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| 5. |  RanguGamer | 69,608 | LP Layton y La Caja de Pandora 10 Atrapados Juntos | 48:55 |
| 6. | NRWBoy18 | 56,507 | Lets Play Together - Prof. Layton und die Schatulle der Pandora [Bonus-Teil 1] | 14:00 |
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| 9. |  Matrik On Stage | 10,033 | Let's Play Professor Layton & the Diabolical Box #46 -Finale! [Blind] | 42:43 |
| 10. |  Raxby | 9,879 | Professor Layton and Pandora's Box — Part 27 — Escape | 21:49 |
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| 17. | Nyaasu / DieNyaa | 701 | Let's Play Professor Layton und die Schatulle der Pandora [Part 11] | 1:03:11 |
| 18. | GamingMagic13 | 530 | Professor Layton and the Diabolical Box - Finale | Chapter Seven | 42:55 |
| 19. | Jeroro | 465 | LP Professeur Layton et la boite de Pandore Ep.1 Prologue | 26:39 |
| 20. | NintenDaanNC | 400 | [NC US] Real People Plays Professor Layton Video 1 | 1:20 |
| 21. |  Gaming Jay | 366 | Professor Layton and the Diabolical Box (Nintendo DS) - Let's Play 1001 Games - Episode 648 | 1:14:07 |
| 22. |  Gamer UA | 294 | Professor Layton Pandora's Box HD port gameplay on Sony PS Vita Slim Playstation Vita 3.65 Henkaku | 10:54 |
| 23. | NikoDunkel | 264 | DIE WAHRHEIT: SCHATULLE DER PANDORA | Let's Play Professor Layton und die Schatulle der Pandora #21 | 52:41 |
| 24. | illustuff | 195 | El profesor Layton y la caja de Pandora || NDS || Playthrough - Part 06 [Spanish/Castellano] | 2:31:03 |
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| 26. | Bmaster4114 | 145 | Let's Play Professor Layton and the Diabolical Box: We are Running for our Lives! Finale | 3:22:09 |
| 27. | PokeSantiTW | 122 | Let's Play: El Profesor Layton y La Caja de Pandora - PARTE 3 - Tom, el niño perdido | 24:24 |
| 28. | pizze fritte | 113 | Professor Layton and the Diabolical Box HD: Playthrough - Prologue | 21:38 |
| 29. | Aryashadeslay VA | 91 | The Culprit Revealed?!: Professor Layton and the Diabolical Box (Streamed February 1st, 2024) | 2:28:26 |
| 30. | Tykirou | 81 | Professor Layton and Pandora's Box (2009) | NDS | Full Playthrough - Part 7 | 5:41:26 |
| 31. | Britanouille | 80 | PR. LAYTON ET LA BOÎTE DE PANDORE Ep.16 - Un final émouvant :'( - Let's Play FR | 1:25:13 |
| 32. | Quentibus | 79 | LPQuentibus - Professeur Layton et la boîte de Pandore #12 [FINAL] | 56:17 |
| 33. | HexTree | 73 | Professor Layton and the Diabolical Box - Blind Let's Play - part 8 (finale) | 1:16:39 |
| 34. | Icestar | 69 | Professor Layton & Pandora Box (Diabolical Box) Let's Play #17 - Potential Vampire!?? | 14:16 |
| 35. | Void Ink | 37 | Museum - Professor Layton and the Diabolical Box 100% Playthrough |19| Void Ink Plays | 31:34 |
| 36. | Mil'ceryse | 28 | (Rediff) Let's Play Professeur Layton et la boîte de Pandore (7) : La fin du jeu !? | 51:42 |
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| 38. | InstaSim | 9 | Professor Layton and the Pandora's Box Part 26 - THE CULPRIT UNCOVERED | 26:13 |
| 39. | skatemancory222 | 8 | Professor Layton & the Diabolical Box Casual Playthrough [Part 3 - FINALE] | 5:31:56 |
| 40. | Pudding Muffin | 6 | Professor Layton and the Diabolical Box [10] The Culprit, Revealed | 34:38 |
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