| 1. |  Fafa Al Animation | 81,235 | ISAAC VS BF | FNF (THE BINDING OF ISAAC) | 1:08 |
| 2. | Cook Boss88 | 12,571 | CULT LEADER LAMB meets The Child from BINDING OF ISAAC (Cult of the LambxBinding of Isaac Comic dub) | 1:41 |
| 3. | Steam Deck Mania | 4,934 | CHEAP Steam Deck Games on SALE That You'll Regret Missing Out On! | 0:00 |
| 4. | CRAZYMOBILE CHANNEL | 2,814 | Winlator 3.2 - The Binding of Isaac Mali Mediatek Helio P60 | 6:06 |
| 5. | TrickyJebus | 1,655 | Boss Rush Apocalypse - Addicting and Hard! | 15:59 |
| 6. | Back2Gaming | 755 | The Binding of Isaac on Linux (Proton 3.16-3 beta) | RX 580 8GB | 8:19 |
| 7. | BloodyYellowz | 307 | Fanmade Death Battle Trailer: Isaac vs Madotsuki (The Binding of Isaac vs Yume Nikki) | 0:19 |
| 8. | Tarkus B | 102 | Binding of Isaac - Wrath of the Lamb 9 Lives Challenge | 29:46 |
| 9. | Bread | 96 | Binding of Isaac: Tainted Isaac run - Poly + Spirit Sword + Lost Contact = WIN | 27:33 |
| 10. | Shiio | 60 | [Magic : The Gathering] The Binding of Isaac and Chaos Orb - Monday Morning Magic Episode 11 | 2:30 |
| 11. | Chaozikgamer | 26 | The Endless Zombie Rampage Walkthrough part 1 | 7:21 |
| 12. | Vian Plays | 25 | Vian Plays An Addicting Indie Game | 42:17 |
| 13. | Rycopene | 18 | The Binding of Isaac | THIS GAME IS AWESOME! | 7:15 |
| 14. | Recezz | 17 | The Binding of Issac: Repentance | 0:00 |
| 15. | PLAWD | 11 | [Binding of Isaac] Duo with TuronnDraco | 2:12:20 |
| 16. | Lunacy | 7 | Eve Did It! | The Binding of Isaac Series | Lunacy Gameplay, No Commentary #LunesLunacy #Lunacy | 27:53 |
| 17. | SpankyPie | 7 | Hashtag Dungeon - First 6 Minutes | 6:11 |
| 18. | RandomHobby | 3 | Binding of Isaac - Part 2 | 17:00 |
| 19. | Gian | 3 | The Binding of Isaac #4 | 1:18:46 |
| 20. | SketchyGerry | 3 | Indie Monday Streams - The Binding of Isaac - by SketchyGerry (Pinoy) | 2:09:04 |
