| 1. | Tykirou | 1:16:36:40 | Professor Layton and Pandora's Box (2009) | NDS | Full Playthrough - Part 7 | 5:41:26 |
| 2. | TRASHTAZMANI | 1:01:28:11 | PROFESSOR LAYTON und die Schatulle der Pandora • #62 - Geschafft! | Let's Play | 31:12 |
| 3. |  Bmaster4114 | 1:00:34:17 | Let's Play Professor Layton and the Diabolical Box: We are Running for our Lives! Finale | 3:22:09 |
| 4. |  TwilightShiek | 21:39:23 | Let's Play Professor Layton und die Schatulle der Pandora [German/100%] #83 [Bonus/Final] | 16:09 |
| 5. |  illustuff | 20:19:24 | El profesor Layton y la caja de Pandora || NDS || Playthrough - Part 06 [Spanish/Castellano] | 2:31:03 |
| 6. |  Britanouille | 19:31:26 | PR. LAYTON ET LA BOÎTE DE PANDORE Ep.16 - Un final émouvant :'( - Let's Play FR | 1:25:13 |
| 7. | Matrik On Stage | 17:27:47 | Let's Play Professor Layton & the Diabolical Box #46 -Finale! [Blind] | 42:43 |
| 8. | NRWBoy18 | 17:24:32 | Lets Play Together - Prof. Layton und die Schatulle der Pandora [Bonus-Teil 1] | 14:00 |
| 9. |  skatemancory222 | 17:13:29 | Professor Layton & the Diabolical Box Casual Playthrough [Part 3 - FINALE] | 5:31:56 |
| 10. |  HexTree | 16:34:13 | Professor Layton and the Diabolical Box - Blind Let's Play - part 8 (finale) | 1:16:39 |
| 11. | ChallengeTime | 16:30:10 | Let's Play Professor Layton und die Schatulle der Pandora (Part 49 / ENDE): Diabolische Box! | 54:16 |
| 12. | NikoDunkel | 14:11:14 | DIE WAHRHEIT: SCHATULLE DER PANDORA | Let's Play Professor Layton und die Schatulle der Pandora #21 | 52:41 |
| 13. | DjDraculea | 13:47:02 | Let's Play Professor Layton und die Schatulle der Pandora #070 | 11:09 |
| 14. | Nyaasu / DieNyaa | 11:50:51 | Let's Play Professor Layton und die Schatulle der Pandora [Part 11] | 1:03:11 |
| 15. |  Raxby | 9:43:23 | Professor Layton and Pandora's Box — Part 27 — Escape | 21:49 |
| 16. | Mil'ceryse | 9:42:30 | (Rediff) Let's Play Professeur Layton et la boîte de Pandore (7) : La fin du jeu !? | 51:42 |
| 17. | Quentibus | 9:06:46 | LPQuentibus - Professeur Layton et la boîte de Pandore #12 [FINAL] | 56:17 |
| 18. | Linkonito TV | 9:00:41 | Let's Play Professeur Layton et la boite de pandore (DS) #2 | 9:00:41 |
| 19. | HellfirePlaythroughs | 8:55:17 | Professor Layton and the Diabolical Box playthrough [Part 59] | 6:47 |
| 20. |  fluojn | 8:34:17 | Let's Play eli pelataan: Professor Layton and Pandora's Box osa 9 FINAALI | 56:10 |
| 21. | Maestro_2099 les VOD | 3:32:54 | Let's play: Professeur Layton et la boîte de Pandore #1 | 3:32:54 |
| 22. | Icestar | 3:29:32 | Professor Layton & Pandora Box (Diabolical Box) Let's Play #17 - Potential Vampire!?? | 14:16 |
| 23. | Void Ink | 2:41:34 | Museum - Professor Layton and the Diabolical Box 100% Playthrough |19| Void Ink Plays | 31:34 |
| 24. | Aryashadeslay VA | 2:28:26 | The Culprit Revealed?!: Professor Layton and the Diabolical Box (Streamed February 1st, 2024) | 2:28:26 |
| 25. | RanguGamer | 1:58:09 | LP Layton y La Caja de Pandora 10 Atrapados Juntos | 48:55 |
| 26. | TheMcBlob | 1:29:01 | Let's Play Professor Layton und die Schatulle der Pandora (Part 20) - dummer Köter - | 14:44 |
| 27. | Ferim | 1:24:04 | Professeur Layton et la Boîte de Pandore | Episode 10 [FIN] : L'enfant cachée | Let's Play | 53:25 |
| 28. | Suraht | 1:21:07 | Let's Play Professor Layton and the Diabolical Box - Part 50 | 27:21 |
| 29. | PokeSantiTW | 1:14:59 | Let's Play: El Profesor Layton y La Caja de Pandora - PARTE 3 - Tom, el niño perdido | 24:24 |
| 30. | Gaming Jay | 1:14:07 | Professor Layton and the Diabolical Box (Nintendo DS) - Let's Play 1001 Games - Episode 648 | 1:14:07 |
| 31. | GamingMagic13 | 42:55 | Professor Layton and the Diabolical Box - Finale | Chapter Seven | 42:55 |
| 32. | El canal de Gavi | 35:52 | Lets Play "Profesor Layton y la Caja de Pandora" Ep.1 | 35:52 |
| 33. | Pudding Muffin | 34:38 | Professor Layton and the Diabolical Box [10] The Culprit, Revealed | 34:38 |
| 34. | Save Data | 29:45 | BEST OF Professor Layton and the Diabolical Box with an Actual Professor! Save Data Team | 29:45 |
| 35. | Jeroro | 26:39 | LP Professeur Layton et la boite de Pandore Ep.1 Prologue | 26:39 |
| 36. | InstaSim | 26:13 | Professor Layton and the Pandora's Box Part 26 - THE CULPRIT UNCOVERED | 26:13 |
| 37. | HellfireComms | 25:54 | Professor Layton and Pandora's Box playthrough [Part 1: The Elysian Box] | 25:54 |
| 38. | SoulHunter96 | 23:47 | Help! I need somebody! | Professor Layton und die Schatulle der Pandora | Folge 029 [Stream] | 23:47 |
| 39. | pizze fritte | 21:38 | Professor Layton and the Diabolical Box HD: Playthrough - Prologue | 21:38 |
| 40. | ItsmeJamesAJ | 15:04 | Let's Play Professor Layton and the Diabolical Box - Part 1 - Smells Fishy... | 15:04 |
| 41. |  Gamer UA | 10:54 | Professor Layton Pandora's Box HD port gameplay on Sony PS Vita Slim Playstation Vita 3.65 Henkaku | 10:54 |
| 42. | NintenDaanNC | 1:20 | [NC US] Real People Plays Professor Layton Video 1 | 1:20 |
