| 1. |  Gamesweasel | Play Prototype 2 online | 85,041 | Let's Play |
| 2. | WatsonKHD | PROTOTYPE 2's Platinum Trophy was HELL-ER Fun | 68,153 | Let's Play |
| 3. | Dat Mental Gamer | [PROTOTYPE 2] | Alpha Alex Mercer Mod - Free Roam Combat | 13,575 | Let's Play |
| 4. | Elanip | Let's Play Prototype 2 - Walkthrough - See HUGE Infected Monster and Get Infected by Alex Mercer | 8,569 | Let's Play |
| 5. | Dat Mental Gamer | [PROTOTYPE 2] | Alpha Alex Mercer (First Variant) | 7,743 | Let's Play |
| 6. | Elanip | Let's Play Prototype 2 - Walkthrough - Unlocked a New Attack Awesome Black Hole | 6,036 | Let's Play |
| 7. | IFreeMz | Prototype 2 Gameplay Walkthrough Part 19 - Alpha Wolf - Let's Play Review | 5,923 | Let's Play |
| 8. | Dat Mental Gamer | [PROTOTYPE 2] | New Armor and Alpha/Beta Boss Alex (Model Swap Mods) | 5,364 | Let's Play |
| 9. | Elanip | Let's Play Prototype 2 - Walkthrough - Final Boss Defeat Alex Mercer (Ending Cutscene - End of Game) | 5,147 | Let's Play |
| 10. | PlayStation Access | PlayStation Access TV 30 - Prototype 2! Max Payne 3! Gadgets! | 4,471 | Let's Play |
| 11. | Elanip | Let's Play Prototype 2 - Walkthrough - Learning The Ropes of Consuming People | 3,384 | Let's Play |
| 12. | Elanip | Let's Play Prototype 2 - Walkthrough - Escape Blackwatch Testing and We're Working with Alex Mercer? | 2,856 | Let's Play |
| 13. | Dat Mental Gamer | [PROTOTYPE 2] | Alpha Alex Mercer (Second Variant) | 2,842 | Let's Play |
| 14. | Elanip | Let's Play Prototype 2 - Walkthrough - Side Mission Consuming Like a Ninja | 1,869 | Let's Play |
| 15. | Elanip | Let's Play Prototype 2 - Walkthrough - Blackwatch Missions (A.K.A Side Missions) | 1,693 | Let's Play |
| 16. | Elanip | Let's Play Prototype 2 - Walkthrough - VERY BIG GAME TWIST | 1,693 | Let's Play |
| 17. | samdaman118 | Prototype 2 Lets Play Commentary Part 1 | 1,518 | Let's Play |
| 18. | Elanip | Let's Play Prototype 2 - Walkthrough - ROOKS Helped Me Find My Daughter?!?!? | 1,483 | Let's Play |
| 19. | TRW | Prototype 2 Playthrough | Part 1 | 1,359 | Let's Play |
| 20. | samdaman118 | Prototype 2 Lets Play Commentary Part 19 (FINAL BOSS FIGHT) | 1,340 | Let's Play |
| 21. | Elanip | Let's Play Prototype 2 - Walkthrough - Blackwatch Missions are Finished! Finally | 1,148 | Let's Play |
| 22. | Elanip | Let's Play Prototype 2 - Walkthrough - Backstabbed by The Doctor | 1,118 | Let's Play |
| 23. | Elanip | Let's Play Prototype 2 - Walkthrough - He Know my Secret | 1,022 | Let's Play |
| 24. | Elanip | Let's Play Prototype 2 - Walkthrough - Lair Domination | 963 | Let's Play |
| 25. | TRW | Prototype 2 Playthrough | Part 2 | 682 | Let's Play |
| 26. | Guides For Gamers | Prototype 2 - Let's Play #1: 0 - 25% Completion | 653 | Let's Play |
| 27. | samdaman118 | Prototype 2 Lets Play Commentary Part 3 | 473 | Let's Play |
| 28. | samdaman118 | Prototype 2 Lets Play Commentary Part 2 | 468 | Let's Play |
| 29. | Elanip | Let's Play Prototype 2 - Walkthrough - GET TO THE CCHHHHHOOOOOPPPPPAAAAA | 458 | Let's Play |
| 30. | TRW | Prototype 2 Playthrough | Part 55 [FINAL] | 407 | Let's Play |
| 31. | Alpaka Whacker | Alpaka Plays "Prototype 2" - Episode 1 : Becoming A Monster | 384 | Let's Play |
| 32. | Alpaka Whacker | Alpaka Plays "Prototype 2" - Episode 2 : Consume, Throw, Destroy | 368 | Let's Play |
| 33. | Alpaka Whacker | Alpaka Plays "Prototype 2" - Episode 4 : Training Your Heller to Evolve with Rare Candy | 358 | Let's Play |
| 34. | Alpaka Whacker | Alpaka Plays "Prototype 2" - Episode 6 : Bigger Claws and Tendrils | 351 | Let's Play |
| 35. | TRW | Prototype 2 Playthrough | Part 54 | 322 | Let's Play |
| 36. | TRW | Prototype 2 Playthrough | Part 3 | 317 | Let's Play |
| 37. | Alpaka Whacker | Alpaka Plays "Prototype 2" - Episode 3 : Brawler Battle Bonanza | 306 | Let's Play |
| 38. | samdaman118 | Prototype 2 Lets Play Commentary Part 18 | 305 | Let's Play |
| 39. | Annoyingcybergaming | Prototype 2 : Prototype Recap [HD] [720] [3D] | 271 | Let's Play |
| 40. | samdaman118 | Prototype 2 Lets Play Commentary Part 4 | 265 | Let's Play |
| 41. | TRW | Prototype 2 Playthrough | Part 4 | 239 | Let's Play |
| 42. | TRW | Prototype 2 Playthrough | Part 21 | 239 | Let's Play |
| 43. | Know Your Games | [Prototype 2] # 22 - Last Resort | 238 | Let's Play |
| 44. | TRW | Prototype 2 Playthrough | Part 5 | 224 | Let's Play |
| 45. | TRW | Prototype 2 Playthrough | Part 8 | 214 | Let's Play |
| 46. | TRW | Prototype 2 Playthrough | Part 42 | 213 | Let's Play |
| 47. | TRW | Prototype 2 Playthrough | Part 40 | 209 | Let's Play |
| 48. | Alpaka Whacker | Alpaka Plays "Prototype 2" - Episode 5 : People Are Delicious | 207 | Let's Play |
| 49. | TRW | Prototype 2 Playthrough | Part 17 | 202 | Let's Play |
| 50. | samdaman118 | Prototype 2 Lets Play Commentary Part 5 | 202 | Let's Play |
| 51. | TRW | Prototype 2 Playthrough | Part 10 | 195 | Let's Play |
| 52. | TRW | Prototype 2 Playthrough | Part 7 | 195 | Let's Play |
| 53. | Alpaka Whacker | Alpaka Plays "Prototype 2" - Episode 7 : There Is No Escape From Me | 186 | Let's Play |
| 54. | TRW | Prototype 2 Playthrough | Part 52 | 184 | Let's Play |
| 55. | Know Your Games | [Prototype 2] # 18 - Alpha Wolf | 178 | Let's Play |
| 56. | TRW | Prototype 2 Playthrough | Part 34 | 175 | Let's Play |
| 57. | TRW | Prototype 2 Playthrough | Part 6 | 173 | Let's Play |
| 58. | JohnTMorton | Nostalgamer Unboxes Prototype 2 Two On Sony Playstation 3 Three UK PAL System Version | 170 | Let's Play |
| 59. | TRW | Prototype 2 Playthrough | Part 15 | 166 | Let's Play |
| 60. | TRW | Prototype 2 Playthrough | Part 13 | 163 | Let's Play |
| 61. | TRW | Prototype 2 Playthrough | Part 43 | 160 | Let's Play |
| 62. | TRW | Prototype 2 Playthrough | Part 9 | 159 | Let's Play |
| 63. | TRW | Prototype 2 Playthrough | Part 11 | 158 | Let's Play |
| 64. | samdaman118 | Prototype 2 Lets Play Commentary Part 16 | 157 | Let's Play |
| 65. | TRW | Prototype 2 Playthrough | Part 20 | 156 | Let's Play |
| 66. | TRW | Prototype 2 Playthrough | Part 41 | 154 | Let's Play |
| 67. | Alpaka Whacker | Alpaka Plays "Prototype 2" - Episode 10 : Violently Ripping Orion Apart | 153 | Let's Play |
| 68. | TRW | Prototype 2 Playthrough | Part 51 | 152 | Let's Play |
| 69. | TRW | Prototype 2 Playthrough | Part 46 | 151 | Let's Play |
| 70. | samdaman118 | Prototype 2 Lets Play Commentary Part 17 | 151 | Let's Play |
| 71. | TRW | Prototype 2 Playthrough | Part 18 | 149 | Let's Play |
| 72. | TRW | Prototype 2 Playthrough | Part 22 | 148 | Let's Play |
| 73. | samdaman118 | Prototype 2 Lets Play Commentary Part 7 | 147 | Let's Play |
| 74. | TRW | Prototype 2 Playthrough | Part 24 | 147 | Let's Play |
| 75. | TRW | Prototype 2 Playthrough | Part 50 | 144 | Let's Play |
| 76. | TRW | Prototype 2 Playthrough | Part 12 | 143 | Let's Play |
| 77. | TRW | Prototype 2 Playthrough | Part 53 | 142 | Let's Play |
| 78. | TRW | Prototype 2 Playthrough | Part 48 | 141 | Let's Play |
| 79. | TRW | Prototype 2 Playthrough | Part 39 | 140 | Let's Play |
| 80. | samdaman118 | Prototype 2 Lets Play Commentary Part 10 | 140 | Let's Play |
| 81. | TRW | Prototype 2 Playthrough | Part 25 | 139 | Let's Play |
| 82. | samdaman118 | Prototype 2 Lets Play Commentary Part 6 | 136 | Let's Play |
| 83. | TRW | Prototype 2 Playthrough | Part 37 | 135 | Let's Play |
| 84. | TRW | Prototype 2 Playthrough | Part 23 | 133 | Let's Play |
| 85. | TRW | Prototype 2 Playthrough | Part 30 | 133 | Let's Play |
| 86. | samdaman118 | Prototype 2 Lets Play Commentary Part 13 | 133 | Let's Play |
| 87. | TRW | Prototype 2 Playthrough | Part 38 | 132 | Let's Play |
| 88. | TRW | Prototype 2 Playthrough | Part 19 | 132 | Let's Play |
| 89. | TRW | Prototype 2 Playthrough | Part 14 | 129 | Let's Play |
| 90. | TRW | Prototype 2 Playthrough | Part 33 | 128 | Let's Play |
| 91. | samdaman118 | Prototype 2 Lets Play Commentary Part 11 | 127 | Let's Play |
| 92. | TRW | Prototype 2 Playthrough | Part 31 | 126 | Let's Play |
| 93. | TRW | Prototype 2 Playthrough | Part 16 | 125 | Let's Play |
| 94. | TRW | Prototype 2 Playthrough | Part 29 | 125 | Let's Play |
| 95. | TRW | Prototype 2 Playthrough | Part 27 | 124 | Let's Play |
| 96. | TRW | Prototype 2 Playthrough | Part 32 | 121 | Let's Play |
| 97. | TRW | Prototype 2 Playthrough | Part 26 | 119 | Let's Play |
| 98. | TRW | Prototype 2 Playthrough | Part 44 | 115 | Let's Play |
| 99. | Alpaka Whacker | Alpaka Plays "Prototype 2" - Episode 8 : Church Defense Cause Im Awesome | 115 | Let's Play |
| 100. | samdaman118 | Prototype 2 Lets Play Commentary Part 8 | 110 | Let's Play |
