| 301. | The Smoking Skull | 60,923 | (FINAL) [Prototype 2] New Game+ on Insane! - Part 8 [No Commentary] | 50:56 |
| 302. |  Proyah | 60,911 | Prototype 2 PC Gameplay - Maximum Settings [GTX580 Intel Core i7 2600K] | 16:31 |
| 303. | FiveGamesBR | 60,576 | Prototype 2: Colossal Mayhem DLC Pack Trailer [HD] | 2:11 |
| 304. |  Elanip | 60,487 | Let's Play Prototype 2 - Walkthrough - Final Boss Defeat Alex Mercer (Ending Cutscene - End of Game) | 14:04 |
| 305. | 0'20 Magazine | 60,375 | Prototype 2: DLC Pack "Colossal Mayhem" | 1:53 |
| 306. |  Kevin | 60,222 | Prototype 2 Walkthrough Part 46 - FINALE | 30:06 |
| 307. |  rechyyy | 59,056 | Prototype 2 - PC Gameplay - Max Settings | 2:54 |
| 308. |  BEGINPLAY | 58,765 | [รีวิว] Prototype 2 (รีวิวเกมเก่า) | 19:25 |
| 309. |  RabidRetrospectGames | 58,321 | Prototype 2 - Murder Your Maker (Alex Mercer Boss Fight) - Ending | 5:58 |
| 310. |  3GordosB | 58,037 | Reseña Prototype 2 | 3 Gordos Bastardos | 13:01 |
| 311. | Skill Games | 57,948 | Prototype 2 Ending Walkthrough Part 21 PS3 | 16:12 |
| 312. |  Zulin`s v-log | 57,337 | Zulin`s v-log: Prototype 2 (02.08.2012) 2/2 | 1:10:46 |
| 313. |  Ben SAK | 57,108 | PROTOTYPE 2 HATIRLADIĞINIZ GİBİ Mİ? | 0:00 |
| 314. | Duxativa | 56,262 | Prototype 2 Parte 3 y Ultima | 14:23 |
| 315. |  SpottinGames | 56,246 | [Prototype 2] Gameplay Walkthrough HD - Ending - Part 49 | 26:14 |
| 316. | RavenWits | 55,891 | Sıcağı Sıcağına: PROTOTYPE 2 | 32:12 |
| 317. | Snow_DoggCZ | 55,846 | Prototype 2 CZ-Denis Wayne+ Dr. Soren Donell | 11:36 |
| 318. |  Zoner Nel Videogioco | 55,647 | 10 giochi in cui TU SEI IL BOSS | 7:23 |
| 319. | Johnny Creek | 55,407 | Prototype 2 : Live Playthrough - Part 1 | 23:23 |
| 320. |  Zok | 55,113 | Τυχαρπασίες 4: Πρωτότυπη Παρακρατική Προβολή Προβάτων | 2:00 |
| 321. |  Voxel | 54,319 | [Videoanálise] Prototype 2 (PS3) - Baixaki Jogos | 5:29 |
| 322. |  bacostick | 53,908 | Prototype 2 - Juego completo en Español | Sin comentarios | Longplay | 6:12:34 |
| 323. | NinjaCakeAssassin | 53,814 | Παιχνιδοκριτική:Prototype 2 | 2:10 |
| 324. |  黑桐谷歌 | 53,699 | 黑桐谷歌【虐杀原形2】支线篇05 | 36:44 |
| 325. |  Gram.pl | 53,408 | Prototype 2 - trailer DLC Excessive Force | 1:53 |
| 326. | GamerrZOMBIE | 52,895 | PROTOTYPE 2 ENDING: LAST BOSS- FINAL Mission (Murder your maker) | 12:44 |
| 327. | KomputerKa Plus | 52,889 | Prototype 2 داستان بازی | 41:55 |
| 328. | mezar1k | 52,823 | Prototype 2 - MagicBox | 21:14 |
| 329. |  Mr Chaser | 52,282 | Прохождение Prototype 2 [Часть 23] Драка с Мерсером и Финал! | 29:55 |
| 330. | Kain Primus | 51,765 | Prototype 2 Walkthrough - Mission 31 - Murder your Maker | 13:36 |
| 331. | HipHopGamer | 51,447 | Prototype 2 " Welcome To NYZ " Live Performance By HipHopGamer " WE GO HARD " | 3:58 |
| 332. | KnightEdge22 | 50,862 | FIGHTING & STOPPING PROJECT ORION!!? [Prototype 2 #4] | 38:56 |
| 333. | TechUtopia | 50,576 | Exagear Prototype 2 I Dead Space I Gameplay PC Games on Android smartphone 2022 | 3:22 |
| 334. | Emabulator | 50,089 | Prototype 2 - Accolades Trailer | 1:28 |
| 335. | Zerozock | 50,079 | Let's Play Prototype 2 #41 German (Blind) [Baue] | 32:08 |
| 336. | Jonlaw | 50,037 | Prototype 2 Walkthrough: FINALE - Murder Your Maker (Gameplay/Commentary) XBOX | 21:25 |
| 337. | Wolfen | 49,048 | Prototype 2 lag fix (Version mini) | 3:08 |
| 338. | Rafael Medina | 48,626 | [PROTOTYPE2] - All Lairs Locations | 28:31 |
| 339. | HDGamerz | 47,717 | Prototype - Free Running Gameplay (HD) | 2:22 |
| 340. | Diaboliquin | 47,496 | Prototype - Devastator Attacks | 1:46 |
| 341. | XG247 | 46,835 | PREVIEW: Prototype 2, The start of James Heller's story. | 5:07 |
| 342. | SLP | 46,620 | Prototype 2 Entwickler-Tagebuch #1 | Bugs und Outtakes | 1:05 |
| 343. | Hantaa Archiwum | 46,436 | Prototype 2 - ep.16 - FINAL | 24:55 |
| 344. | นาย Tanisorn | 46,402 | เชื้อคิโมจิ | 6:43 |
| 345. | chaoticPERFECTION | 45,868 | Prototype 2 Glitches - Out of Map (Escape New York) [Voice Tutorial] | 6:18 |
| 346. | RedFlameFox | 45,805 | Un passante di Prototype 2 che sbrocca e rutta | 0:31 |
| 347. | Atender EXV (Remastered) | 45,763 | セインツロウは全員殺す ゴジラ級破壊神の美少女を解き放つ PROTOTYPE | 21:06 |
| 348. | Gameplayrj | 45,614 | Prototype 2 - Monstros! | 27:56 |
| 349. | Giant Bomb | 45,456 | Prototype 2's Colossal Mayhem DLC Appears to Live Up to its Title | 1:54 |
| 350. |  Cool Games | 45,279 | Фильм Прототип 2 [1080p/60 FPS] (Prototype 2 игрофильм) | 2:25:23 |
| 351. | Games Group | 44,067 | Где скачать игру Prototype 2 | 3:43 |
| 352. | CReaTe | 43,847 | Skibidi Toilet 55 ALL Secrets & Easter Eggs & some 56 Episode LEAKS! | 1:23 |
| 353. | hyagiz | 43,459 | Prototype 2: Gameplay Trailer HD QUALITY | 1:35 |
| 354. | italiangameschannel | 43,260 | Prototype ita Parte 3 | 8:16 |
| 355. | Maxwell Adams | 42,897 | Prototype 41 | 10:25 |
| 356. |  FreeCon | 42,873 | 프로토타입 2)Prototype 2 뻘연재 [51] | 11:01 |
| 357. |  San Mê Game | 41,634 | Prototype 2 - END - #9: Finish him ! | 19:35 |
| 358. | MizzyXGamer101 | 41,422 | Prototype 2 Remaster - Theater 40 | 25:56 |
| 359. | Filinov's Place | 41,315 | Prototype 2 - Обзор игры - Хороший плохой СИКВЕЛ | 24:54 |
| 360. | koukoupuffs | 41,281 | Prototype - Water is your friend! | 1:06 |
| 361. | Matt McMuscles | 41,037 | One step forward, two steps back! - Prototype 2 | 31:50 |
| 362. |  MrQuoty | 40,848 | Let's play Prototype 2 épisode 3 et 4 | 1:14:54 |
| 363. | Fact Fiend Gaming - With Karl Smallwood | 40,447 | Just put this guy on the American flag #shorts | 0:38 |
| 364. | OTG | 40,354 | [S1][P20] Prototype [HTSFL] | 10:01 |
| 365. | БУЛДЖАТь | 40,111 | Обзор PROTOTYPE 2 . БУЛДЖАТь | 7:29 |
| 366. | Man Forged In Steel | 39,841 | Prototype 2 Xbox One Gameplay | 23:47 |
| 367. | SnapCube 2 | 39,600 | The Game Gets Brave | [PROTOTYPE] - FINALE | 3:54:49 |
| 368. |  Mokka Commentry | 39,564 | Prototype 2 Full Game Story - Explained in Tamil (தமிழ்) | 14:24 |
| 369. | XGTV | 39,292 | Обзор Prototype 2 (Review) | 5:25 |
| 370. | Venus Flyy | 39,213 | How to hunt on Prototype 2 | 2:32 |
| 371. | AFGuidesHD | 39,135 | PROTOTYPE 2 - You're the bomb Trophy/Achievement guide [HD] | 0:51 |
| 372. | THE KUZ | 39,086 | KG [ Prototype ] #2 ไอ้ตูดใหญ่ !! | 10:39 |
| 373. | KL (arctic) | 39,062 | Subscriber Sunday - Prototype 2 (Campaign Walkthrough) | 3:44:27 |
| 374. | RajmanHDGaming | 38,998 | Prototype 'Mission Variety Walkthrough' TRUE-HD QUALITY | 4:42 |
| 375. | CommunityGame | 38,417 | Prototype 2 - Cutscenes Walkthrough Story Part 1 HD (Story Scene Opening Movie Intro) | 11:34 |
| 376. | SmartWorld Gaming | 37,938 | Prototype 2 - Video Recensione ITA by Games.it | 7:21 |
| 377. | GTAVIoclock | 37,565 | Prototype 2 gameplay interview | 3:42 |
| 378. | PSXN | 37,370 | Мнение о игре Prototype 2 | 3:53 |
| 379. |  Ben-Gun | 37,236 | Prototype 2 - "I Caught A Big One!" Trophy Guide | 0:46 |
| 380. |  *JesuSaleme* | 37,039 | De Humano a Prototipo | 1:00 |
| 381. | Brian Menard | 36,798 | PROTOTYPE 2 in 2024 First Impression Gameplay Part 4 | 2:28:28 |
| 382. | Game Informer | 36,739 | Prototype 2 Excessive Force DLC Trailer | 1:53 |
| 383. | Rando99 | 36,460 | PROTOTYPE 2: La secuela incomprendida | 0:00 |
| 384. | GeneralSecura | 36,403 | Let's Play Prototype #20 - Greene With Envy | 27:39 |
| 385. | BADNESS GAMER | 36,288 | BNG:Prototype2 #2 กรงเล็บวัวแดง | 19:22 |
| 386. | TTarantox | 36,258 | Prototype 2 Walkthrough w/TTarantox Part 28 [END] | 22:44 |
| 387. |  TheGameTeve | 36,235 | Prototype 2 Xbox 360 Videoteszt - GameTeVe.hu | 9:31 |
| 388. |  MK | 35,874 | PROTOTYPE 2 (PC) - Brutal Rampage & Epic Ragdoll Kills - 4K 60FPS | 0:00 |
| 389. | StaticXPlayStation | 35,711 | [PROTOTYPE®] - How to get Infinite Health | 1:36 |
| 390. | Fulito | 35,681 | PROTOTYPE 2 - FIN : HELLER VS MERCER | LET'S PLAY | 44:22 |
| 391. | Tulok the Barbrarian | 35,387 | How to Play Alex Mercer in Dungeons & Dragons (Prototype Build for D&D 5e) | 12:54 |
| 392. | Maximon Gaming | 35,314 | 【Prototype 2】Cốt Truyện Game | Đấng Cứu Thế Sa Đọa | 33:38 |
| 393. | WorldOfFacts | 35,002 | تاریخچه و داستان بازی پروتوتایپ | History of Prototype | 12:34 |
| 394. | Cyberith | 34,844 | Cyberith Virtualizer Prototype 2 gets tested on conventions. Priceless reactions | 2:46 |
| 395. | Th1FreeMan | 34,841 | Prototype 2 Free Roam HD 35min! | 35:54 |
| 396. | ZariumGamesTrailers | 34,798 | Prototype 2 - трейлер с живыми актерами The Power of Revenge | 1:31 |
| 397. | mul0 | 34,742 | Prototype 2 | Prototype 2 v1.0 | Prototype 2 : Trainer/Трейнер [v1.0][Enjoy][ETR] | 7:07 |
| 398. | Should You Play It? | 34,514 | What is the 3rd FREE MYSTERY GAME from EPIC? | 4:48 |
| 399. | Adonis Montage | 34,283 | Prototype 2: Mods And Skins | 33:22 |
| 400. | AskMyselfWhy | 34,137 | PROTOTYPE 2 - How to use Hunter Mode | 7:16 |
