| 1. |  Reaper | 333,238 | Quake 4 - Gameplay Playthrough Full Game (PC ULTRA 1080P 60FPS) No Commentary | 5:41:28 |
| 2. | Andrea Rovenski | 9,637 | Quake 4 (Sikkmod) Playthrough; Part 13 | 40:39 |
| 3. | ƒ r u 7 7 y | 8,468 | [4K EAX 5] Quake 4 \ SB X-Fi Hardware OpenAL 3D Sound | 51:33 |
| 4. | Lawrence Sonntag | 3,397 | Worst Spa Ever - Lawrence Plays Quake 4 Pt. 2 | 5:24:27 |
| 5. | RichterBelmont12 | 2,941 | Let's Play Quake 4 11: The Nexis Fight | 30:19 |
| 6. | Levan | 1,978 | Quake 4 - Gameplay Playthrough Full Game [2K:60FPS: Ray Tracing GI - Bright] Redux 🔴 | 5:20:42 |
| 7. | Murda1 | 1,545 | Quake 4 Multiplayer Online Gameplay Murda1 Belphegor vs Stywoo Rashan0121 (Game 2) | 15:53 |
| 8. | Virus BF | 1,321 | Sculpting STROGG from Quake 4 and VIRUS 1999 | 4:41 |
| 9. | LowBiasScarlet | 957 | Let's Play Quake IV-Episode 20: Mother Brain Quake Style | 27:09 |
| 10. | Cubeface | 824 | Quake 4 False Dawn playthrough | 1:23:51 |
| 11. | The Doomed Dog | 728 | Let's Play Quake 4 pt 24 Finale | 35:23 |
| 12. | JacksawJack | 724 | Let's Play Quake 4 (Part 15) | 19:19 |
| 13. | VGamingJunkieVT | 518 | Quake IV Let's Play [Finale] - Beating Them Like A Strogg | 38:21 |
| 14. | Raven800 | 211 | Raven800 Plays - Quake 4 ep.6 "The Strogg-hold" | 1:09:39 |
| 15. | StormChaser Z | 177 | Quake 4 Playthrough with Cheats! | 4:29:50 |
| 16. | AKA-Liam | 176 | [10] Lord British Plays Quake 4 Part 10 | 20:43 |
| 17. | TechHoller | 100 | Let's Play Quake 4 on PC - Start | 1:00:53 |
| 18. | Sc00pDaWh00p | 97 | Finally the big brain.. wow - Let's play - Quake 4 - Part 26 | 14:22 |
| 19. | GamerLeader | 59 | Quake 4 with Commentary Part 27-Helping Cortez out | 11:22 |
| 20. | Shadowsense Plays | 51 | ELEVATOR ACTION | Quake 4 #3 | 25:59 |
| 21. | WedgeBob the Survival_Panda | 50 | WedgeBob Plays Quake 4 Mission 31 Part 01 | 56:05 |
| 22. | Santo DeLobo | 33 | LETS PLAY SOME GUNZ!!! GunZ 2 The Second Duel -1- | 2:34 |
| 23. | Zygarde 22 | 31 | Let's Play Quake 4 Episode 1: Squib | 22:49 |
| 24. | Shotgun Chanel | 26 | Let's Play Прохождение Quake 4 часть 3 | 40:35 |
| 25. | rocksoldier97 | 11 | X360 Gaming! Episode 700: Quake 4 | 18:24 |
| 26. | Mad Matt | 9 | Matt Plays Quake #4 | 58:36 |
| 27. | Nuclear-Skull87 | 9 | Let's play Quake 4: Part 14 Nexus Core! | 39:00 |
| 28. | Goodnight Gamerz | 2 | Let's Play AtoZ - Quake 4 | 10:30 |
| 29. | Zach - The Gamer | 1 | Quake 4 (Redone) | Part 2: Welp, I'm moving fast... | 1:31:01 |
| 30. | RookiePro | 0 | Quake 4: One that plays - EPISODE 39 | 12:11 |
