| 1. |  Wanderbots | 81,623 | Let's Play Opus Magnum - PC Gameplay Part 16 - Topsy Turvy | 36:24 |
| 2. |  EnterElysium | 70,849 | OPUS MAGNUM | STAMINA POTION #03 Amazing Alchemist Game - Let's Play / Gameplay | 43:00 |
| 3. | KatherineOfSky | 30,223 | Opus Magnum Ep 1: IMPERIAL UNIVERSITY - Programming/Logic - First Look - Let's Play (Early Access) | 25:14 |
| 4. | Stuff+ | 4,420 | How Does Alchemy Work Again? | Opus Magnum - Let's Play / Gameplay | 24:46 |
| 5. | GQSmoos | 3,044 | Let's Play OPUS MAGNUM by Zachtronics #85 | SYNTHETIC MALACHITE (CENTERED PRODUCT CHALLENGE) | 1:05:05 |
| 6. | Deer Darling | 1,113 | Model Alchemist - Opus Magnum - Let's Play - Part 26 | 24:01 |
| 7. | The Proximity | 960 | Opus Magnum Adventure || E38 || Universal Solvant [Let's Play // Finale] | 59:05 |
| 8. |  Hog Play | 407 | 32 OpusMagnum Blind Reconstructed Solvent B | 11:32 |
| 9. |  Keywii Plays | 345 | Keywii Plays Opus Magnum (58) | 44:54 |
| 10. | Jerp | 166 | Jerp plays Opus Magnum pt.6 - End of Anateus is just the beginning? (2021-02-05) | 3:29:05 |
| 11. | Dad's Gaming Addiction | 149 | DGA Plays: Opus Magnum (Ep. 1 - Gameplay / Let's Play) | 23:01 |
| 12. | Nebu Pookins | 114 | Blind Let's Play - Opus Magnum Part 7 - Journal + Sigmar's Garden 2 | 3:21:38 |
| 13. | Marstead | 85 | βΆοΈ Start Playthrough - Opus Magnum [Blind] (Episode 1) | 1:02:48 |
| 14. | That Design Feel | 57 | Let's Play Opus Magnum | Part 9 | Journal Part 3 | Nostalgic Puzzle Gameplay | 2:28:56 |
| 15. | muligan | 44 | Opus Magnum 3 | Tonics and Potions | 22:52 |
| 16. | Rydo | 23 | βOpus Magnum #19 | 2:59:04 |
| 17. | Game Fanatic | 20 | Opus Magnum - Helping With The War Effort | 18:51 |
| 18. | OchiTube | 19 | Stream π¬ 2023-12-15 β’ Opus Magnum | 3:08:39 |
| 19. | ThePiPiper VODs | 6 | Opus Magnum - First Playthrough | 2:53:38 |
| 20. | Gaming With Tor | 4 | Opus Magnum | I think we can beat this today | Part 4 | 2:10:08 |
