| 1. |  TetraNinja | Prototype Walkthrough - Part 1 Prologue Rampage Let's Play PS3 XBOX PC (Gameplay / Commentary) | 2,312,011 | Walkthrough |
| 2. | TetraNinja | Prototype 2 Walkthrough - Part 1 Opening & the Mercer Virus PS3 XBOX PC (P2 Gameplay/Commentary) | 902,933 | Walkthrough |
| 3. | TetraNinja | Prototype 2 Walkthrough - Part 2 The Strong Survive PS3 XBOX PC (P2 Gameplay / Commentary) | 371,915 | Walkthrough |
| 4. | TetraNinja | Prototype 2 Walkthrough - Part 3 Claw Powers PS3 XBOX PC (P2 Gameplay / Commentary) | 307,754 | Walkthrough |
| 5. | TetraNinja | Prototype Walkthrough - Part 40 Series Finale ENDING Let's Play PS3 XBOX PC | 302,005 | Walkthrough |
| 6. | TetraNinja | Prototype 2 Walkthrough - Part 4 Operation Flytrap PS3 XBOX PC (P2 Gameplay / Commentary) | 241,391 | Walkthrough |
| 7. | SpeirsTheAmazingHD | Prototype 2 - UNLIMITED POWER | 206,495 | |
| 8. | TetraNinja | Prototype 2 Walkthrough - Part 5 Brain Drain PS3 XBOX PC (P2 Gameplay / Commentary) | 206,164 | Walkthrough |
| 9. | TetraNinja | Prototype 2 Walkthrough - Part 6 Tendril Powers PS3 XBOX PC (P2 Gameplay / Commentary) | 177,059 | Walkthrough |
| 10. | TetraNinja | Prototype 2 Walkthrough - Part 7 Shield Powers PS3 XBOX PC (P2 Gameplay / Commentary) | 151,212 | Walkthrough |
| 11. | TetraNinja | Prototype 2 Walkthrough - Part 50 Murder Your Maker ENDING (P2 Gameplay / Commentary) | 148,908 | Walkthrough |
| 12. | DJParsons89 | Prototype 2 - Episode 16 - Excessive Force DLC Pack | 142,842 | |
| 13. | TetraNinja | Prototype Walkthrough - Part 20 Helicopter Let's Play PS3 XBOX PC | 140,057 | Walkthrough |
| 14. | TetraNinja | Prototype 2 Walkthrough - Part 8 Blacknet Trials PS3 XBOX PC (P2 Gameplay / Commentary) | 135,628 | Walkthrough |
| 15. | TetraNinja | Prototype 2 Walkthrough - Part 20 Blade Power PS3 XBOX PC (P2 Gameplay / Commentary) | 133,685 | Walkthrough |
| 16. | TetraNinja | Prototype Walkthrough - Part 15 Liar Liar Let's Play PS3 XBOX PC | 124,308 | Walkthrough |
| 17. | TetraNinja | Prototype 2 Walkthrough - Part 9 Infected Salvage PS3 XBOX PC (P2 Gameplay / Commentary) | 118,615 | Walkthrough |
| 18. | TetraNinja | Prototype Walkthrough - Part 14 Lure McMullen Let's Play PS3 XBOX PC | 114,878 | Walkthrough |
| 19. | TetraNinja | Prototype 2 Walkthrough - Part 10 Supression PS3 XBOX PC (P2 Gameplay / Commentary) | 113,572 | Walkthrough |
| 20. | TetraNinja | Prototype 2 Walkthrough - Part 49 Heller's Request PS3 XBOX PC (P2 Gameplay / Commentary) | 101,772 | Walkthrough |
| 21. | TetraNinja | Prototype Walkthrough - Part 35 Boss Elizabeth Greene Let's Play PS3 XBOX PC | 101,669 | Walkthrough |
| 22. | TetraNinja | Prototype 2 Walkthrough - Part 12 Super Soldiers PS3 XBOX PC (P2 Gameplay / Commentary) | 101,227 | Walkthrough |
| 23. | TetraNinja | Prototype Walkthrough - Part 19 Penn Station Corpses Let's Play PS3 XBOX PC | 100,944 | Walkthrough |
| 24. | TetraNinja | Prototype 2 Walkthrough - Part 11 The Lab Rat PS3 XBOX PC (P2 Gameplay / Commentary) | 98,883 | Walkthrough |
| 25. | TetraNinja | Prototype Walkthrough - Part 18 Cancer Let's Play PS3 XBOX PC | 98,790 | Walkthrough |
| 26. | TetraNinja | Prototype Walkthrough - Part 22 Hunter Chase Let's Play PS3 XBOX PC | 91,578 | Walkthrough |
| 27. | TetraNinja | Prototype 2 Walkthrough - Part 16 The Airbridge PS3 XBOX PC (P2 Gameplay / Commentary) | 91,232 | Walkthrough |
| 28. | TetraNinja | Prototype 2 Walkthrough - Part 18 Sabrina Galloway PS3 XBOX PC (P2 Gameplay / Commentary) | 90,762 | Walkthrough |
| 29. | TetraNinja | Prototype 2 Walkthrough - Part 15 Natural Selection PS3 XBOX PC (P2 Gameplay / Commentary) | 89,874 | Walkthrough |
| 30. | TetraNinja | Prototype 2 Walkthrough - Part 13 RADNET Trials PS3 XBOX PC (P2 Gameplay / Commentary) | 89,865 | Walkthrough |
| 31. | TetraNinja | Prototype 2 Walkthrough - Part 14 Orion Phase Two PS3 XBOX PC (P2 Gameplay / Commentary) | 88,707 | Walkthrough |
| 32. | TetraNinja | Prototype 2 Walkthrough - Part 21 Evolved Thief PS3 XBOX PC (P2 Gameplay / Commentary) | 88,520 | Walkthrough |
| 33. | TetraNinja | Prototype 2 Walkthrough - Part 17 Mutagen PS3 XBOX PC (P2 Gameplay / Commentary) | 88,094 | Walkthrough |
| 34. | TetraNinja | Prototype 2 Walkthrough - Part 19 A Nest of Vipers PS3 XBOX PC (P2 Gameplay / Commentary) | 85,924 | Walkthrough |
| 35. | TetraNinja | Prototype Walkthrough - Part 26 Infected Vision Let's Play PS3 XBOX PC | 84,152 | Walkthrough |
| 36. | TetraNinja | Prototype Walkthrough - Part 30 Last Army Base Let's Play PS3 XBOX PC | 79,930 | Walkthrough |
| 37. | TetraNinja | Prototype Walkthrough - Part 37 Bloodtox Filters Let's Play PS3 XBOX PC | 79,273 | Walkthrough |
| 38. | TetraNinja | Prototype 2 Walkthrough - Part 30 Brawler Pack Power PS3 XBOX PC (P2 Gameplay / Commentary) | 77,808 | Walkthrough |
| 39. | TetraNinja | Prototype Walkthrough - Part 29 Men Like Gods Let's Play PS3 XBOX PC | 76,728 | Walkthrough |
| 40. | TetraNinja | Prototype 2 Walkthrough - Part 22 Runaway Brawlers PS3 XBOX PC (P2 Gameplay / Commentary) | 76,689 | Walkthrough |
| 41. | TheGamerMan | [Prototype 2] HD - Bio-Bomb Power | 76,630 | |
| 42. | TetraNinja | Prototype Walkthrough - Part 27 Thermobaric Tank Let's Play PS3 XBOX PC | 75,998 | Walkthrough |
| 43. | TetraNinja | Prototype Walkthrough - Part 28 Supreme Hunter Let's Play PS3 XBOX PC | 74,936 | Walkthrough |
| 44. | SpeirsTheAmazingHD | Prototype 2 - SUPER SNEAKY | 74,919 | |
| 45. | TheGamerMan | [Prototype 2] HD - Goliath Battle | 74,810 | |
| 46. | TetraNinja | Prototype 2 Walkthrough - Part 25 Many Upgrades PS3 XBOX PC (P2 Gameplay / Commentary) | 74,671 | Walkthrough |
| 47. | TetraNinja | Prototype 2 Walkthrough - Part 23 Taking the Castle PS3 XBOX PC (P2 Gameplay / Commentary) | 74,019 | Walkthrough |
| 48. | TetraNinja | Prototype Walkthrough - Part 25 Hunter Trap Let's Play PS3 XBOX PC | 73,254 | Walkthrough |
| 49. | TetraNinja | Prototype 2 Walkthrough - Part 43 Agent Griffin PS3 XBOX PC (P2 Gameplay / Commentary) | 71,924 | Walkthrough |
| 50. | TetraNinja | Prototype Walkthrough - Part 24 Overkill Let's Play PS3 XBOX PC | 71,168 | Walkthrough |
| 51. | TheGamerMan | [Prototype 2] HD - Pack Leader Power | 69,461 | |
| 52. | TetraNinja | Prototype 2 Walkthrough - Part 24 Infected Hive PS3 XBOX PC (P2 Gameplay / Commentary) | 67,384 | Walkthrough |
| 53. | TetraNinja | Prototype 2 Walkthrough - Part 31 Athena Revealed PS3 XBOX PC (P2 Gameplay / Commentary) | 67,367 | Walkthrough |
| 54. | TetraNinja | Prototype Walkthrough - Part 31 Mysterious Contact Let's Play PS3 XBOX PC | 67,073 | Walkthrough |
| 55. | TetraNinja | Prototype 2 Walkthrough - Part 32 Lair Troubles PS3 XBOX PC (P2 Gameplay / Commentary) | 65,336 | Walkthrough |
| 56. | TetraNinja | Prototype 2 Walkthrough - Part 29 Alpha Wolf PS3 XBOX PC (P2 Gameplay / Commentary) | 64,319 | Walkthrough |
| 57. | TetraNinja | Prototype 2 Walkthrough - Part 27 Yellow Zone PS3 XBOX PC (P2 Gameplay / Commentary) | 64,302 | Walkthrough |
| 58. | TetraNinja | Prototype 2 Walkthrough - Part 26 Stronghold PS3 XBOX PC (P2 Gameplay / Commentary) | 63,771 | Walkthrough |
| 59. | TetraNinja | Prototype Walkthrough - Part 34 Helicopter Escort Let's Play PS3 XBOX PC | 63,303 | Walkthrough |
| 60. | TetraNinja | Prototype 2 Walkthrough - Part 28 A Maze of Blood PS3 XBOX PC (P2 Gameplay / Commentary) | 63,035 | Walkthrough |
| 61. | TetraNinja | Prototype 2 Walkthrough - Part 33 Burned from Memory PS3 XBOX PC (P2 Gameplay / Commentary) | 60,503 | Walkthrough |
| 62. | VGS - Video Game Sophistry | Prototype 2- James Heller Hates Computers | 57,876 | |
| 63. | TetraNinja | Prototype 2 Walkthrough - Part 34 Pasty Hacker PS3 XBOX PC (P2 Gameplay / Commentary) | 56,206 | Walkthrough |
| 64. | TetraNinja | Prototype 2 Walkthrough - Part 40 Meeting w/ Sabrina PS3 XBOX PC (P2 Gameplay / Commentary) | 55,717 | Walkthrough |
| 65. | TetraNinja | Prototype 2 Walkthrough - Part 42 Goliath PS3 XBOX PC (P2 Gameplay / Commentary) | 54,821 | Walkthrough |
| 66. | TetraNinja | Prototype 2 Walkthrough - Part 35 Whitelight Facility PS3 XBOX PC (P2 Gameplay / Commentary) | 54,352 | Walkthrough |
| 67. | TetraNinja | Prototype 2 Walkthrough - Part 45 PS3 XBOX PC (P2 Gameplay / Commentary) | 54,132 | Walkthrough |
| 68. | TetraNinja | Prototype 2 Walkthrough - Part 48 Lost in the System PS3 XBOX PC (P2 Gameplay / Commentary) | 53,448 | Walkthrough |
| 69. | TetraNinja | Prototype 2 Walkthrough - Part 36 Gentek Support PS3 XBOX PC (P2 Gameplay / Commentary) | 53,337 | Walkthrough |
| 70. | TetraNinja | Prototype 2 Walkthrough - Part 41 Last Resort PS3 XBOX PC (P2 Gameplay / Commentary) | 52,624 | Walkthrough |
| 71. | TetraNinja | Prototype 2 Walkthrough - Part 44 Stronghold PS3 XBOX PC (P2 Gameplay / Commentary) | 52,076 | Walkthrough |
| 72. | TetraNinja | Prototype 2 Walkthrough - Part 37 Collectables Only PS3 XBOX PC (P2 Gameplay / Commentary) | 51,294 | Walkthrough |
| 73. | TetraNinja | Prototype 2 Unboxing - RADNET Limited Edition Online Pass Explanation and RAGE! PS3 XBOX PC | 49,501 | Walkthrough |
| 74. | TheGamerMan | [Prototype 2] HD - Devastator Power | 48,403 | |
| 75. | TetraNinja | Prototype 2 Walkthrough - Part 47 Operation Firehawk PS3 XBOX PC (P2 Gameplay / Commentary) | 47,789 | Walkthrough |
| 76. | TetraNinja | Prototype 2 Walkthrough - Part 38 Collectables Only PS3 XBOX PC (P2 Gameplay / Commentary) | 44,825 | Walkthrough |
| 77. | TetraNinja | Prototype 2 Walkthrough - Part 39 Collectables Only PS3 XBOX PC (P2 Gameplay / Commentary) | 43,798 | Walkthrough |
| 78. | TetraNinja | Prototype 2 Walkthrough - Part 46 PS3 XBOX PC (P2 Gameplay / Commentary) | 43,781 | Walkthrough |
| 79. | koukoupuffs | Prototype - Water is your friend! | 41,281 | |
| 80. | Matt McMuscles | One step forward, two steps back! - Prototype 2 | 41,037 | |
| 81. | TheGamerMan | [Prototype 2] HD - Hammerfist Power | 40,853 | |
| 82. | NerdyNetty | Prototype 2 Review | 25,940 | Review |
| 83. | Skill Games | Prototype 2 Walkthrough Part 1 PS3 | 25,500 | Walkthrough |
| 84. | HappyConsoleGamer | RADICAL ENTERTAINMENT CLOSES! - Happy Console Gamer | 24,420 | |
| 85. | TheGamerMan | [Prototype 2] HD - Whipfist Power | 21,273 | |
| 86. | TheGamerMan | [Prototype 2] HD - Blade Power | 16,358 | |
| 87. | DJParsons89 | Prototype 2 - Episode 17 - Lindin Park Collectables | 16,328 | |
| 88. | DJParsons89 | Prototype 2 - Episode 15 - Colossal Mayhem DLC Pack | 14,792 | |
| 89. | GOLDTOOTH | Creative Film & VFX Studio | Prototype 2 - Yellow Zone Trailer | 14,449 | Preview |
| 90. | DanQ8000 | Prototype 2 - Walkthrough [HD] - Part 1 | DanQ8000 | 12,191 | Walkthrough |
| 91. | TetraNinja | Prototype 2 Walkthrough - Prologue & Storyline Re-cap of Original Game | 11,273 | Walkthrough |
| 92. | VGS - Video Game Sophistry | Prototype 2 BlackBox Guide. Yellow Zone. Linden Park | 10,025 | Guide |
| 93. | DJParsons89 | Prototype 2 - Episode 18 | 9,527 | |
| 94. | DanQ8000 | Prototype 2 - Walkthrough [HD] - Part 46 (Ending) | DanQ8000 | 9,147 | Walkthrough |
| 95. | Kevin | Prototype 2 Walkthrough Part 10 - Super Tentacle Hentai Porn | 9,143 | Walkthrough |
| 96. | DanQ8000 | Game Unboxing - Prototype 2 - Blackwatch Collector's Edition | 8,414 | |
| 97. | DJParsons89 | Prototype 2 - Episode 19 | 8,217 | |
| 98. | DanQ8000 | Prototype 2 - Walkthrough [HD] - Part 2 | DanQ8000 | 8,096 | Walkthrough |
| 99. | DanQ8000 | Prototype 2 - Walkthrough [HD] - Part 3 | DanQ8000 | 6,822 | Walkthrough |
| 100. | DanQ8000 | Prototype 2 - Walkthrough [HD] - Part 4 | DanQ8000 | 6,732 | Walkthrough |
