| 1. |  Serious Sacor | 3,592,383 | Serious Sam Classic: The Second Encounter - Xbox Mod - Session 3 | 1:05:06 |
| 2. | Gianni Matragrano | 377,306 | I'M NOT GONNA SUGARCOAT IT. | 0:13 |
| 3. | FrameRater | 38,304 | Best Way to Play Serious Sam Classics? | XBOX MOD (2019) | 12:19 |
| 4. | BSP | 23,650 | Serious Sam: The Second Encounter с Бонивуром и BSP (4) | 2:53:26 |
| 5. | Jaba Play | 5,047 | Serious Sam HD: Second Encounter - All Bosses | 15:00 |
| 6. | SugarCubeCris | 4,906 | Serious ASS !? Serious Sam The Second Encounter #5 | 21:48 |
| 7. | FramePlay | 3,679 | Early Serious Sam HD Gameplay / July 14th, 2009 / Xbox 360 | 2:43 |
| 8. | GameJade | 2,524 | Serious Sam - The Second Encounter: Serpent Yards Extended | 10:39 |
| 9. | Simpelicity | 2,169 | Let's play Serious Sam SE [29] Lift off | 27:16 |
| 10. | One Doomed Game Critic | 2,084 | Serious Sam: The Second Encounter (HD) review - A serious successor | 8:21 |
| 11. | LIMON | 1,737 | Проходим Зиккурат и Слоновий атриум в Serious Sam The Second Encounter | 1:07:03 |
| 12. | LY203 Productions (Les Productions LY203) | 1,727 | Serious Sam: The Second Encounter - Level/Niveau 12 | 0:00 |
| 13. | Fiendzy | 820 | all aboard the serious train! | 2:12:07 |
| 14. | Retro Canada | 721 | Unboxing Serious Sam: The Second Encounter by Gathering of Developers Platform : Windows XP, | 0:49 |
| 15. | KHGhost | 510 | Serious Sam's World War 3 (Ending) | Serious Sam The Second Encounter HD Blind Playthrough | PS5 | 1:47:04 |
| 16. | Melneem | 415 | Serious Sam: The Second Encounter | СЕРЙОЗНИЙ СЕМ | ПРОХОДЖЕННЯ УКРАЇНСЬКОЮ | стріми українською | 6:29:53 |
| 17. | Anza TNT | 303 | Serious Sam HD - The 2nd Encounter With AwesomeMattG ep. 15 | 34:20 |
| 18. | VTuber Zeromaster & Power Plays | 262 | Let's Fail Serious Sam Part 1 - I Srsly Suck | 20:32 |
| 19. | Yuri the Wolfbat | 144 | Cornerian Cafe Episode 41 Serious Sam is Seriously Insane Part 5 | 22:01 |
| 20. | Shadow The Lion Queen | 121 | How to unlock Drew Pickles in Serious Sam The Second Encounter | 9:12 |
| 21. | Klovac | 110 | Serious Sam The Second Encounter FULL GAME - Tourism Difficulty | 2:57:38 |
| 22. | Neon Henchman | 109 | Vertical Hunt: Sérieux [Mod] Contient peut-être de la chasse à la verticale | 21:57 |
| 23. | Filthy Casual VR | 105 | [VR] Serious Sam: The Second Encounter P1 | 2:33:06 |
| 24. | DigitalRossGamingStation | 94 | Serious Sam: The Second Encounter | Xbox Series X | Longplay | Co-op | Full Game Walkthrough | | 4:07:31 |
| 25. | GamingTiger | 70 | SERIOUS SAM: The Second Encounter | Part 17 - END | GamePlay (2020) | WalkThrough on STADIA | HD | | 7:48 |
| 26. | AilaChu Vods | 61 | Aila Plays Serious Sam - Final Boss | 4:25:49 |
| 27. | The Silly Steve Show | 32 | Serious Sam: The Second Encounter - Part 2 | 13:53 |
| 28. | Masumi | 30 | [VOD] Serious Sam: The Second Encounter Part 2 | 4:21:28 |
| 29. | Matthew Doucette (Xonatron) | 29 | Serious Sam HD: The Second Encounter (PC) - Episode: South America - Difficulty: Serious | 1:58:29 |
| 30. | Jon Renish | 22 | Steam Cleaning - Serious Sam Classic: The Second Encounter | 8:18 |
| 31. | BanAnERpH0N3 | 22 | Possibly A Short DLC Serious Sam Second Encounter LOTB DLC PS4 Part 1 Ending | 1:58:29 |
| 32. | No_Way301 | 15 | First Level - PrIm - Serious Sam: The Second Encounter HD - Xbox 360 | 25:41 |
| 33. | The Detective on Twitch | 13 | Steam Backlog Series: Serious Sam - The Second Encounter | 10:25 |
| 34. | HyruleChosenOne | 13 | Serious Sam TSE | 26:55 |
| 35. | Gormo | 10 | Serious Sam: The Second Encounter, Teotihuacan - Serpent Yards skip | 1:19 |
| 36. | Monument | 7 | Serious Sam Second Encounter (Fusion) - Grand Cathedral (NGH Community Night) | 26:13 |
| 37. | PanAnning | 7 | SERIOUS COOP - Session 4 | 1:26:20 |
