| 1. |  YuB | they added my beanie to isaac!! | 10,683 | Let's Play |
| 2. | Nova | Until I Rage: The Binding Of Isaac Pt.1 - What In the World | 6,844 | Let's Play |
| 3. | Cryaotic | Cry Plays: The Binding of Crysaac [100,000] | 5,476 | Let's Play |
| 4. | Cryaotic | Very Sleepy Cry Plays: Binding of Isaac | 5,290 | Let's Play |
| 5. | Nova | Until I Rage: The Binding Of Isaac Pt.6 (END) - Flies Are Terrible | 4,982 | Let's Play |
| 6. | YuB | attempting mega satan with the lost (live) binding of isaac | 4,912 | Let's Play |
| 7. | YuB | isaac but it's a platforming game | 4,551 | Let's Play |
| 8. | Nova | Until I Rage: The Binding Of Isaac Pt.4 - NOT AGAIN | 3,996 | Let's Play |
| 9. | Nova | Until I Rage: The Binding Of Isaac Pt.3 - Moms Pad....My god.. | 3,961 | Let's Play |
| 10. | Nova | Until I Rage: The Binding Of Isaac Pt.2 - Fly Of Doom | 3,875 | Let's Play |
| 11. | Nova | Until I Rage: The Binding Of Isaac Pt.5 - YOU TROLL! | 3,756 | Let's Play |
| 12. | bisnap | Bisnap Plays Isaac Community Remix - Part 1 | 1,374 | Let's Play |
| 13. | bisnap | Let's Play The Binding of Isaac Episode 1 - A Fresh Start | 1,241 | Let's Play |
| 14. | bisnap | Bisnap Plays Isaac Community Remix - Part 6 | 1,206 | Let's Play |
| 15. | NicoB | SO MUCH GAME! - Let's Play - Video Game: The Game - Complete Walkthrough Playthrough | 896 | Let's Play |
| 16. | green9090 | Let's Play Wrath of the Lamb ep 30, Most. Overpowered. Run. Ever. | 850 | Let's Play |
| 17. | Cryaotic | Cry Plays: Gish | 764 | Let's Play |
| 18. | green9090 | Let's Play Wrath of the Lamb ep 57, A New "Most Overpowered Run Ever"? | 749 | Let's Play |
| 19. | bisnap | Bisnap Plays Isaac Community Remix - Part 2 | 710 | Let's Play |
| 20. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 78 - ??? Vs ??? 2 | 686 | Let's Play |
| 21. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 148 - Just Watch This One | 633 | Let's Play |
| 22. | bisnap | Bisnap Plays Isaac Community Remix - Part 3 | 628 | Let's Play |
| 23. | bisnap | Let's Play The Binding of Isaac Episode 103 - My Most Overpowered Run Ever? | 614 | Let's Play |
| 24. | bisnap | Let's Play The Binding of Isaac Episode 2 - Nine Lives | 613 | Let's Play |
| 25. | ZackScottGames | The Binding of Isaac - Wrath of the Lamb - Part 32 - Judas Vs Isaac | 578 | Let's Play |
| 26. | green9090 | Let's Play Binding of Isaac Unholy Edition ep 162, Version 1.5! | 577 | Let's Play |
| 27. | bisnap | Custom The Binding of Isaac Challenge Run 156 - The Trollpaca feat AlpacaPatrol! | 558 | Let's Play |
| 28. | bisnap | Bisnap Plays Isaac Community Remix - Part 5 | 537 | Let's Play |
| 29. | ster 2 | Binding of Isaac [03] The Worst Playthrough | 522 | Let's Play |
| 30. | bisnap | Bisnap Plays Isaac Community Remix - Part 8 | 481 | Let's Play |
| 31. | bisnap | Bisnap Plays Isaac Community Remix - Part 7 | 424 | Let's Play |
| 32. | green9090 | Let's Play Wrath of the Lamb ep 145, Whose Line is it Anyway? w/ Alpaca, Austin, and Cam! | 392 | Let's Play |
| 33. | green9090 | Let's Play Wrath of the Lamb ep 120, War Blimp [Custom Challenge Run #42] | 387 | Let's Play |
| 34. | bisnap | Let's Play The Binding of Isaac Episode 4 - Judas | 381 | Let's Play |
| 35. | Wolv21 | The Binding of Isaac w/ Wolv21 - EPIC WIN | Maggie vs. Isaac | 371 | Let's Play |
| 36. | bisnap | Bisnap Plays Isaac Community Remix - Part 9 | 370 | Let's Play |
| 37. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 50 - Isaac Vs ??? | 359 | Let's Play |
| 38. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 38 - Being Guppy | 357 | Let's Play |
| 39. | bisnap | Let's Play The Binding of Isaac Episode 31 - Epic Fetus + Bonus Surprise | 351 | Let's Play |
| 40. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 143 - Poison Laser | 348 | Let's Play |
| 41. | green9090 | The Binding of Isaac Head to Head ep 23, Guest Starring AlpacaPatrol! | 348 | Let's Play |
| 42. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 30 - Magdalene VS Isaac | 347 | Let's Play |
| 43. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 45 - ??? Vs Isaac | 342 | Let's Play |
| 44. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 61 - Judas Vs ??? | 341 | Let's Play |
| 45. | bisnap | Let's Play The Binding of Isaac Episode 79 - Overkill, Much? | 330 | Let's Play |
| 46. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 74 - Samson Vs ??? | 325 | Let's Play |
| 47. | green9090 | Let's Play Wrath of the Lamb ep 156, Justified Ego [Custom Challenge Run #60] | 317 | Let's Play |
| 48. | Wolv21 | The Binding of Isaac w/ Wolv21 - Wrath of the Lamb - Ep 159 - Random (Epic Run) | 317 | Let's Play |
| 49. | green9090 | Let's Play The Binding of Isaac ep 146, Dice Again! w/ Zen, Alpaca, Austin, and Cam! | 304 | Let's Play |
| 50. | green9090 | Let's Play Wrath of the Lamb ep 137, Judgment's Son | 302 | Let's Play |
| 51. | Retromation | THE BINDING OF ISAAC TABLETOP CARD GAME!! | Binding of Isaac: Four Souls | ft. The Wholesomeverse | 299 | Let's Play |
| 52. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 58 - Cain Vs ??? | 291 | Let's Play |
| 53. | bisnap | Let's Play The Binding of Isaac Episode 7 - Enter-Cain-Ment | 290 | Let's Play |
| 54. | bisnap | Let's Play The Binding of Isaac Episode 8 - The Long Haul | 289 | Let's Play |
| 55. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 29 - Samson Vs Isaac 3 | 289 | Let's Play |
| 56. | bisnap | Let's Play The Binding of Isaac Episode 11 - A Good Samson Run? | 288 | Let's Play |
| 57. | green9090 | Let's Play Wrath of the Lamb ep 123, Cyclops [Custom Challenge Run #45] | 284 | Let's Play |
| 58. | bisnap | Let's Play The Binding of Isaac Episode 6 - Eve | 282 | Let's Play |
| 59. | green9090 | Let's Play The Binding of Isaac ep 141, Drinking Game | 281 | Let's Play |
| 60. | green9090 | Let's Play Binding of Isaac Unholy Edition ep 165, All Familiar Run! | 280 | Let's Play |
| 61. | Table | Table Plays - The New and Improved "Protein Pirates!" or, Enzyme Embezzlement | 279 | Let's Play |
| 62. | bisnap | The Binding of Isaac Episode 143 - Willpower | 269 | Let's Play |
| 63. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 43 - Eve Vs Isaac 2 | 269 | Let's Play |
| 64. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 56 - Samson Vs Satan | 268 | Let's Play |
| 65. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 66 - Samson Vs Satan | 266 | Let's Play |
| 66. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 79 - Spelunker Boy | 264 | Let's Play |
| 67. | green9090 | Let's Play Wrath of the Lamb ep 144, Madness With Austin [Custom Challenge Run #59] | 264 | Let's Play |
| 68. | green9090 | Let's Play Wrath of the Lamb ep 116, Halloween Costume! [Custom Challenge Run #38] | 262 | Let's Play |
| 69. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 31 - Heavy on the Soul Hearts | 259 | Let's Play |
| 70. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 85 - Blood Rights | 259 | Let's Play |
| 71. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 67 - Eve Vs ??? | 253 | Let's Play |
| 72. | bisnap | Let's Play The Binding of Isaac Episode 80 - Sacred Heart | 253 | Let's Play |
| 73. | bisnap | Let's Play The Binding of Isaac Episode 116 - Screw You, Speed Ball! [Finale] | 253 | Let's Play |
| 74. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 76 - A Religious Question Mark | 253 | Let's Play |
| 75. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 94 - A Boom in Progress | 252 | Let's Play |
| 76. | green9090 | Let's Play Wrath of the Lamb ep 160, Health = Power [Custom Challenge Run #64] | 251 | Let's Play |
| 77. | TimDotTV | BINDING OF ISAAC WITH GUNS?! | Compound Alpha (HTC Vive Gameplay) | 248 | Let's Play |
| 78. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 41 - Wrong Path! | 247 | Let's Play |
| 79. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 27 - A Heart and a Head | 246 | Let's Play |
| 80. | bisnap | Let's Play The Binding of Isaac Episode 15 - Way Overpowered | 246 | Let's Play |
| 81. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 93 - Bloody Penny Trick | 244 | Let's Play |
| 82. | green9090 | Let's Play Wrath of the Lamb ep 154, Isaac Was OP Today [Challenge #9] | 244 | Let's Play |
| 83. | bisnap | The Binding of Isaac Episode 135 - A Nice Chat feat. AlpacaPatrol! | 243 | Let's Play |
| 84. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 75 - ??? Vs ??? | 243 | Let's Play |
| 85. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 108 - Luck Up! | 242 | Let's Play |
| 86. | bisnap | Let's Play The Binding of Isaac Episode 9 - Maggy's Turn | 240 | Let's Play |
| 87. | bisnap | Let's Play The Binding of Isaac Episode 18 - The D6 | 240 | Let's Play |
| 88. | Yippee Ki Yay Mr Falcon | Let's Play 60 Seconds - Part 15 - Binding of Isaac Challenge (60 Seconds Gameplay) | 238 | Let's Play |
| 89. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 63 - A Horrible Night in the Cathedral | 236 | Let's Play |
| 90. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 90 - Cain Is Back | 235 | Let's Play |
| 91. | Olexa | BINDING OF ISAAC TRIVIA?! | Sporcle Quizzes with @orbitalpotato | 234 | Let's Play |
| 92. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 98 - Blood for Halos | 232 | Let's Play |
| 93. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 39 - Eve Vs Isaac | 227 | Let's Play |
| 94. | Wolv21 | The Binding of Isaac w/ Wolv21 - Wrath of the Lamb - Ep 160 - Cain (Epic Run) | 227 | Let's Play |
| 95. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 34 - Fourth Time's a Charm | 226 | Let's Play |
| 96. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 36 - Blue Candle | 224 | Let's Play |
| 97. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 62 - D20 | 223 | Let's Play |
| 98. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 142 - No Damage??? | 222 | Let's Play |
| 99. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 64 - Sacrificial Dagger | 222 | Let's Play |
| 100. | ZackScottGames | The Binding of Isaac: Wrath of the Lamb - Part 59 - Magdalene Vs ??? | 221 | Let's Play |
