| 1. |  Annoying Orange Gaming | Annoying Orange Plays - SLITHER.IO: #1 BIGGEST SNAKE!!! | 11,225 | Let's Play |
| 2. | FGTeeV | SLITHER.io #2: vs. AGAR.io #4 vs. SUPER SNAKE.io #1 (FGTEEV Duddy Plays & Ranks All 3!! Favorite??) | 6,091 | Let's Play |
| 3. | Annoying Orange Gaming | Annoying Orange Plays - Slither.io #2 | 2,836 | Let's Play |
| 4. | SeeDeng | SANS PLAYS SLITHER.IO (Undertale Roleplay) | 769 | Let's Play |
| 5. | iX | MOPE.IO 200 IQ PLAYS!! // Best New Trolling (Mope.io Funny Moments) | 727 | Let's Play |
| 6. | SuperMega | SuperMega Plays SLITHER.IO - EP 1: Snake Eat Snake World | 599 | Let's Play |
| 7. | ToonFirst | Slither.io - Slitherio Monster Love | Epic Plays | 576 | Let's Play |
| 8. | ToonFirst | Slither.io - The Highest Risky Plays #2 | Slitherio Epic Moments | 446 | Let's Play |
| 9. | lonniedos | SLITHER.IO - THE NEW AGAR.IO with SNAKES! (iPhone Gameplay Video) | 382 | Let's Play |
| 10. | OtakMori Vtuber Clips | Okayu's Personality Changed When She Plays Slither.io【Hololive | Eng Sub】 | 362 | Let's Play |
| 11. | Be Challenger | FAKER Plays Slither.io and Gets TOP 1! - SKT T1 Faker Playing Slither.io (Reupload) | SKT T1 Replays | 335 | Let's Play |
| 12. | DOLLASTIC PLAYS! | Dragon Slither.io in Roblox?!?!!!! - Roblox Dragon Riders - DOLLASTIC PLAYS! | 323 | Let's Play |
| 13. | ToonFirst | Slither.io - World No.1 Sneaky Snake | Slitherio Epic Plays | 305 | Let's Play |
| 14. | Annoying Orange Gaming | Grapefruit Plays - Slither.io: GIANT KILLER CATERPILLER! | Annoying Orange | 301 | Let's Play |
| 15. | SuperMega | SuperMega Plays SLITHER.IO - EP 2: Moist Snakes | 286 | Let's Play |
| 16. | ToonFirst | Slither.io - Lovely Jelly Skin Invasion | Slitherio Plays | 286 | Let's Play |
| 17. | k3lp | Swordz.io - LEVEL 26 IN PVP MODE // 144.450 SCORE LEVEL MAX (WORLD RECORD) - k3lp | 253 | Let's Play |
| 18. | Annoying Orange Gaming | Gaming Grape Plays - SLITHER.IO Pewdie Pie Spotting!! | 244 | Let's Play |
| 19. | ToonFirst | Slither.io - Pokemon Go Snake 'Gotta Get Them ALL' | Slitherio Epic Plays | 226 | Let's Play |
| 20. | ToonFirst | Slither.io - Small Trolling World Biggest Giant Snake | Slitherio Funny Plays | 223 | Let's Play |
| 21. | ToonFirst | Slither.io - Small Trolling World Biggest Giant Snake | Slitherio Funny Plays | 220 | Let's Play |
| 22. | ToonFirst | Slither.io - PVZ Chomper Snake World Biggest Snake | New Custom Skin Epic Plays | 215 | Let's Play |
| 23. | ToonFirst | Slither.io - Boost Only Challenge | Slitherio Trolling Plays | 211 | Let's Play |
| 24. | ToonFirst | Slither.io - Small Vs Giants w/ New Invisible Ninja Skin | Slitherio Epic Plays | 211 | Let's Play |
| 25. | lonniedos | Slither.io - WORST THING THAT CAN EVER HAPPEN IN SLITHERIO - Part 2 (iPhone Gameplay Video) | 206 | Let's Play |
| 26. | ZaiLetsPlay | EAT THE BOOTY! - Slither.io | 204 | Let's Play |
| 27. | YuB | SLITHER.IO IS PRETTY FUN! [Slitherio Gameplay Highlights] | 198 | Let's Play |
| 28. | ToonFirst | Slither.io - New Cutest Cone Head Skin | Slitherio Plays | 187 | Let's Play |
| 29. | ToonFirst | Slither.io - Minecraft Snake Enderman | Slitherio Epic Plays | 181 | Let's Play |
| 30. | ToonFirst | Slither.io - The Cutest DOGE Snake - Slitherio Epic Plays | 178 | Let's Play |
| 31. | ToonFirst | Slither.io - Epic Small Trolling Giant Snakes | Slitherio Epic Plays | 171 | Let's Play |
| 32. | ToonFirst | Slither.io - World Biggest MLG Snake | New Spiderman Skin - Slitherio Epic Plays | 154 | Let's Play |
| 33. | GrayStillPlays | STARVE.IO - FREE SURVIVAL BASE BUILDING GAME! 1st Place Leaderboard - Starve.io Gameplay Highlights | 151 | Let's Play |
| 34. | ToonFirst | Slither.io - Super Giant Mario Bros. Snake | Slitherio Epic Plays | 147 | Let's Play |
| 35. | ToonFirst | Slither.io - Epic Snake Vs Giants w/ Most Risky Plays | 138 | Let's Play |
| 36. | ToonFirst | Slither.io - Tiny Snakes Everywhere | Slitherio Awesome Plays | 128 | Let's Play |
| 37. | biggranny000 | [Slither.io] - Lets Play Ep 1 - Our First Adventure! | 122 | Let's Play |
| 38. | k3lp | Evowars.io - PROTECT THE ORBS! // HUGE PILE OF ORBS! (new minigame + lvl.0 dark night!) - k3lp | 122 | Let's Play |
| 39. | ToonFirst | Slither.io - All Diamond Minecraft Skins Plays - Slitherio Epic Plays | 118 | Let's Play |
| 40. | ToonFirst | Slither.io - The Return Of King Giant Snake Trolling | Slitherio Epic Plays | 107 | Let's Play |
| 41. | ToonFirst | Slither.io - Evil Scary Snake w/ Trolling Giant Snakes - Slitherio Epic Plays | 102 | Let's Play |
| 42. | ToonFirst | Slither.io - Giant Happy Snakes Dominator | Slitherio Epic Plays | 101 | Let's Play |
| 43. | ToonFirst | Slither.io - Small Troll Vs Giant Snakes - Slitherio Epic Plays | 99 | Let's Play |
| 44. | ToonFirst | Slither.io - Giant Snakes Eat Small Weedle w/ Pokemon Go Mod | Slitherio Epic Plays | 98 | Let's Play |
| 45. | Annoying Orange Gaming | The Snakes are Back!!! (AO Plays Slither.io) | 96 | Let's Play |
| 46. | ToonFirst | Slither.io - I Can't 'Do' It w/o Hacking | Slitherio Epic Plays | 92 | Let's Play |
| 47. | ToonFirst | Slither.io - Legendary Epic Snake Vs Giants w/ Most Risky Plays | 91 | Let's Play |
| 48. | KittyPlays | BIGGEST SLITHER RECORD EVER 69696 SLITHER QUEEN! (Slither.io Gameplay) | Kitty Plays | 90 | Let's Play |
| 49. | GrayStillPlays | STARVE.IO AWESOME UPDATE - Diamond Spear, Animal Fur Armor, Furnace! - Starve.io Gameplay Highlights | 90 | Let's Play |
| 50. | ToonFirst | Slither.io - All Pokemon Go ( Mewtwo ) New Skins | Slitherio Epic Plays | 83 | Let's Play |
| 51. | ToonFirst | Slither.io - What A Moment Like This | Slitherio Plays | 78 | Let's Play |
| 52. | Emerald Masters | Knuckles plays Slither.io | 75 | Let's Play |
| 53. | ToonFirst | Slither.io - Big Daddy & Mommy Snakes | Slitherio Epic Plays | 73 | Let's Play |
| 54. | PracticalPat | I WRECKED PEWDIEPIE IN SLITHER.IO (JustLife Plays EP.1) | 72 | Let's Play |
| 55. | ToonFirst | Slither.io - Mrs. Pacman Snake Vs Biggest Giant | Slitherio Epic Plays | 72 | Let's Play |
| 56. | Slither Sessions | Slither.io Speed Kills No. 1 | Slitherio Epic Plays | Slither Sessions Mods New Skin | 72 | Let's Play |
| 57. | React Archive | xQc Plays Slither.io | 64 | Let's Play |
| 58. | ToonFirst | Slither.io - Fast Furious As Sonic Snake - Slitherio Epic Plays | 63 | Let's Play |
| 59. | loltyler1 | TYLER1 PLAYS SLITHER.IO #1 | 59 | Let's Play |
| 60. | GrayStillPlays | Slither.io | Rage, Funny Moments, Fails, Highlight Compilation Montage | Want to Hear Gray Cuss?! | 57 | Let's Play |
| 61. | DraaxLP | Slither.IO Gameplay - Ep 1 - Help Me! | 56 | Let's Play |
| 62. | Kaceytron | High Level Worm Game Plays | 50 | Let's Play |
| 63. | KittyPlays | HOW TO BE BEST SLITHER PLAYER IN THE WORLD! (Slither.io Gameplay) | Kitty Plays | 48 | Let's Play |
| 64. | k3lp | Evowars.io - PROTECT THE ORBS! // HUGE PILE OF ORBS! (new minigame part two!) - k3lp | 47 | Let's Play |
| 65. | Waffle Bros | CORWIN'S MASSIVE SNAKE IS NUMBER ONE! -- Let's Play Slither.io (Free Web Game) | 39 | Let's Play |
| 66. | Skarrow9 | Skarrow9 Plays Slither.io!! | 37 | Let's Play |
| 67. | AdamBomb | SLITHER.IO: SNAKES EATING SNAKES? (Let's Play SLITHER.IO Gameplay) | 35 | Let's Play |
| 68. | lonniedos | ORBSORB (iPad Gameplay Video) | 32 | Let's Play |
| 69. | GrayStillPlays | GrayStillPlays Channel Update! New Upload Schedule, New Channel Art, New Computer, LOVE YOU FOLKS! | 31 | Let's Play |
| 70. | k3lp | Limax.io - 1,345,392 SCORE // *NEW* WORLD RECORD! (game like slither.io) - k3lp | 26 | Let's Play |
| 71. | TheGameHuntah Gaming | Slither.io | My NEW Addiction | Agario with Worms? | 24 | Let's Play |
| 72. | YungSG | Let's Play Slither.io Going For #1!!! | 24 | Let's Play |
| 73. | MumblesVideos | Slither.io Episode 4 || Lets get Wormy with it!! || Mumbles Videos Lets Play! | 22 | Let's Play |
| 74. | Ал Плей | Slither.io,Wormax.io,Little Big Snake,Wormate.io,Gulper.io,Slithercraft.io,Andry Snakes,Sworm.io | 21 | Let's Play |
| 75. | ToonFirst | Slither.io - New Invisible Ninja Skin w/ Ninja Blade - Slitherio Epic Plays | 18 | Let's Play |
| 76. | Cool Cat Videos | Let's play Slither.io ios | Playing Slither on our new iPad | Shooting for First | Cool Cat Videos | 18 | Let's Play |
| 77. | JJO | Slither.io secret skin to help you win! Hack | 17 | Let's Play |
| 78. | Heath Haskins | Heath Plays Slither.io - Time Lapse | 17 | Let's Play |
| 79. | Cool Cat Videos | Let's play Slither.io ios | Playing Slither on our new iPad | New High Score | Cool Cat Videos | 17 | Let's Play |
| 80. | Slither Sessions | Slither.io Speed Kills No. 2 | A Quick 31k | Slitherio Epic Plays | Slither Sessions | 16 | Let's Play |
| 81. | ToonFirst | Slither.io - 4th July New Custom World Biggest Snake | New Skin Slitherio Epic Plays | 16 | Let's Play |
| 82. | Brotacular | QUAD KILL! | Slither.io Ep.1 | 16 | Let's Play |
| 83. | MumblesVideos | Slither.io #5 || Giant Worm ! || Mumbles Videos Let's Play | 16 | Let's Play |
| 84. | RoyLT | 2ND BIGGEST SNAKE IN THE WORLD!! | Roy Plays Slither.io | 16 | Let's Play |
| 85. | Jonnii | Let's Play - Slither.io #1 Gameplay | Classic Snake Revamped! | Blind Playthrough | Funny Moments | 15 | Let's Play |
| 86. | Expel | "MAKING HUGE PLAYS!" - SLITHER.IO! | 15 | Let's Play |
| 87. | Bagoyee | INVISIBLE NINJA SNAKE IS #1 | NEW SLITHER.IO SKIN MOD HACK | 14 | Let's Play |
| 88. | OhcluckToys | Random Blind Bag Box Episode #494 - Care Bears, Smooshy Mushy, MLP, Panda Da Panda, Slither.io Plush | 14 | Let's Play |
| 89. | JBOB | Insane Plays in Slither.io | 14 | Let's Play |
| 90. | Shopking | Lets Play & Fail At Slither.io - How Not To Play Slither! | Shopking | 13 | Let's Play |
| 91. | Shopking | Lets Play Slither.io ✪ The Circle Of Doom ✪ New High Score | Shopking | 12 | Let's Play |
| 92. | Bagoyee | DONALD TRUMP | NEW SECRET SLITHER.IO HACK SKIN MOD | 12 | Let's Play |
| 93. | Bagoyee | DEADPOOL IS #1 | NEW SECRET SLITHER.IO SKIN HACK MOD | 12 | Let's Play |
| 94. | Max Patiiuk | Slither.io #2. 10000+ EPIC. AGARIO 2 | 11 | Let's Play |
| 95. | duffking56 | Let's Play: Borderlands - Episode 52 - Slither! | 11 | Let's Play |
| 96. | KeepCalmAndGameOn | GameStop Snake? - Let's Play: Slither.io | 10 | Let's Play |
| 97. | TheTekkitRealm | SLITHER ME DADDY! - Slither.io Game | 10 | Let's Play |
| 98. | Heavy Metal Gamer Show | Heavy Metal Gamer Plays: Slither.io - Episode 2 | 9 | Let's Play |
| 99. | Waffle Bros | RE-TASTING THE SNAKE RAINBOW! -- Let's Play Slither.io (Free Web Game) | 9 | Let's Play |
| 100. | WavePunk | WavePunk Plays Slither.io [Lets Play] | 9 | Let's Play |
