| 1. |  Fafa Al Animation | ISAAC VS BF | FNF (THE BINDING OF ISAAC) | 81,235 | |
| 2. | Cook Boss88 | CULT LEADER LAMB meets The Child from BINDING OF ISAAC (Cult of the LambxBinding of Isaac Comic dub) | 12,571 | |
| 3. | CRAZYMOBILE CHANNEL | Winlator 3.2 - The Binding of Isaac Mali Mediatek Helio P60 | 2,883 | |
| 4. | Steam Deck Mania | CHEAP Steam Deck Games on SALE That You'll Regret Missing Out On! | 2,711 | |
| 5. | Steam Deck Mania | Grab 'Em Quick! 30 Epic Steam Sales You Can't Miss! | 2,223 | |
| 6. | TrickyJebus | My Duo Commentary Montage #1 | 925 | |
| 7. | Back2Gaming | The Binding of Isaac on Linux (Proton 3.16-3 beta) | RX 580 8GB | 755 | |
| 8. | Redsz | Box64droid | The Binding of Isaac Repetance | PC Game on Android | 471 | |
| 9. | TrickyJebus | Binding of Isaac wrath of the Lamb With Liam Bax- RAGE AND WHALES (2) | 381 | |
| 10. | BloodyYellowz | Fanmade Death Battle Trailer: Isaac vs Madotsuki (The Binding of Isaac vs Yume Nikki) | 307 | |
| 11. | TrickyJebus | Binding of Isaac Wrath of the Lamb with Liam Bax - BEAT YOU UP (1) | 180 | |
| 12. | TrickyJebus | Boss Rush Apocalypse - Addicting and Hard! | 128 | |
| 13. | Bread | Binding of Isaac: Tainted Isaac run - Poly + Spirit Sword + Lost Contact = WIN | 86 | |
| 14. | Shiio | [Magic : The Gathering] The Binding of Isaac and Chaos Orb - Monday Morning Magic Episode 11 | 60 | |
| 15. | Tarkus B | Binding of Isaac - Wrath of the Lamb 9 Lives Challenge | 56 | |
| 16. | TrickyJebus | The Binding of Isaac/Wrath of the Lamb-I HAVE RAGE ISSUES!(1) | 41 | |
| 17. | Tarkus B | Binding of Isaac - Wrath of the Lamb "1st attempt gameplay" Part 2 | 27 | |
| 18. | Chaozikgamer | The Endless Zombie Rampage Walkthrough part 1 | 26 | Walkthrough |
| 19. | Vian Plays | Vian Plays An Addicting Indie Game | 25 | Let's Play |
| 20. | Tarkus B | Binding of Isaac - Wrath of the Lamb "1st attempt gameplay" Part 1 | 19 | |
| 21. | Rycopene | The Binding of Isaac | THIS GAME IS AWESOME! | 18 | |
| 22. | PLAWD | [Binding of Isaac] Duo with TuronnDraco | 11 | |
| 23. | Bread | Binding of Isaac: Lost vs Mother - P A I N | 10 | |
| 24. | Recezz | The Binding of Issac: Repentance | 9 | |
| 25. | Recezz | Binding of Issac: Repentance | 8 | |
| 26. | Lunacy | Eve Did It! | The Binding of Isaac Series | Lunacy Gameplay, No Commentary #LunesLunacy #Lunacy | 7 | |
| 27. | SpankyPie | Hashtag Dungeon - First 6 Minutes | 7 | |
| 28. | SketchyGerry | Indie Monday Streams - The Binding of Isaac - by SketchyGerry (Pinoy) | 3 | |
| 29. | Treb Corner | Binding of Isaac - Part 2 | 3 | |
| 30. | Gian | The Binding of Isaac #2 | 2 | |
| 31. | Gian | The Binding of Isaac #1 | 1 | |
| 32. | Gian | The Binding of Isaac #4 | 0 | |
| 33. | Gian | The Binding of Isaac #3 | 0 | |
