| 2026-05-04 |  Shadow The Lion Queen | 9,090 | Serious Sam: The Second Encounter Walkthrough Level 13 Palenque Demon Final Part | 0:00 |
| 2025-01-24 | Ly203 Productions (Les Productions Ly203) | 39,800 | Serious Sam: The Second Encounter - Level/Niveau 12 | 0:00 |
| 2024-05-13 | FramePlay | 4,880 | Early Serious Sam HD Gameplay / July 14th, 2009 / Xbox 360 | 2:43 |
| 2024-02-29 | Masumi | 3,800 | [VOD] Serious Sam: The Second Encounter Part 2 | 4:21:28 |
| 2024-01-24 | The Silly Steve Show | 420 | Serious Sam: The Second Encounter - Part 2 | 13:53 |
| 2024-01-21 | Melneem | 27,900 | Serious Sam: The Second Encounter | СЕРЙОЗНИЙ СЕМ | ПРОХОДЖЕННЯ УКРАЇНСЬКОЮ | стріми українською | 6:29:53 |
| 2023-11-19 | Jon Renish | 1,060 | Steam Cleaning - Serious Sam Classic: The Second Encounter | 8:18 |
| 2023-10-08 | AilaChu Vods | 35 | Aila Plays Serious Sam - Final Boss | 4:25:49 |
| 2023-05-19 | Gianni Matragrano | 1,040,000 | I'M NOT GONNA SUGARCOAT IT. | 0:13 |
| 2023-05-09 | Klovac | 380 | Serious Sam The Second Encounter FULL GAME - Tourism Difficulty | 2:57:38 |
| 2023-01-28 | PanAnning | 872 | SERIOUS COOP - Session 4 | 1:26:20 |
| 2023-01-05 | Fiendzy | 1,420 | all aboard the serious train! | 2:12:07 |
| 2022-11-16 | Yuri the Wolfbat | 26 | Cornerian Cafe Episode 41 Serious Sam is Seriously Insane Part 5 | 22:01 |
| 2022-08-13 | Monument | 154 | Serious Sam Second Encounter (Fusion) - Grand Cathedral (NGH Community Night) | 26:13 |
| 2022-05-25 | BanAnERpH0N3 | 98 | Possibly A Short DLC Serious Sam Second Encounter LOTB DLC PS4 Part 1 Ending | 1:58:29 |
| 2022-04-03 | KHGhost | 2,140 | Serious Sam's World War 3 (Ending) | Serious Sam The Second Encounter HD Blind Playthrough | PS5 | 1:47:04 |
| 2022-01-11 | DigitalRossGamingStation | 1,880 | Serious Sam: The Second Encounter | Xbox Series X | Longplay | Co-op | Full Game Walkthrough | | 4:07:31 |
| 2021-12-09 | Gormo | 33 | Serious Sam: The Second Encounter, Teotihuacan - Serpent Yards skip | 1:19 |
| 2021-04-15 | The Detective on Twitch | 15 | Steam Backlog Series: Serious Sam - The Second Encounter | 10:25 |
| 2021-04-02 | Matthew Doucette (Xonatron) | 2,320 | Serious Sam HD: The Second Encounter (PC) - Episode: South America - Difficulty: Serious | 1:58:29 |
| 2020-10-09 | GameJade | 1,570 | Serious Sam - The Second Encounter: Serpent Yards Extended | 10:39 |
| 2020-07-28 | GamingTiger | 870 | SERIOUS SAM: The Second Encounter | Part 17 - END | GamePlay (2020) | WalkThrough on STADIA | HD | | 7:48 |
| 2020-05-13 | Retro Vibes | 4,650 | Unboxing Serious Sam: The Second Encounter by Gathering of Developers Platform : Windows XP, | 0:49 |
| 2020-05-08 | Neon Henchman | 251 | Vertical Hunt: Sérieux [Mod] Contient peut-être de la chasse à la verticale | 21:57 |
| 2019-05-30 | SugarCubeCris | 10,600 | Serious ASS !? Serious Sam The Second Encounter #5 | 21:48 |
| 2019-04-22 | No_Way301 | 131 | First Level - PrIm - Serious Sam: The Second Encounter HD - Xbox 360 | 25:41 |
| 2019-01-21 | Serious Sacor | 3,530 | Serious Sam Classic: The Second Encounter - Xbox Mod - Session 3 | 1:05:06 |
| 2019-01-09 | FrameRater | 122,000 | Best Way to Play Serious Sam Classics? | XBOX MOD (2019) | 12:19 |
| 2018-12-30 | Jaba Play | 358,000 | Serious Sam HD: Second Encounter - All Bosses | 15:00 |
| 2018-11-12 | One Doomed Game Critic | 866 | Serious Sam: The Second Encounter (HD) review - A serious successor | 8:21 |
| 2017-08-06 | JewelsVR | 4,450 | [VR] Serious Sam: The Second Encounter P1 | 2:33:06 |
| 2016-12-17 | HyruleChosenOne | 2,070 | Serious Sam TSE | 26:55 |
| 2015-04-17 | Simpelicity | 2,180 | Let's play Serious Sam SE [29] Lift off | 27:16 |
| 2013-12-14 | Anza TNT | 930 | Serious Sam HD - The 2nd Encounter With AwesomeMattG ep. 15 | 34:20 |
| 2012-02-08 | BSP | 2,760 | Serious Sam: The Second Encounter с Бонивуром и BSP (4) | 2:53:26 |
| 2011-05-11 | VTuber Zeromaster & Power Plays | 2,680 | Let's Fail Serious Sam Part 1 - I Srsly Suck | 20:32 |
