| 201. |  zKemsyt | 15 | The Binding of Isaac: Il nuovo DLC è fantastico + COOP 3 giocatori | 3:10:03 |
| 202. | Zio Cabinato | 14 | Utero - Difficulty Hard - The Binding of Isaac [Gameplay] | 16:50 |
| 203. | Natron3031 | 12 | THE BINDING OF ISAAC - Episodio 1 [Povero Isaac... e povero me!] | 27:20 |
| 204. | Forretress Creations | 12 | Live reaction dell'Ignoto su Isaac | 0:00 |
| 205. | ferrogigio - Twitch VODs | 12 | G&J | Isacco in Compagnia del CEO del Sium Binding of Isaac | 2:05:21 |
| 206. | Digirorth | 12 | [Just Playing] The Binding of Isaac #07 - Il Potere del Vampiro | 24:42 |
| 207. | Game Tales | 12 | THE BINDING OF ISAAC - PC Game - Gameplay 2 | 47:23 |
| 208. | La Tana del Drago | 12 | [The Binding Of Isaac]-Mai Guardare Programmi Religiosi | 15:57 |
| 209. | PandaGalo | 11 | "Morte e Bot(te)" - The Binding Of Isaac Blind Run [3] | 50:40 |
| 210. | Ven's Random Footage | 11 | The Binding of Isaac [524] - An out of control switch | 0:00 |
| 211. | Macs del MangaMe | 11 | The Binding of Isaac #1 | 1:47:26 |
| 212. | Streghetta Channel | 10 | The Binding Of Isaac | 1:00:57 |
| 213. | Bandrum_ | 10 | Tutti nel sotterraneo - The Binding of Isaac | 0:00 |
| 214. | NickName ITA | 10 | The Binding of Isaac EP. 0 | 22:46 |
| 215. | MDM | 10 | MAGDALENE - The Binding of Isaac | ["Blind Run" #4] | 1:51:41 |
| 216. | Frency0311 | 10 | [ENG/ITA]The Binding of Isaac#3: Nuovi try | 1:06:05 |
| 217. | ILCoissaro | 10 | Voglia del Momento - Incredibile patch! | 1:55:39 |
| 218. | yuukicyan | 9 | Am I really doing this? - Playing for the first time! | The BINDING OF ISAAC - Twitch VOD | 2:47:20 |
| 219. | RVAngelus | 9 | Chiacchiere e The Binding of isaac | 3:08:46 |
| 220. | Vinnik | 8 | The Binding Of Isaac! -42 a Demon's Souls! | 1:38:38 |
| 221. | ILCoissaro's Adventures | 8 | Voglia del Momento - Sconfitte a manetta... | 2:08:52 |
| 222. | UniversalNoire | 8 | La mia primissima partita a The Binding of Isaac! | 24:47 |
| 223. | Bughere3 | 8 | The Binding of Isaac - io ci Provo Anche se... | 0:05 |
| 224. | GRANDEMUR | 7 | The Binding of Isaac -Jera!- | 0:30 |
| 225. | SpookyGurki | 7 | isaac #6 | 38:15 |
| 226. | 3val3ntur | 7 | the binding of isaac random runs | 1:07:20 |
| 227. | Perry48 | 7 | The Binding Of Isaac #1 - Una morte stupida | 17:54 |
| 228. | Soshemi Twitch | 6 | Proviamo Lilith (pessima idea) e la boss rush - The Binding Of Isaac | 2:41:59 |
| 229. | FullmetalRoccia | 6 | Blade Strangers: per il mio amico fan di The Binding of Isaac | 0:00 |
| 230. | SafariGames Archivio Live Twitch | 6 | THE BINDING OF ISAAC: Lacrime e Sangue con ORSOPUNK !orso | 1:53:16 |
| 231. | Lucky Janken | 5 | LIVE ABUSIVA n°2 - Il vero finale finalissimo true truest ending! (Forse) - The Binding of Isaac | 2:07:43 |
| 232. | Lumiiere | 5 | SCONFIGGO GULPY!!!! THE BINDING OF ISAAC! | 13:12 |
| 233. | Araknie Plays It Retro | 5 | Araknie's Farewell to Flash | 4:34:17 |
| 234. | Promaster24 | 5 | -The Binding Of Isaac-SONO SCARSO-Ep 1-ITA | 14:11 |
| 235. | Gli Antroversi Archive | 4 | Funny fiend mod - Binding of Isaac moddato con un modder [Fillo] | 1:53:00 |
| 236. | Dalyvengenz | 3 | OTTIMA run! [Azazel] - The Binding of Isaac | 22:01 |
| 237. | Exa | 3 | The Binding of Isaac: Chaos Run with Cain VS DELIRIUM | 0:00 |
| 238. | Mirax | 3 | Mistero : The Binding of Isaac | 1:00:40 |
| 239. | CodystormTube | 2 | Gameplay Varietà 42: The Binding of Isaac | 0:00 |
| 240. | Archivio ParliamonePod | 2 | Fissato con The Binding of Isaac - L'angolo di Lattu [TWITCH] | 1:14:45 |
| 241. | CDKEYIT | 2 | Top 15 Best Pixel Art Games - June 2021 Selection | 5:07 |
| 242. | OnijiGaming87 | 1 | The binding of Isaac EP 1 - Prime partite | 1:02:05 |
| 243. | Ierias | 1 | Isaac tranquillo senza pretese. No davvero, non aspettatevi niente di che - The Binding of Isaac | 1:47:23 |
| 244. | RinnosukeKuto | 0 | [Twitch][PC] Just for fun - The Binding of Isaac | 2:26:39 |
