| 1. |  Global Gaming | PROTOTYPE 2 - GOD MODE max upgrades (all abilities + skins) | 5,977,454 | |
| 2. | Whitelight | PROTOTYPE 2: 7 Years Later | 684,657 | Review |
| 3. | You Mashub | prototype Vs prototype 2 | Comparison - part.1 | 320,508 | |
| 4. | Rock Paper Shotgun | Prototype 2 live action trailer - Johnny Cash's Hurt | 279,424 | |
| 5. | OfficialDadCubed | Dad³ Plays... Prototype 2 | 227,939 | |
| 6. | TRGVC | Prototype 2 - Hunt and Consume Dr Samuel Billingsley - Gameplay Part 3. (HD) | 194,484 | |
| 7. | Moby | Prototype 2 Walkthrough - Part 1 [Intro] Let's Play XBOX PS3 PC | 123,732 | Walkthrough |
| 8. | Lomadiah | YogTrailers - Prototype 2 E3 Trailer | 111,414 | Preview |
| 9. | VE3TRO | Prototype 2 Weapons Trailer (HD 720p) | 94,792 | Preview |
| 10. | Gamesweasel | Play Prototype 2 online | 85,041 | Let's Play |
| 11. | IFreeMz | Prototype 2 Gameplay Walkthrough Part 1 Infected - Let's Play Review | 82,461 | Walkthrough |
| 12. | VE3TRO | E3 2011: Prototype 2 Action Trailer (HD 720p) | 79,146 | Preview |
| 13. | Moby | Prototype 2 Walkthrough - Part 2 Let's Play XBOX PS3 PC | 72,790 | Walkthrough |
| 14. | WatsonKHD | PROTOTYPE 2's Platinum Trophy was HELL-ER Fun | 68,153 | Let's Play |
| 15. | Poundy94 | Prototype 2 Heller Fully Upgraded | 67,555 | |
| 16. | GameSprout | Games Are Weird - Episode 56 | 62,579 | Show |
| 17. | KomputerKa Plus | Prototype 2 داستان بازی | 52,889 | |
| 18. | Moby | Prototype 2 Walkthrough - ENDING Murder Your Maker Let's Play XBOX PS3 PC | 45,074 | Walkthrough |
| 19. | Moby | Prototype 2 Walkthrough - Part 27 Let's Play XBOX PS3 PC | 44,393 | Walkthrough |
| 20. | Moby | Prototype 2 Walkthrough - Part 25 Let's Play XBOX PS3 PC | 43,803 | Walkthrough |
| 21. | Moby | Prototype 2 Walkthrough - Part 26 Let's Play XBOX PS3 PC | 42,613 | Walkthrough |
| 22. | Man Forged In Steel | Prototype 2 Xbox One Gameplay | 39,841 | |
| 23. | StaticXPlayStation | [PROTOTYPE®] - How to get Infinite Health | 34,662 | |
| 24. | Evanz111 | The Funniest Scene in Prototype 2 | 32,809 | |
| 25. | Archivist42 | Top 5 Most Powerful Game Characters | 31,690 | |
| 26. | IFreeMz | Prototype 2 Walkthrough Part 2 - Operation Flytrap - Let's Play Review | 31,237 | Walkthrough |
| 27. | Global Gaming | Prototype 2【ALL BOSSES】& Ending | 31,154 | Walkthrough |
| 28. | Moby | Prototype 2 Walkthrough - Part 3 Let's Play XBOX PS3 PC | 31,084 | Walkthrough |
| 29. | Evanz111 | All Prototype 2 Vehicle Finishers! | 27,485 | |
| 30. | Evanz111 | Prototype in 2 Minutes! | 26,596 | |
| 31. | Moby | Prototype 2 Walkthrough - Part 20 Let's Play XBOX PS3 PC | 26,211 | Walkthrough |
| 32. | GAME | Prototype 2 - "Homecoming" Trailer | 25,556 | Preview |
| 33. | IFreeMz | Prototype 2 Walkthrough Part 3 - Orion's Belt - Let's Play Review | 25,199 | Walkthrough |
| 34. | Evanz111 | Epic Prototype 2 Montage! | 24,348 | |
| 35. | TheLooneyFocker | [PROTOTYPE®2] James Heller Vs Alex Mercer (Hard) | 24,244 | |
| 36. | Moby | Prototype 2 Walkthrough - Part 33 Let's Play XBOX PS3 PC | 23,712 | Walkthrough |
| 37. | Moby | Prototype 2 Walkthrough - Part 32 Let's Play XBOX PS3 PC | 23,304 | Walkthrough |
| 38. | Moby | Prototype 2 Walkthrough - Part 4 Let's Play XBOX PS3 PC | 23,151 | Walkthrough |
| 39. | Moby | Prototype 2 Walkthrough - Part 30 Let's Play XBOX PS3 PC | 23,138 | Walkthrough |
| 40. | Moby | Prototype 2 Walkthrough - Part 31 Let's Play XBOX PS3 PC | 22,921 | Walkthrough |
| 41. | Moby | Prototype 2 Walkthrough - Part 19 Let's Play XBOX PS3 PC | 22,052 | Walkthrough |
| 42. | Moby | Prototype 2 Walkthrough - Part 18 Let's Play XBOX PS3 PC | 20,853 | Walkthrough |
| 43. | Moby | Prototype 2 Walkthrough - Part 34 Let's Play XBOX PS3 PC | 20,492 | Walkthrough |
| 44. | Moby | Prototype 2 Walkthrough - Part 5 Let's Play XBOX PS3 PC | 20,471 | Walkthrough |
| 45. | VE3TRO | Prototype 2 Whip and Hammer Video (HD 720p) | 20,202 | |
| 46. | Khyzer Group | PROTOTYPE 2 - The Red Zone | 19,538 | |
| 47. | Moby | Prototype 2 Walkthrough - Part 22 Let's Play XBOX PS3 PC | 19,053 | Walkthrough |
| 48. | Moby | Prototype 2 Walkthrough - Part 6 Let's Play XBOX PS3 PC | 18,468 | Walkthrough |
| 49. | Moby | Prototype 2 Walkthrough - Part 21 Let's Play XBOX PS3 PC | 18,243 | Walkthrough |
| 50. | IFreeMz | Prototype 2 Walkthrough Part 4 - Brain Drain - Let's Play Review | 18,135 | Walkthrough |
| 51. | VE3TRO | Prototype 2 Walkthrough Part 1 (HD 720p) | 17,690 | Walkthrough |
| 52. | Moby | Prototype 2 Walkthrough - Part 23 Let's Play XBOX PS3 PC | 17,298 | Walkthrough |
| 53. | Dat Mental Gamer | [PROTOTYPE] | Playable Elizabeth Greene (Model Swap) | 16,917 | |
| 54. | Moby | Prototype 2 Walkthrough - Part 29 Let's Play XBOX PS3 PC | 16,661 | Walkthrough |
| 55. | Moby | Prototype 2 Walkthrough - Part 24 Let's Play XBOX PS3 PC | 16,535 | Walkthrough |
| 56. | You Mashub | Venom & Carnage Prototype 2 _ Mod | 15,841 | |
| 57. | You Mashub | How do you do the dash to down in Prototype 2 tutorial _ DLc require | 15,701 | Tutorial |
| 58. | Moby | Prototype 2 Walkthrough - Part 16 Let's Play XBOX PS3 PC | 15,591 | Walkthrough |
| 59. | Dat Mental Gamer | [PROTOTYPE 2] | Real Boss Alex Mercer (Model Swap Mod) | 15,513 | |
| 60. | Sparkles | PROTOTYPE 2 By fAiss | 15,304 | |
| 61. | Moby | Prototype 2 Walkthrough - Part 28 Let's Play XBOX PS3 PC | 14,986 | Walkthrough |
| 62. | Moby | Prototype 2 Walkthrough - Part 17 Let's Play XBOX PS3 PC | 14,006 | Walkthrough |
| 63. | Evanz111 | Funniest Mission in Prototype 2! | 13,704 | |
| 64. | Dat Mental Gamer | [PROTOTYPE 2] | Alpha Alex Mercer Mod - Free Roam Combat | 13,575 | Let's Play |
| 65. | VE3TRO | Prototype 2 - Heller Throws Down Trailer (HD 720p) | 13,349 | Preview |
| 66. | IFreeMz | Prototype 2 Walkthrough Part 5 - Project Long Shadow - Let's Play Review | 13,179 | Walkthrough |
| 67. | Dat Mental Gamer | [PROTOTYPE 2] | James Heller Vs. Alex Mercer - But You Play As Alex (Model Swap Mods) | 13,108 | |
| 68. | VE3TRO | Prototype 2 Timeline Trailer (HD 720p) | 12,971 | Preview |
| 69. | Dat Mental Gamer | HOW TO INSTALL SCRIPT MODS FOR [PROTOTYPE] | 12,766 | Guide |
| 70. | IFreeMz | Prototype 2 Walkthrough Part 6 - The Lab Rat - Let's Play Review | 12,136 | Walkthrough |
| 71. | Khanlusa | How To Save Alex Mercer - (The Story Board) | 11,934 | |
| 72. | IFreeMz | Prototype 2 Walkthrough Part 7 - Feeding Time - Let's Play Review | 11,561 | Walkthrough |
| 73. | Moby | Prototype 2 Walkthrough - Part 9 Let's Play XBOX PS3 PC | 11,338 | Walkthrough |
| 74. | DiaMorph Live | Prototype 2 - Заключительная Серия [Против своего создателя] | 11,197 | |
| 75. | IFreeMz | Prototype 2 Walkthrough Part 8 - Salvation - Let's Play Review | 10,064 | Walkthrough |
| 76. | Moby | Prototype 2 Walkthrough - Part 13 Let's Play XBOX PS3 PC | 10,036 | Walkthrough |
| 77. | FearlessFlourish | Prototype 2 - All Growed Up Achievement - Fearless GT | 10,017 | |
| 78. | Moby | Prototype 2 Walkthrough - Part 14 Let's Play XBOX PS3 PC | 9,905 | Walkthrough |
| 79. | Full Playthroughs | Prototype 2 | Gameplay Walkthrough - FULL GAME | PS5 4K HD | No Commentary | 9,801 | Walkthrough |
| 80. | VE3TRO | Prototype 2 Walkthrough Part 2 (HD 720p) | 9,760 | Walkthrough |
| 81. | Dat Mental Gamer | [PROTOTYPE 2] | HD Alex Mercer Mod! | 9,720 | |
| 82. | Moby | Prototype 2 Walkthrough - Part 8 Let's Play XBOX PS3 PC | 9,480 | Walkthrough |
| 83. | Moby | Prototype 2 Walkthrough - Part 11 Let's Play XBOX PS3 PC | 9,350 | Walkthrough |
| 84. | Moby | Prototype 2 Walkthrough - Part 10 Let's Play XBOX PS3 PC | 9,317 | Walkthrough |
| 85. | Moby | Prototype 2 Walkthrough - Part 15 Let's Play XBOX PS3 PC | 9,302 | Walkthrough |
| 86. | Moby | Prototype 2 Walkthrough - Part 12 Let's Play XBOX PS3 PC | 9,264 | Walkthrough |
| 87. | You Mashub | Prototype 2 All Skins And Weapons & ultimate abilities | 9,224 | |
| 88. | IFreeMz | Prototype 2 Walkthrough Part 10 - Orion Phase 2 - Let's Play Review | 9,223 | Walkthrough |
| 89. | IFreeMz | Prototype 2 Walkthrough Part 9 - The Mad Scientist - Let's Play Review | 9,121 | Walkthrough |
| 90. | IFreeMz | Prototype 2 Gameplay Walkthrough Part 16 - Taking The Castle - Let's Play Review | 8,979 | Walkthrough |
| 91. | Moby | Prototype 2 Walkthrough - Part 7 Let's Play XBOX PS3 PC | 8,847 | Walkthrough |
| 92. | VE3TRO | Prototype 2 Walkthrough Part 3 (HD 720p) | 8,698 | Walkthrough |
| 93. | Fact Fiend Gaming - With Karl Smallwood | Karl & Lucas play Prototype - Part 2 - Body-jacking the military is the best kind of stealth | 8,621 | |
| 94. | Elanip | Let's Play Prototype 2 - Walkthrough - See HUGE Infected Monster and Get Infected by Alex Mercer | 8,569 | Let's Play |
| 95. | IFreeMz | Prototype 2 Gameplay Walkthrough Part 12 - The Air Bridge - Let's Play Review | 8,435 | Walkthrough |
| 96. | IFreeMz | Prototype 2 Gameplay Walkthrough Part 11 - Natural Selection - Let's Play Review | 8,227 | Walkthrough |
| 97. | Dat Mental Gamer | [PROTOTYPE 2] | More Accurate Alex Mercer Mod - Prototype 1 Style (MADE BY ME) | 8,209 | |
| 98. | IFreeMz | Prototype 2 GameplayWalkthrough Part 15 - The White Light - Let's Play Review | 8,079 | Walkthrough |
| 99. | OTG | [S1][P2] Prototype [HTSF] | 7,887 | |
| 100. | Global Gaming | Prototype 2【FULL GAME】walkthrough | Longplay | 7,781 | Walkthrough |
