| 1. |  YuB | they added my beanie to isaac!! | 2,635 | Let's Play |
| 2. | Nova | Until I Rage: The Binding Of Isaac Pt.1 - What In the World | 2,201 | Let's Play |
| 3. | Nova | Until I Rage: The Binding Of Isaac Pt.6 (END) - Flies Are Terrible | 1,754 | Let's Play |
| 4. | Nova | Until I Rage: The Binding Of Isaac Pt.4 - NOT AGAIN | 1,472 | Let's Play |
| 5. | Nova | Until I Rage: The Binding Of Isaac Pt.3 - Moms Pad....My god.. | 1,335 | Let's Play |
| 6. | Cryaotic | Cry Plays: The Binding of Crysaac [100,000] | 1,131 | Let's Play |
| 7. | Nova | Until I Rage: The Binding Of Isaac Pt.5 - YOU TROLL! | 1,114 | Let's Play |
| 8. | Nova | Until I Rage: The Binding Of Isaac Pt.2 - Fly Of Doom | 1,031 | Let's Play |
| 9. | Cryaotic | Very Sleepy Cry Plays: Binding of Isaac | 940 | Let's Play |
| 10. | YuB | isaac but it's a platforming game | 776 | Let's Play |
| 11. | YuB | attempting mega satan with the lost (live) binding of isaac | 477 | Let's Play |
| 12. | bisnap | Custom The Binding of Isaac Challenge Run 156 - The Trollpaca feat AlpacaPatrol! | 394 | Let's Play |
| 13. | bisnap | Bisnap Plays Isaac Community Remix - Part 1 | 355 | Let's Play |
| 14. | green9090 | Let's Play Wrath of the Lamb ep 30, Most. Overpowered. Run. Ever. | 336 | Let's Play |
| 15. | bisnap | Bisnap Plays Isaac Community Remix - Part 6 | 288 | Let's Play |
| 16. | bisnap | Let's Play The Binding of Isaac Episode 1 - A Fresh Start | 249 | Let's Play |
| 17. | green9090 | Let's Play Binding of Isaac Unholy Edition ep 162, Version 1.5! | 235 | Let's Play |
| 18. | green9090 | Let's Play Wrath of the Lamb ep 57, A New "Most Overpowered Run Ever"? | 228 | Let's Play |
| 19. | green9090 | Let's Play Wrath of the Lamb ep 120, War Blimp [Custom Challenge Run #42] | 207 | Let's Play |
| 20. | green9090 | Let's Play Wrath of the Lamb ep 122, Necromancer [Custom Challenge Run #44] | 189 | Let's Play |
| 21. | bisnap | The Binding of Isaac Episode 143 - Willpower | 187 | Let's Play |
| 22. | green9090 | Let's Play Wrath of the Lamb ep 145, Whose Line is it Anyway? w/ Alpaca, Austin, and Cam! | 183 | Let's Play |
| 23. | NicoB | SO MUCH GAME! - Let's Play - Video Game: The Game - Complete Walkthrough Playthrough | 181 | Let's Play |
| 24. | bisnap | The Binding of Isaac Episode 135 - A Nice Chat feat. AlpacaPatrol! | 172 | Let's Play |
| 25. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 90 - Cain Is Back | 172 | Let's Play |
| 26. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 50 - Isaac Vs ??? | 172 | Let's Play |
| 27. | green9090 | Let's Play Binding of Isaac Unholy Edition ep 165, All Familiar Run! | 166 | Let's Play |
| 28. | green9090 | Let's Play Wrath of the Lamb ep 156, Justified Ego [Custom Challenge Run #60] | 149 | Let's Play |
| 29. | green9090 | Let's Play Wrath of the Lamb ep 123, Cyclops [Custom Challenge Run #45] | 149 | Let's Play |
| 30. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 148 - Just Watch This One | 148 | Let's Play |
| 31. | green9090 | Let's Play Wrath of the Lamb ep 161, ValenTINES [Custom Challenge Run #65] | 145 | Let's Play |
| 32. | green9090 | Let's Play Wrath of the Lamb ep 126, Upside Down [Custom Challenge Run #48] | 143 | Let's Play |
| 33. | green9090 | Let's Play Wrath of the Lamb ep 116, Halloween Costume! [Custom Challenge Run #38] | 142 | Let's Play |
| 34. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 38 - Being Guppy | 138 | Let's Play |
| 35. | green9090 | Let's Play The Binding of Isaac ep 146, Dice Again! w/ Zen, Alpaca, Austin, and Cam! | 133 | Let's Play |
| 36. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 108 - Luck Up! | 128 | Let's Play |
| 37. | green9090 | The Binding of Isaac Head to Head ep 23, Guest Starring AlpacaPatrol! | 126 | Let's Play |
| 38. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 29 - Samson Vs Isaac 3 | 123 | Let's Play |
| 39. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 58 - Cain Vs ??? | 123 | Let's Play |
| 40. | green9090 | Let's Play Wrath of the Lamb ep 160, Health = Power [Custom Challenge Run #64] | 123 | Let's Play |
| 41. | green9090 | Let's Play Wrath of the Lamb ep 115, Heat Seekers [Custom Challenge Run #37] | 123 | Let's Play |
| 42. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 61 - Judas Vs ??? | 122 | Let's Play |
| 43. | green9090 | Let's Play Wrath of the Lamb ep 140, Shit, Let's Be Santa! [Custom Challenge Run #58] | 121 | Let's Play |
| 44. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 93 - Bloody Penny Trick | 120 | Let's Play |
| 45. | green9090 | Let's Play Wrath of the Lamb ep 118, Headless Horseman [Custom Challenge Run #40] | 119 | Let's Play |
| 46. | ZackScottGames | The Binding of Isaac - Wrath of the Lamb - Part 32 - Judas Vs Isaac | 118 | Let's Play |
| 47. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 86 - So Close! | 117 | Let's Play |
| 48. | bisnap | Bisnap Plays Isaac Community Remix - Part 2 | 116 | Let's Play |
| 49. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 89 - No Item Attempt | 114 | Let's Play |
| 50. | bisnap | Bisnap Plays Isaac Community Remix - Part 3 | 113 | Let's Play |
| 51. | green9090 | Let's Play The Binding of Isaac ep 142, Stompfest | 111 | Let's Play |
| 52. | green9090 | Let's Play Wrath of the Lamb ep 117, An Offensive Smell [Custom Challenge Run #39] | 111 | Let's Play |
| 53. | green9090 | Let's Play Wrath of the Lamb ep 119, Tooth Fairy [Custom Challenge Run #41] | 110 | Let's Play |
| 54. | bisnap | Bisnap Plays Isaac Community Remix - Part 5 | 109 | Let's Play |
| 55. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 74 - Samson Vs ??? | 108 | Let's Play |
| 56. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 39 - Eve Vs Isaac | 107 | Let's Play |
| 57. | green9090 | Let's Play The Binding of Isaac ep 141, Drinking Game | 106 | Let's Play |
| 58. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 71 - ???'s Soul | 106 | Let's Play |
| 59. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 76 - A Religious Question Mark | 106 | Let's Play |
| 60. | ster 2 | Binding of Isaac [03] The Worst Playthrough | 106 | Let's Play |
| 61. | green9090 | Let's Play Wrath of the Lamb ep 114, Normal Run | 102 | Let's Play |
| 62. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 30 - Magdalene VS Isaac | 101 | Let's Play |
| 63. | bisnap | Let's Play The Binding of Isaac Episode 116 - Screw You, Speed Ball! [Finale] | 101 | Let's Play |
| 64. | Wolv21 | The Binding of Isaac w/ Wolv21 - Wrath of the Lamb - Ep 159 - Random (Epic Run) | 101 | Let's Play |
| 65. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 84 - Error to Satan | 100 | Let's Play |
| 66. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 87 - Must Reroll! | 99 | Let's Play |
| 67. | green9090 | Let's Play Wrath of the Lamb ep 139, Never Look Back [Custom Challenge Run #57] | 99 | Let's Play |
| 68. | bisnap | Let's Play The Binding of Isaac Episode 103 - My Most Overpowered Run Ever? | 98 | Let's Play |
| 69. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 28 - Three Girls Playing Diablo III | 98 | Let's Play |
| 70. | green9090 | Let's Play Binding of Isaac Unholy Edition ep 164, Blast It With Piss! [Custom Challenge #67] | 97 | Let's Play |
| 71. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 41 - Wrong Path! | 94 | Let's Play |
| 72. | green9090 | Let's Play Binding of Isaac Unholy Edition ep 163, Moving Day [Custom Challenge #66] | 93 | Let's Play |
| 73. | green9090 | Let's Play Wrath of the Lamb ep 94, Baller [Custom Challenge Run #18] | 93 | Let's Play |
| 74. | green9090 | Let's Play Wrath of the Lamb ep 102, Blinded By The Comments [Custom Challenge Run #25] | 92 | Let's Play |
| 75. | green9090 | Let's Play Wrath of the Lamb ep 154, Isaac Was OP Today [Challenge #9] | 92 | Let's Play |
| 76. | green9090 | Let's Play Wrath of the Lamb ep 121, Monstro's Tooth Remedial Course [Custom Challenge Run #43] | 92 | Let's Play |
| 77. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 67 - Eve Vs ??? | 91 | Let's Play |
| 78. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 79 - Spelunker Boy | 90 | Let's Play |
| 79. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 43 - Eve Vs Isaac 2 | 89 | Let's Play |
| 80. | green9090 | Let's Play Wrath of the Lamb ep 144, Madness With Austin [Custom Challenge Run #59] | 89 | Let's Play |
| 81. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 27 - A Heart and a Head | 88 | Let's Play |
| 82. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 143 - Poison Laser | 88 | Let's Play |
| 83. | bisnap | Bisnap Plays Isaac Community Remix - Part 8 | 88 | Let's Play |
| 84. | bisnap | Let's Play The Binding of Isaac Episode 2 - Nine Lives | 87 | Let's Play |
| 85. | green9090 | Let's Play Wrath of the Lamb ep 110, Shotgun [Custom Challenge Run #33] | 87 | Let's Play |
| 86. | bisnap | Bisnap Plays Isaac Community Remix - Part 7 | 86 | Let's Play |
| 87. | green9090 | Let's Play Wrath of the Lamb ep 143, Drunk Was The Night [Challenge Run #1] | 86 | Let's Play |
| 88. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 96 - Big with the Bombs Again | 86 | Let's Play |
| 89. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 66 - Samson Vs Satan | 85 | Let's Play |
| 90. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 92 - I Was Doing So Well... | 85 | Let's Play |
| 91. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 81 - Calling Dr. Isaac | 85 | Let's Play |
| 92. | Cryaotic | Cry Plays: Gish | 85 | Let's Play |
| 93. | green9090 | Let's Play Wrath of the Lamb ep 158, Boss Rush [Custom Challenge Run #62] | 84 | Let's Play |
| 94. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 101 - Hairball | 84 | Let's Play |
| 95. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 65 - Dad's Key | 83 | Let's Play |
| 96. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 34 - Fourth Time's a Charm | 83 | Let's Play |
| 97. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 132 - I Did Not Realize Shears Did This | 83 | Let's Play |
| 98. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 56 - Samson Vs Satan | 82 | Let's Play |
| 99. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 45 - ??? Vs Isaac | 82 | Let's Play |
| 100. | green9090 | Let's Play Wrath of the Lamb ep 113, Telepain [Custom Challenge Run #36] | 81 | Let's Play |
