| 1. |  Kratosworld | Prototype 2 - Pelicula completa en Español - PC Ultra [1080p 60fps] | 812,264 | |
| 2. | alexelcapo | DIRECTO 1 || PROTOTYPE #alexelmonstruo | 266,431 | |
| 3. | ChamoGutiérrez | Virus MERCER - BLACKLIGHT: Explicación biológica de PROTOTYPE | 166,333 | |
| 4. | alexelcapo | DIRECTO 2 || PROTOTYPE #alexelmonstruo | 128,844 | |
| 5. | Bartolo | Prototype 2 | Walkthrough | El comienzo | Parte 1 | 123,078 | Walkthrough |
| 6. | alexelcapo | DIRECTO 4 Y FINAL || PROTOTYPE #alexelmonstruo | 113,212 | |
| 7. | Norber Salvador | [PROTOTYPE 2] REMASTERED #1 | UN NUEVO PROTOTYPO FUNCIONAL | Gameplay Español | 94,623 | |
| 8. | Bartolo | Prototype 2 | Walkthrough | Consumiendo al DR.Shaffeld | Parte 4 | 93,325 | Walkthrough |
| 9. | Bartolo | Prototype 2 | Walkthrough | Final Boss | Parte 19 | 88,483 | Walkthrough |
| 10. | Bartolo | Prototype 2 | Walkthrough | La huida | Parte 2 | 85,692 | Walkthrough |
| 11. | alexelcapo | DIRECTO 3 || PROTOTYPE #alexelmonstruo | 84,863 | |
| 12. | 3DJuegos | Prototype 2 - Vídeo Análisis 3DJuegos | 72,220 | |
| 13. | Bartolo | Prototype 2 | Walkthrough | ¡Mis garras lo parten! | Parte 3 | 62,866 | Walkthrough |
| 14. | JairovY | Prototype 2 | GamePlay HD | Español | Parte 1| TheJairovY | 56,948 | |
| 15. | xNaet | Final de Prototype 2 En Español HD Batalla Final | 54,524 | |
| 16. | bacostick | Prototype 2 - Juego completo en Español | Sin comentarios | Longplay | 53,908 | |
| 17. | Bartolo | Prototype 2 - Prototype 2 | Walkthrough | ¡Mis tentáculos molan! | Parte 5 | 46,710 | Walkthrough |
| 18. | Wolfen | FIX lag en prototype 2 y usar modo ventana | 46,542 | |
| 19. | Bartolo | Prototype 2 | Walkthrough | Bombas biologicas | Parte 12 | 37,374 | Walkthrough |
| 20. | Bartolo | Prototype 2 | Walkthrough | La muerte de Roland | Parte 10 | 35,531 | Walkthrough |
| 21. | Bartolo | Prototype 2 | Walkthrough | Orion fase 2 | Parte 8 | 35,090 | Walkthrough |
| 22. | Bartolo | Prototype 2 | Walkthrough | Matando DR.Koenig | Parte 9 | 30,998 | Walkthrough |
| 23. | Bartolo | Prototype 2 | Walkthrough | Batalla épica y el agente Griffin | Parte 16 | 30,584 | Walkthrough |
| 24. | Bartolo | Prototype 2 | Walkthrough | Protege al padre Guerra | Parte 6 | 30,273 | Walkthrough |
| 25. | Bartolo | Prototype 2 | Walkthrough | ¡Traición! | Parte 7 | 30,133 | Walkthrough |
| 26. | Bartolo | Prototype 2 | Walkthrough | Buscando a Amaya | Parte 18 | 28,333 | Walkthrough |
| 27. | Bartolo | Prototype 2 | Walkthrough | La muerte de Gallagher | Parte 11 | 27,556 | Walkthrough |
| 28. | Bartolo | Prototype 2 | Walkthrough | Pilotando helicopteros | Parte 14 | 27,116 | Walkthrough |
| 29. | Bartolo | Prototype 2 | Walkthrough | Último recurso | Parte 15 | 26,763 | Walkthrough |
| 30. | Bartolo | Prototype 2 | Walkthrough | La muerte de la DRa.Archer | Parte 13 | 25,584 | Walkthrough |
| 31. | Bartolo | Prototype 2 | Walkthrough | ¡Me han descubierto! | Parte 17 | 25,196 | Walkthrough |
| 32. | JairovY | Prototype 2 GamePlay HD Español Parte 2 TheJairovY | 23,899 | |
| 33. | Sergiopatin99 | Prototype 2 | Parte 1 - Modo historia | Soy un dios [Español] | 20,276 | |
| 34. | Migueltrix | Como utilizar la habilidad de caza en Prototype 2 | 19,743 | |
| 35. | xNaet | HE MATADO A JUSTIN BIEBER | 14,254 | |
| 36. | JairovY | Prototype 2 GamePlay HD Español Parte 3 TheJairovY | 13,701 | |
| 37. | Norber Salvador | [PROTOTYPE 2] REMASTERED #2 | CAOS EN ZONA SEGURA | Gameplay Español | 13,129 | |
| 38. | xNaet | Prototype 2 - Consejos Del Juego - Cosas Molonas ! - NaetGamer | 12,737 | |
| 39. | Hobby Consolas | Prototype 2 (HD) Análisis en HobbyNews.es | 11,504 | |
| 40. | Sergiopatin99 | Prototype 2 | Parte 11 - FINAL - Modo historia | Combate contra Alex Mercer [Español] | 10,335 | |
| 41. | MeriStation | Prototype 2, Vídeo Análisis | 9,717 | |
| 42. | JairovY | Prototype 2 GamePlay HD Español Parte 4 TheJairovY | 8,740 | |
| 43. | Sensession | Prototype 2 review HD | 8,735 | Review |
| 44. | Norber Salvador | [PROTOTYPE 2] REMASTERED #3 | MEJORADO | Gameplay Español | 7,577 | |
| 45. | Javier Casariego (Raggnarokh) | [LongPlay] Prototype 2 (Español) Parte 1/10 | 7,146 | |
| 46. | Sergiopatin99 | Prototype 2 | Parte 2 - Modo historia | Padre Luis Guerra [Español] | 6,995 | |
| 47. | JairovY | Prototype 2 GamePlay HD Español Parte 6 TheJairovY | 6,795 | |
| 48. | Norber Salvador | [PROTOTYPE 2] REMASTERED #4 | EL PLAN DE MERCER | Gameplay Español | 6,154 | |
| 49. | PlayStation España | Prototype 2 - Habilidades de James | 5,609 | |
| 50. | Oxabar25 | Prototype 2 - Gameplay on very low PC | 5,205 | |
| 51. | JairovY | Prototype 2 GamePlay HD Español Parte 5 TheJairovY | 5,073 | |
| 52. | Pianthesia | Outlaws Chase [Prototype 2] - Roblox Deadrails | 4,999 | |
| 53. | Testingame | Prototype 2 (Ultra Settings) | GTX 960 + i5 4690 [1080p 60fps] | 4,883 | |
| 54. | JoseliyoHD | Prototype 2 | Guia Trofeo | Icaro y Por encima de todo | 4,760 | |
| 55. | Norber Salvador | [PROTOTYPE 2] REMASTERED #5 | UNA ESPERANZA EMERGENTE | Gameplay Español | 4,744 | |
| 56. | Sergiopatin99 | Prototype 2 | Parte 3 - Modo historia | Batalla contra Hidra [Español] | 4,630 | |
| 57. | Norber Salvador | [PROTOTYPE 2] HACIENDO SECUNDARIAS,COLECCIONABLES Y CONSIGUIENDO TRAJE DE ALEX MERCER | EN DIRECTO | 4,355 | |
| 58. | JairovY | Prototype 2 GamePlay HD Español Parte 7 TheJairovY | 3,995 | |
| 59. | JairovY | Prototype 2 GamePlay HD Español Parte 8 TheJairovY | 3,977 | |
| 60. | JairovY | Prototype 2 GamePlay HD Español Parte 19 Final Del Juego TheJairovY | 3,812 | |
| 61. | JairovY | Prototype 2 GamePlay HD Español Parte 9 TheJairovY | 3,720 | |
| 62. | MaxiElSecundario | Prototype 2 | Walkthrough | FINAL | Alex Mercer vs James Heller | 3,712 | Walkthrough |
| 63. | Norber Salvador | [PROTOTYPE 2] REMASTERED *FINAL | A PRUEBA DE EXTINCION | Gameplay Español | 3,661 | |
| 64. | JoseliyoHD | Prototype 2 | Guia Trofeo | Todos Juntos | 3,507 | |
| 65. | Sergiopatin99 | Prototype Parte 17 - Protege el tanque termobárico | 3,418 | |
| 66. | Sergiopatin99 | Prototype 2 | Parte 4 - Modo historia | El proyecto Orion [Español] | 3,361 | |
| 67. | JairovY | Prototype 2 GamePlay HD Español Parte 10 TheJairovY | 3,352 | |
| 68. | Fnac España | Prototype 2 - Tráiler DLC Flesh Cleaver Exclusivo Fnac | 3,253 | |
| 69. | uVeJuegos | Prototype 2 - Skin Alex Mercer [Español] [720p] | 3,199 | |
| 70. | PlayStation España | Prototype 2 - Habilidades de lucha | 3,101 | |
| 71. | thegungnirgames | Prototype 2 HD - Parte 1 | 3,059 | |
| 72. | JoseliyoHD | Prototype 2 | Guia Trofeo | Fuera de juego | 2,862 | |
| 73. | Sergiopatin99 | Prototype 2 | Parte 5 - Modo historia | La zona verde [Español] | 2,734 | |
| 74. | Akihabara Blues | [AKB] Prototype 2 - Daddy Home Intro [Español] | 2,658 | |
| 75. | JairovY | Prototype 2 GamePlay HD Español Parte 11 TheJairovY | 2,653 | |
| 76. | Sergiopatin99 | Prototype 2 | Parte 9 - Modo historia | Puño de látigo [Español] | 2,646 | |
| 77. | PlayStation España | Tráiler Prototype 2 - Imagen real | 2,612 | |
| 78. | XINOT | Eso sí que fue una protopapeada #youtubeshorts #prototype #humor | 2,586 | |
| 79. | Sergiopatin99 | Prototype 2 | Parte 6 - Modo historia | Lucha contra el Juggernaut [Español] | 2,562 | |
| 80. | JairovY | Prototype 2 GamePlay HD Español Parte 12 TheJairovY | 2,420 | |
| 81. | JairovY | Prototype 2 GamePlay HD Español Parte 14 TheJairovY | 2,242 | |
| 82. | JairovY | Prototype 2 GamePlay HD Español Parte 18 TheJairovY | 2,241 | |
| 83. | JairovY | Prototype 2 GamePlay HD Español Parte 13 TheJairovY | 2,233 | |
| 84. | thegungnirgames | Prototype 2 HD - Parte 2 | 2,148 | |
| 85. | Hobby Consolas | Prototype 2 Gameplay (HD) Entrevista en HobbyNews.es | 2,129 | |
| 86. | JoseliyoHD | Prototype 2 | Guia Trofeo | Furia al volante | 2,126 | |
| 87. | Wolfen | Prototype 2 lag fix (Version mini) | 2,066 | |
| 88. | JoseliyoHD | Prototype 2 | Guia Trofeo | El suelo es lava | 2,039 | |
| 89. | Sergiopatin99 | Prototype 2 | Parte 7 - Modo historia | La doctora Archer [Español] | 1,984 | |
| 90. | thegungnirgames | Prototype 2 HD - Parte 25 | 1,980 | |
| 91. | Javier Casariego (Raggnarokh) | [LongPlay] Prototype 2 (Español) Parte 2/10 | 1,971 | |
| 92. | JairovY | Prototype 2 GamePlay HD Español Parte 15 TheJairovY | 1,942 | |
| 93. | JairovY | Prototype 2 GamePlay HD Español Parte 16 TheJairovY | 1,914 | |
| 94. | MeriStation | Prototype 2, Vídeo Guía: Operación ratonera | 1,865 | |
| 95. | MadnessCT 2.0 | PROTOTYPE 2 GAMEPLAY ESPAÑOL #1 SOMOS JAMES HELLER | 1,855 | |
| 96. | Dekuwa | Prototype 2 - Tanques | 1,824 | |
| 97. | Sergiopatin99 | Prototype 2 | Parte 8 - Modo historia | Limpiando la ciudad de la infeccion [Español] | 1,804 | |
| 98. | thegungnirgames | Prototype 2 HD - Parte 3 | 1,763 | |
| 99. | JairovY | Prototype 2 GamePlay HD Español Parte 17 TheJairovY | 1,741 | |
| 100. | thegungnirgames | Prototype 2 HD - Parte 4 | 1,633 | |
