | The Megamind show is TOO MUCH | 33 | Show |
| 76. | Spilling The Milk | The Megamind show is VERY ANNOYING | 30 | Show |
| 77. | Yesenia The Hedgehog | Shadow the Hedgehog (Megamind) Part 5: Celebration | 27 | |
| 78. | Yesenia The Hedgehog | Shadow the Hedgehog (Megamind) Part 22: Happy Ending | 27 | |
| 79. | LoneWolf | Megamind Vs Titan | #megamind #dreamworks #comedy #meme #edit | 26 | |
| 80. | Spilling The Milk | The Megamind show looks LIKE PS2 FOOTAGE | 24 | Show |
| 81. | Casey Alhambra | Metro Man vs. Megamind with healthbars | 24 | |
| 82. | KinoCheck Family | MEGAMIND 2: The Doom Syndicate Trailer (2024) | 23 | Preview |
| 83. | Casey Alhambra | Megamind: The Button of Doom (2011) Final Battle with healthbars (300K Subscribers Special) | 22 | |
| 84. | Draven Mayberry | Megamind Is Back! | 22 | |
| 85. | Neo Spirit | Did You Know That In MEGAMIND | #shorts | 21 | |
| 86. | incinaback | VOTE 4 GRU VS MEGAMIND | Fan Made Death Battle Trailer: Illumination Vs Dreamworks (Gru Vs Megamind) | 20 | |
| 87. | T_K_3 | Megamind (2010) - Metro Man Returns Scene (meme) | 20 | |
| 88. | Kadz | Megamind 2 Trailer but I made it better | 20 | Preview |
| 89. | JoBlo Animated Videos | MEGAMIND Clip - "Entrance" (2010) Will Ferrell | 20 | |
| 90. | Calobi Productions | Titan is Dreamworks BEST Twist Villain ever (Megamind) | 20 | |
| 91. | Spilling The Milk | The Megamind show is TOO INSANE | 19 | Show |
| 92. | Cr3AtAL11tY | Funny megamind edit #memes #megamind #funny #edit | 16 | |
| 93. | G.S. Productions | "DreamWorks' Megamind" - Movie Review | 14 | Review |
| 94. | JoBlo Animated Videos | Baby Megamind Scene | MEGAMIND (2010) Movie CLIP HD | 14 | |
| 95. | Brocster | Megamind 2 Looks BAD! 🤢😨 #megamind #bad | 14 | |
| 96. | Behelit- 89 ( The Voice Comparison Channel) | Animated Voice Comparison- Megamind (Megamind) | 13 | |
| 97. | sprarn | I played MEGAMIND on WII... | 11 | |
| 98. | Dr. PGnGM | NEW VOICE, WHO'S THIS? Megamind 2 The Doom Syndicate Trailer Reaction #megamind2 #megamind #trailer | 11 | Preview |
| 99. | Mort's Banana Carnival | Typing Every Word of the Megamind Script Until I Finish It - [20] | 11 | |
| 100. | Musical Journeys Thru Cinema | Dreamworks' Megamind Booby Traps Montage (Music Video) | 10 | |
