| 1. |  Rob Flynn (Wolverous) | The Binding Of Isaac: Wrath Of The Lamb - Episode 4 | 8:53:01 | Let's Play |
| 2. | Rob Flynn (Wolverous) | The Binding Of Isaac: Wrath Of The Lamb - Episode 2 | 8:39:28 | Let's Play |
| 3. | Rob Flynn (Wolverous) | The Binding Of Isaac: Wrath Of The Lamb - Episode 1 | 8:28:40 | Let's Play |
| 4. | Rob Flynn (Wolverous) | The Binding Of Isaac: Wrath Of The Lamb - Episode 3 | 8:23:37 | Let's Play |
| 5. | Rob Flynn (Wolverous) | The Binding Of Isaac: Wrath Of The Lamb - Episode 5 | 7:39:28 | Let's Play |
| 6. | Jabroni Mike Full Streams | The Binding of Isaac (and Smash with Chat!) - 01/17/19 - Jabroni Mike Full Streams | 5:31:00 | Let's Play |
| 7. |  CedSphere | LE PATRON DES ROGUE-LITE ! 👶💩 | The Binding Of Isaac (01) | 5:09:16 | Let's Play |
| 8. | YourLilBro | Rooki plays Binding of Isaac Part 9 | 5:07:54 | Let's Play |
| 9. | Lunar D8 | lets play isaac part 116 the chocolate on my cake is electricity | 5:07:40 | Let's Play |
| 10. | Jabroni Mike Full Streams | The Binding of Isaac - 06/12/19 - Jabroni Mike Full Streams | 4:35:14 | Let's Play |
| 11. | 13lackJ8ck | Ab in den Keller!☹️Schwerste Schwierigkeit: Schwer😎!daily[143/366] | 4:28:07 | Let's Play |
| 12. | wlvs archive | HELP ME DEREK YU 😤 | OCTOBER 9TH 2020 [TWITCH VOD] | SPELUNKY 2 + THE BINDING OF ISAAC | 4:14:54 | Let's Play |
| 13. | YourLilBro | Rooki plays Binding of Isaac Part 10 | 4:03:13 | Let's Play |
| 14. |  OniGamer | um uh Isaac n stuff idk what to title this help | 3:56:47 | Let's Play |
| 15. | Jabroni Mike Full Streams | Afterbirth + - Jabroni Mike: Full Streams | 3:56:26 | Let's Play |
| 16. | Fuerutar | Great Steam Library Playthrough: Episode 57 | 3:53:37 | Let's Play |
| 17. | Jabroni Mike Full Streams | BoI Antibirth 1/29/17 - Jabroni Mike: Full Streams | 3:49:08 | Let's Play |
| 18. | YourLilBro | Rooki plays Binding of Isaac Part 6 | 3:49:02 | Let's Play |
| 19. |  DRAK | [LP] Dracek.cz - LS : The Binding of Isaac + Monaco "cz" - [HD] | 3:49:00 | Let's Play |
| 20. | Jabroni Mike Full Streams | The Binding of Isaac AB + 3/22/17 - Jabroni Mike: Full Streams | 3:30:14 | Let's Play |
| 21. | Indelacio.co.uk : Lets Plays and Game Reviews | Ziggurat Single Play Doom meets The Binding Of Isaac With Wands #ziggurat #singleplay #rotuelike | 3:29:46 | Let's Play |
| 22. | bobfleadip | AGNB Plays: The Binding of Isaac - Episode 160 | 3:26:12 | Let's Play |
| 23. | RitualCub (RitualCub) | Lets Play: Stream "The Binding of Issac" part 5 | 3:16:05 | Let's Play |
| 24. | CedSphere | J' ENCHAÎNE LES RUNS (Et c'est pas beau à voir) ! 💩👶 | The Binding Of Isaac (04) | 3:11:27 | Let's Play |
| 25. | CedSphere | 💩 ON SE FAIS UNE DERNIÈRE RUN ? | The Binding Of Isaac (05) | 3:10:15 | Let's Play |
| 26. | Daniel Cornwall | Lets Play the Binding of Isaac Part 96(Multiplayer Madness) | 3:09:16 | Let's Play |
| 27. | Dutchtuber | ( LIVE )The Binding of Isaac - Lets Play - Episode 4 - [Walkthrough / Playthrough] | 3:07:00 | Let's Play |
| 28. | Daniel Cornwall | Lets Play the Binding of Isaac Part 95(Fuck Greedier Mode) | 3:06:55 | Let's Play |
| 29. | Jabroni Mike Full Streams | The Binding of Isaac - 05/31/19 - Jabroni Mike Full Streams | 3:05:55 | Let's Play |
| 30. | Jabroni Mike Full Streams | The Binding of Isaac - 03/20/19 - Jabroni Mike Full Streams | 3:04:53 | Let's Play |
| 31. | Jabroni Mike Full Streams | The Binding of Isaac AB+ - 2/8/18 - Jabroni Mike Full Streams | 3:02:33 | Let's Play |
| 32. | Daniel Cornwall | Lets Play the Binding of Isaac Part 106(Enjoy The Lightshow) | 2:57:25 | Let's Play |
| 33. | Jabroni Mike Full Streams | Afterbirth + - Jabroni Mike: Full Streams | 2:55:22 | Let's Play |
| 34. |  Moth Girl Hina | The Binding of Isaac Save File 2: Broken Modem [VTUBER] | 2:52:58 | Let's Play |
| 35. | Moth Girl Hina | Unlocking All Tarnished Characters [VTUBER] | 2:52:31 | Let's Play |
| 36. | Moth Girl Hina | How to Rig a New Isaac Save [VTUBER] | 2:50:54 | Let's Play |
| 37. | CedSphere | ON N'EN CHIERAIT PAS UN PETIT PEU LÀ ? 😵 | The Binding Of Isaac (02) | 2:48:26 | Let's Play |
| 38. | SnizzleLive | The Binding of Isaac - Livestream Special | Let's Play The Binding of Isaac | 2:47:36 | Let's Play |
| 39. | Daniel Cornwall | Lets Play the Binding of Isaac Part 100(Hot Shit) | 2:46:23 | Let's Play |
| 40. | YourLilBro | Rooki plays The binding of Isaac Part 8 | 2:44:30 | Let's Play |
| 41. | Jabroni Mike Full Streams | The Binding of Isaac - 11/23/2018 - Jabroni Mike Full Streams | 2:44:27 | Let's Play |
| 42. | TraBombVods | The Binding Of Isaac Playthrough: File 3 ep.20 Judas Greed, Eve Greed, Cain, and Eden Runs | 2:42:55 | Let's Play |
| 43. | Daniel Cornwall | Lets Play the Binding of Isaac Part 141(Give Me The Formuoli) | 2:40:54 | Let's Play |
| 44. | Jabroni Mike Full Streams | Isaac on Twitch - Jabroni Mike: Full Streams | 2:40:31 | Let's Play |
| 45. | Daniel Cornwall | Lets Play the Binding of Isaac Part 105(My Huge Bone) | 2:39:27 | Let's Play |
| 46. | Daniel Cornwall | Lets Play the Binding of Isaac Part 126(Annoyed Grunt the Pain of it All) | 2:38:53 | Let's Play |
| 47. | Daniel Cornwall | Lets Play the Binding of Isaac Part 129(Stay Out of My Sweet Spot) | 2:38:22 | Let's Play |
| 48. | Vencabot | [The Binding of Isaac] First playthrough! Thanks, Undead_Kaiju! Amazing roguelike | 2:35:51 | Let's Play |
| 49. | Daniel Cornwall | Lets Play the Binding of Isaac Part 151(Coming the Raw Egg) | 2:34:45 | Let's Play |
| 50. | L'Ermite Moderne | [Spécial Halloween] The Binding of Isaac : l'aventure infernale (let's play géant) | 2:34:38 | Let's Play |
| 51. | Vidyacraft | Sroxah plays The Binding Of Isaac till ragequit | 2:34:17 | Let's Play |
| 52. | Daniel Cornwall | Lets Play the Binding of Isaac Part 154(Don't Count Your Blessings) | 2:32:22 | Let's Play |
| 53. | Daniel Cornwall | Lets Play the Binding of Isaac Part 98(D20 Exploit) | 2:31:57 | Let's Play |
| 54. | Daniel Cornwall | Lets Play the Binding of Isaac Part 97(Big 1 Cent Donation) | 2:31:51 | Let's Play |
| 55. | Daniel Cornwall | Lets Play the Binding of Isaac Part 104(Keeper Steady) | 2:31:42 | Let's Play |
| 56. | BeefyTatersPlays | The Binding of Isaac| Can a Tater Cry?!!? | BeefyTatersPlays | 2:30:41 | Let's Play |
| 57. | Moth Girl Hina | It Dies [VTUBER] | 2:29:41 | Let's Play |
| 58. | Daniel Cornwall | Lets Play the Binding of Isaac Part 103(The Unhittable Duo) | 2:29:27 | Let's Play |
| 59. | Retro World Order | Let's Play Variety and Requests | 2:27:39 | Let's Play |
| 60. | Daniel Cornwall | Lets Play the Binding of Isaac Part 130(Grist For The Mill) | 2:26:51 | Let's Play |
| 61. | Daniel Cornwall | Lets Play the Binding of Isaac Part 150(Avoid the Void) | 2:26:19 | Let's Play |
| 62. | Daniel Cornwall | Lets Play the Binding of Isaac Part 110(Psyachnid) | 2:26:10 | Let's Play |
| 63. | Daniel Cornwall | Lets Play the Binding of Isaac Part 145(Gay Or Just Pyramid Scheme?) | 2:25:50 | Let's Play |
| 64. | Daniel Cornwall | Lets Play the Binding of Isaac Part 116(Andrew Ryan: The Best Nac Mac Feegle) | 2:25:34 | Let's Play |
| 65. | LARRY | Binding of Isaac 1001% Playthrough - Episode #19 | 2:25:27 | Let's Play |
| 66. | Daniel Cornwall | Lets Play the Binding of Isaac Part 156(This Suit Burns Better) | 2:25:04 | Let's Play |
| 67. | bisnap | Let's Play The Binding of Isaac Episode 110 - Stream | 2:24:54 | Let's Play |
| 68. | Daniel Cornwall | Lets Play the Binding of Isaac Part 186(Fresh Air) | 2:24:39 | Let's Play |
| 69. | Trap Kermit | More Isaac LETS GO!!! | 2:24:26 | Let's Play |
| 70. | Daniel Cornwall | Lets Play the Binding of Isaac Part 101(Mommy Scramble) | 2:24:10 | Let's Play |
| 71. | Deafinition | Let's Play the Binding of Isaac Pt. 97 - The Wonkiest Butthole | 2:23:22 | Let's Play |
| 72. | Dhalucard - Extra Content | Nur eine TESTRUNDE - TableTop Simulator: The Binding of Isaac Four Souls - Dhalucard | 2:23:01 | Let's Play |
| 73. | Daniel Cornwall | Lets Play the Binding of Isaac Part 109(Going For Broke) | 2:23:00 | Let's Play |
| 74. | Jabroni Mike Full Streams | The Binding of Isaac - 11/14/18 (part 2!) - Jabroni Mike Full Streams | 2:21:29 | Let's Play |
| 75. | Jabroni Mike Full Streams | The Binding of Isaac - 07/04/19 - Jabroni Mike Full Streams | 2:21:12 | Let's Play |
| 76. | Daniel Cornwall | Lets Play the Binding of Isaac Part 162(Tiny Baby) | 2:21:10 | Let's Play |
| 77. | WotC Plays | WotC Plays: Binding of Isaac (#30) | 2:20:24 | Let's Play |
| 78. | Daniel Cornwall | Lets Play the Binding of Isaac Part 99(You Merely Adopted The Greed) | 2:20:14 | Let's Play |
| 79. | Daniel Cornwall | Lets Play the Binding of Isaac Part 107(Blessed Stream) | 2:19:08 | Let's Play |
| 80. | Daniel Cornwall | Lets Play the Binding of Isaac Part 131(Bumbotrayal) | 2:18:57 | Let's Play |
| 81. | Daniel Cornwall | Lets Play the Binding of Isaac Part 155(The Ballad of Bad Tom) | 2:17:20 | Let's Play |
| 82. | Daniel Cornwall | Lets Play the Binding of Isaac Part 114(Esau Is Not Fooled By Your Undies) | 2:16:36 | Let's Play |
| 83. | Daniel Cornwall | Lets Play the Binding of Isaac Part 138(Triple Bone) | 2:16:36 | Let's Play |
| 84. | Daniel Cornwall | Lets Play the Binding of Isaac Part 125(Tainted Lost Best Character) | 2:15:59 | Let's Play |
| 85. | Daniel Cornwall | Lets Play the Binding of Isaac Part 142(The Canada of the South) | 2:15:04 | Let's Play |
| 86. | Daniel Cornwall | Lets Play the Binding of Isaac Part 171(Based And Khans-Pilled) | 2:14:30 | Let's Play |
| 87. | Daniel Cornwall | Lets Play the Binding of Isaac Part 113(Accidental Manual Fever) | 2:13:52 | Let's Play |
| 88. | Fakyra XOXO ASMR | 👾 Let's Play 👾 "Binding of Isaac is and easy game" #vtuber #twitch #letsplay | 2:12:34 | Let's Play |
| 89. | Daniel Cornwall | Lets Play the Binding of Isaac Part 157(So Long, Tainted Lost!) | 2:12:17 | Let's Play |
| 90. |  AlemDaLenda | Playstream - Jogando Isaac aqui de bobeira | 2:11:59 | Let's Play |
| 91. | Daniel Cornwall | Lets Play the Binding of Isaac Part 190(Death Radius) | 2:11:12 | Let's Play |
| 92. | Daniel Cornwall | Lets Play the Binding of Isaac Part 185(Radioactive) | 2:10:36 | Let's Play |
| 93. | The Defective Butcher | LET'S GET HELLA SCARED LIVE!!! (Dungeon Nightmares 3, SCP Unity, The Binding of Isaac) | 2:10:14 | Let's Play |
| 94. | Daniel Cornwall | Lets Play the Binding of Isaac Part 178(Shit Runs) | 2:09:36 | Let's Play |
| 95. | Daniel Cornwall | Lets Play the Binding of Isaac Part 132(Philippa Misreads Wiki, Naps) | 2:08:45 | Let's Play |
| 96. | Daniel Cornwall | Lets Play the Binding of Isaac Part 153(Keeper of Camo) | 2:08:43 | Let's Play |
| 97. | GameJam Deutschland | Ich liebe es da es ein spannender Run wird! in The Binding of Isaac | Let's play German / Deutsch | 2:08:08 | Let's Play |
| 98. | Daniel Cornwall | Lets Play the Binding of Isaac Part 160(Rejigger) | 2:07:57 | Let's Play |
| 99. | Daniel Cornwall | Lets Play the Binding of Isaac Part 149(Almond Cake) | 2:06:51 | Let's Play |
| 100. | Eman-san | The Binding of Eman 11: The First Woman | 2:06:31 | Let's Play |
