| 1. |  Gamesweasel | 85,041 | Play Prototype 2 online | 0:30 |
| 2. | WatsonKHD | 68,153 | PROTOTYPE 2's Platinum Trophy was HELL-ER Fun | 43:15 |
| 3. | Elanip | 37,439 | Let's Play Prototype 2 - Walkthrough - Final Boss Defeat Alex Mercer (Ending Cutscene - End of Game) | 14:04 |
| 4. | Dat Mental Gamer | 29,524 | [PROTOTYPE 2] | New Armor and Alpha/Beta Boss Alex (Model Swap Mods) | 13:09 |
| 5. | TRW | 10,631 | Prototype 2 Playthrough | Part 55 [FINAL] | 10:24 |
| 6. | samdaman118 | 6,041 | Prototype 2 Lets Play Commentary Part 19 (FINAL BOSS FIGHT) | 43:27 |
| 7. | IFreeMz | 5,923 | Prototype 2 Gameplay Walkthrough Part 19 - Alpha Wolf - Let's Play Review | 15:29 |
| 8. | PlayStation Access | 4,471 | PlayStation Access TV 30 - Prototype 2! Max Payne 3! Gadgets! | 10:55 |
| 9. | Alpaka Whacker | 2,509 | Alpaka Plays "Prototype 2" - Episode 10 : Violently Ripping Orion Apart | 11:25 |
| 10. | ExcaliburTF93 | 787 | Prototype 2 Playthrough Part 69 | 9:29 |
| 11. | Guides For Gamers | 653 | Prototype 2 - Let's Play #1: 0 - 25% Completion | 2:40:24 |
| 12. | Know Your Games | 416 | [Prototype 2] # 22 - Last Resort | 25:57 |
| 13. | Annoyingcybergaming | 271 | Prototype 2 : Prototype Recap [HD] [720] [3D] | 1:56 |
| 14. | JohnTMorton | 170 | Nostalgamer Unboxes Prototype 2 Two On Sony Playstation 3 Three UK PAL System Version | 2:19 |
| 15. | Mackay81 TV | 112 | Kicking infected so hard they explode💥then surfing bodies 😎 | 0:39 |
| 16. | Electric Skeleton | 104 | Prototype 2 Playthrough (Part 6 - FINALE) - 52 Games 52 Weeks | 1:13:17 |
| 17. | The Real OAF | 90 | Let's Play - Prototype 2 (Part 8 + Final) [PC] | 1:00:04 |
| 18. | ScottishFeller | 62 | Prototype 2 | Playthrough #31 | Murder Your Maker | 9:28 |
| 19. | Not So Serious Gaming | 58 | Infected Man Has The Power Of The Gods | 2:15:26 |
| 20. | TheLooneyFocker | 21 | [PROTOTYPE®2] Alpha Wolf | 9:30 |
| 21. | supercheatscom | 10 | 18 Pack Leader - Alpha Wolf | 5:09 |
| 22. | LordMegaWin Gaming | 6 | Prototype 2 PC Playthrough | 7:47:25 |
| 23. | Andy Skullz | 0 | [PROTOTYPE®2: HELPING DANA | 1:00:01 |
