| 2025-05-03 | omnipian | Omnipian Plays The Binding of Isaac - Part 312 | 54:55 | 29 |
| 2024-08-03 | omnipian | Omnipian Plays The Binding of Isaac - Part 276 | 43:29 | 14 |
| 2024-07-29 | Daniel Cornwall | Lets Play the Binding of Isaac Part 194(Should've Eaten The Scooper) | 1:30:57 | 1 |
| 2024-07-27 | Daniel Cornwall | Lets Play the Binding of Isaac Part 193(Bully For Me) | 1:30:50 | 7 |
| 2024-07-27 | omnipian | Omnipian Plays The Binding of Isaac - Part 275 | 47:09 | 24 |
| 2024-07-20 | omnipian | Omnipian Plays The Binding of Isaac - Part 274 | 36:45 | 23 |
| 2024-07-13 | omnipian | Omnipian Plays The Binding of Isaac - Part 273 | 50:01 | 11 |
| 2024-07-08 | Daniel Cornwall | Lets Play the Binding of Isaac Part 192(Piss Ring Babies) | 1:22:33 | 19 |
| 2024-07-08 | Daniel Cornwall | Lets Play the Binding of Isaac Part 191(Diabeetus) | 1:43:24 | 24 |
| 2024-07-06 | omnipian | Omnipian Plays The Binding of Isaac - Part 272 | 1:07:47 | 11 |
| 2024-06-29 | Daniel Cornwall | Lets Play the Binding of Isaac Part 190(Death Radius) | 2:11:12 | 6 |
| 2024-06-29 | omnipian | Omnipian Plays The Binding of Isaac - Part 271 | 55:45 | 12 |
| 2024-06-22 | Daniel Cornwall | Lets Play the Binding of Isaac Part 189(My Sacrifice) | 1:48:55 | 2 |
| 2024-06-22 | Daniel Cornwall | Lets Play the Binding of Isaac Part 188(Overbullying) | 1:43:20 | 1 |
| 2024-06-22 | omnipian | Omnipian Plays The Binding of Isaac - Part 270 | 49:55 | 28 |
| 2024-06-22 |  Ephrio | Cain vs Mom! | 1:23 | 101 |
| 2024-06-15 |  Thedrummer123 | What Ever Happened To The Game The Bindinf Of Isaac #gamingvideos #gaming #letsplays #gamers #short | 0:24 | 449 |
| 2024-06-15 | omnipian | Omnipian Plays The Binding of Isaac - Part 269 | 34:17 | 18 |
| 2024-06-15 | Ephrio | The "Bloat" boss versus Cain | 0:52 | 274 |
| 2024-06-11 | OniGamer | um uh Isaac n stuff idk what to title this help | 3:56:47 | 5 |
| 2024-06-08 | omnipian | Omnipian Plays The Binding of Isaac - Part 268 | 58:05 | 9 |
| 2024-06-08 | Ephrio | Cain versus Super Greed | 0:41 | 49 |
| 2024-06-03 | Daniel Cornwall | Lets Play the Binding of Isaac Part 187(Golden Army) | 1:32:19 | 0 |
| 2024-06-01 | omnipian | Omnipian Plays The Binding of Isaac - Part 267 | 41:36 | 7 |
| 2024-06-01 | Ephrio | Cain versus Sloth | 0:31 | 18 |
| 2024-05-28 | Daniel Cornwall | Lets Play the Binding of Isaac Part 186(Fresh Air) | 2:24:39 | 0 |
| 2024-05-25 | omnipian | Omnipian Plays The Binding of Isaac - Part 266 | 55:37 | 52 |
| 2024-05-25 | Ephrio | Cain vs The Wretched | 0:46 | 752 |
| 2024-05-24 | ExaggeratedElegy | Let's Play The Binding of Isaac: Daddy's Day. | 43:15 | 60 |
| 2024-05-22 |  13lackJ8ck | Ab in den Keller!☹️Schwerste Schwierigkeit: Schwer😎!daily[143/366] | 4:28:07 | 12 |
| 2024-05-20 | Daniel Cornwall | Lets Play the Binding of Isaac Part 185(Radioactive) | 2:10:36 | 3 |
| 2024-05-20 | Daniel Cornwall | Lets Play the Binding of Isaac Part 184(Keepin It Shitty) | 1:42:10 | 3 |
| 2024-05-20 | Daniel Cornwall | Lets Play the Binding of Isaac Part 183(And It Goes On Like This) | 1:46:40 | 5 |
| 2024-05-18 | omnipian | Omnipian Plays The Binding of Isaac - Part 265 | 54:10 | 12 |
| 2024-05-18 | Ephrio | The Fallen boss kontra Cain | 0:45 | 279 |
| 2024-05-17 | ExaggeratedElegy | Let's Play The Binding of Isaac: Using One's BRAINS. | 53:37 | 70 |
| 2024-05-12 | omnipian | Omnipian Plays The Binding of Isaac - Part 264 | 1:05:49 | 8 |
| 2024-05-11 | Ephrio | The Blighted Ovum kontra Cain | 0:26 | 203 |
| 2024-05-08 | ExaggeratedElegy | Let's Play The Binding of Isaac: Greed Double Bill | 59:58 | 49 |
| 2024-05-08 | Lunar D8 | lets play the binding of Infected Mushroom by Striccs part 1 no isaac gameplay just me explaining it | 16:00 | 17 |
| 2024-05-06 | omnipian | Omnipian Plays The Binding of Isaac - Part 263 | 1:12:43 | 2 |
| 2024-05-04 | Ephrio | Cain versus The Dukes of Flies | 1:36 | 233 |
| 2024-05-02 | omnipian | Omnipian Plays The Binding of Isaac - Part 262 | 52:06 | 6 |
| 2024-05-02 | ExaggeratedElegy | Let's Play The Binding of Isaac: Bethany Blitz! | 59:14 | 30 |
| 2024-04-29 | ExaggeratedElegy | Let's Play The Binding of Isaac: You Guessed It... | 31:05 | 38 |
| 2024-04-29 | ExaggeratedElegy | Let's Play The Binding of Isaac: Mother of Demons. | 55:57 | 61 |
| 2024-04-28 | omnipian | Omnipian Plays The Binding of Isaac - Part 261 | 49:29 | 8 |
| 2024-04-27 | Ephrio | Isaac kontra Chub | 1:02 | 258 |
| 2024-04-26 | ExaggeratedElegy | Let's Play The Binding of Isaac: Pay 2 Play. | 35:45 | 24 |
| 2024-04-25 | Daniel Cornwall | Lets Play the Binding of Isaac Part 182(That Lucky Old Shit) | 1:36:16 | 1 |
| 2024-04-25 | Daniel Cornwall | Lets Play the Binding of Isaac Part 181(Smell Is Not A Dimension) | 2:02:25 | 3 |
| 2024-04-24 | omnipian | Omnipian Plays The Binding of Isaac - Part 260 | 41:11 | 10 |
| 2024-04-20 | ExaggeratedElegy | Let's Play The Binding of Isaac: CURSED EYE IS CURSED. | 49:12 | 13 |
| 2024-04-20 | omnipian | Omnipian Plays The Binding of Isaac - Part 259 | 47:09 | 5 |
| 2024-04-16 | omnipian | Omnipian Plays The Binding of Isaac - Part 258 | 46:08 | 24 |
| 2024-04-13 | Ephrio | Maggy versus Chub (Blue) | 1:23 | 30 |
| 2024-04-12 | omnipian | Omnipian Plays The Binding of Isaac - Part 257 | 1:19:31 | 9 |
| 2024-04-08 | omnipian | Omnipian Plays The Binding of Isaac - Part 256 | 58:22 | 8 |
| 2024-04-07 | Daniel Cornwall | Lets Play the Binding of Isaac Part 180(Twirling Towards Freedom) | 1:45:58 | 2 |
| 2024-04-07 | Daniel Cornwall | Lets Play the Binding of Isaac Part 179(The Dignity You Deserve) | 2:01:40 | 0 |
| 2024-04-06 | ExaggeratedElegy | Let's Play The Binding of Isaac: Money in The Bank. | 47:00 | 34 |
| 2024-04-06 | Ephrio | Maggy vs Wrath | 0:52 | 97 |
| 2024-04-04 | omnipian | Omnipian Plays The Binding of Isaac - Part 255 | 46:06 | 19 |
| 2024-04-02 | ExaggeratedElegy | Let's Play The Binding of Isaac: ANOTHER VICTORY LAP? | 36:30 | 39 |
| 2024-03-31 | omnipian | Omnipian Plays The Binding of Isaac - Part 254 | 35:27 | 11 |
| 2024-03-30 | ExaggeratedElegy | Let's Play The Binding of Isaac: SPOOOOOOOOON! | 46:31 | 23 |
| 2024-03-30 | Ephrio | Maggy kontra Wrath (x2) | 0:46 | 17 |
| 2024-03-27 | omnipian | Omnipian Plays The Binding of Isaac - Part 253 | 45:07 | 14 |
| 2024-03-26 | Daniel Cornwall | Lets Play the Binding of Isaac Part 178(Shit Runs) | 2:09:36 | 0 |
| 2024-03-26 | Daniel Cornwall | Lets Play the Binding of Isaac Part 177(This Is Fart Town, Pretty Boy) | 1:44:58 | 4 |
| 2024-03-23 | omnipian | Omnipian Plays The Binding of Isaac - Part 252 | 54:17 | 2 |
| 2024-03-23 | Ephrio | Lokii boss | The Binding of Isaac | 0:44 | 43 |
| 2024-03-19 | omnipian | Omnipian Plays The Binding of Isaac - Part 251 | 34:47 | 5 |
| 2024-03-15 | omnipian | Omnipian Plays The Binding of Isaac - Part 250 | 41:44 | 5 |
| 2024-03-14 | ExaggeratedElegy | Let's Play The Binding of Isaac: OBSCENE POWER. | 32:51 | 73 |
| 2024-03-13 | ExaggeratedElegy | Let's Play The Binding of Isaac: A Surprising Turn. | 52:17 | 67 |
| 2024-03-11 | Daniel Cornwall | Lets Play the Binding of Isaac Part 176(Jacobstown) | 1:32:12 | 0 |
| 2024-03-11 | Daniel Cornwall | Lets Play the Binding of Isaac Part 175(End Burrowing Enemies Now) | 1:31:10 | 1 |
| 2024-03-11 | Daniel Cornwall | Lets Play the Binding of Isaac Part 174(Giving Up The Ghost) | 1:27:49 | 1 |
| 2024-03-11 | Daniel Cornwall | Lets Play the Binding of Isaac Part 173(More Hatin On Pocket Items) | 1:42:42 | 1 |
| 2024-03-11 | omnipian | Omnipian Plays The Binding of Isaac - Part 249 | 37:55 | 6 |
| 2024-03-09 | Ephrio | Loki boss | Isaac | 0:32 | 178 |
| 2024-03-07 | omnipian | Omnipian Plays The Binding of Isaac - Part 248 | 33:10 | 11 |
| 2024-03-03 | omnipian | Omnipian Plays The Binding of Isaac - Part 247 | 45:53 | 12 |
| 2024-03-02 | Ephrio | Maggy vs Super Greed | 1:00 | 169 |
| 2024-02-28 | ExaggeratedElegy | Let's Play The Binding of Isaac: Corpse Tank. | 55:46 | 25 |
| 2024-02-28 | omnipian | Omnipian Plays The Binding of Isaac - Part 246 | 50:33 | 9 |
| 2024-02-27 | ExaggeratedElegy | Let's Play The Binding of Isaac: OVERKILL. | 57:50 | 39 |
| 2024-02-25 | ExaggeratedElegy | Let's Play The Binding of Isaac: Well, That's Weird. | 41:26 | 38 |
| 2024-02-24 | omnipian | Omnipian Plays The Binding of Isaac - Part 245 | 42:08 | 10 |
| 2024-02-24 | Ephrio | Maggy versus Pestilence | 0:37 | 52 |
| 2024-02-23 | GameJam Deutschland | Ich liebe es da es ein spannender Run wird! in The Binding of Isaac | Let's play German / Deutsch | 2:08:08 | 4 |
| 2024-02-22 | GameJam Deutschland | Ich liebe es da es ein spannender Run wird! in The Binding of Isaac | Let's play German / Deutsch | 1:55:07 | 3 |
| 2024-02-20 | omnipian | Omnipian Plays The Binding of Isaac - Part 244 | 57:50 | 2 |
| 2024-02-17 | Ephrio | Magdalene vs Envy | 0:59 | 83 |
| 2024-02-16 | omnipian | Omnipian Plays The Binding of Isaac - Part 243 | 48:18 | 6 |
| 2024-02-12 | omnipian | Omnipian Plays The Binding of Isaac - Part 242 | 47:23 | 18 |
| 2024-02-11 | Emerald Masters | Shadow plays The Binding Of Isaac! | 15:22 | 1,246 |
| 2024-02-11 | Indelacio.co.uk : Lets Plays and Game Reviews | Ziggurat Single Play Doom meets The Binding Of Isaac With Wands #ziggurat #singleplay #rotuelike | 3:29:46 | 7 |
| 2024-02-10 | LeooBruu | 👊Si me golpean cambio de juego👊 | 11:30 | 405 |
