| 1. |  El Gamer Friki | Top 5 Misterios en Videojuegos que Esconden o Escondieron un Gran Secreto | 985 | |
| 2. | Skinybanana | The binding of Isaac: Top 10 peores items | 899 | |
| 3. | Grunguiestooth | How to Unlock The Forgotten | The Binding Of Isaac: Afterbirth + The Forgotten Update! | 862 | Vlog |
| 4. | levelup.com | Bits: Los juegos difíciles también son para casuales | 635 | |
| 5. | Holtromen | TierList de Desbloqueos - ¿En que personaje enfocarse? | The binding of isaac REPENTANCE | 541 | |
| 6. | Vico Mico | ISAAC DANCE MOD - The Binding of Isaac: Repentance | 482 | |
| 7. | Lukii Moi | Isaac Afterbirth Plus - Lukii vs IL (Reskin Mod INNER END). | 471 | |
| 8. | Skinybanana | Top 10 mejores items: The binding of Isaac Repentance | 449 | |
| 9. | Lukii Moi | Isaac Afterbirth Plus - Insanity (Terminal Phase) [Delirium Reskin Mod + Full INNER END walkthrough] | 446 | |
| 10. | Grunguiestooth | TBoI: Afterbirth "Perfect Seed (OP Seeds)" [Ep.46] | 408 | |
| 11. | PXTU | Como desbloquear TODOS los personajes y tainted tambien :D | Binding of isaac repentance GUIA #1 | 400 | |
| 12. | Vico Mico | BUMBINO PACIFIST Secret Easter Egg - The Binding of Isaac: Repentance [DOUBLE ITEM] | 358 | |
| 13. | Soy Jeruk | DESENCRIPTA JUEGOS de SWITCH .XCI para EMULADORES YUZU y RYUJINX + Descarga | 339 | |
| 14. | Wirtyom | Los Tipos de jugadores en el Isaac ༼ つ ◕_◕ ༽つ | 338 | |
| 15. | ChuyMine R | The Binding of Isaac PERO el CHAT tiene el CONTROL | 337 | |
| 16. | Grunguiestooth | TBoI: Afterbirth "Judas Proptosis + Incubus 1st Floor" [Ep.17] | 335 | |
| 17. | Wirtyom | Top 15 Peores Activas en el Isaac (TBOIR)👀👎(o no las más óptimas) | 301 | |
| 18. | Lukii Moi | Isaac Afterbirth Plus - His Eye (Reskin Mod INNER END ❥) | 292 | |
| 19. | Grunguiestooth | TBoI: Afterbirth "Keeper Vs Mom,Boss Rush,It Lives !,Hush,Isaac,???,Mega Satan" [Ep.06] | 290 | |
| 20. | ALK4PON3 | Me gusta la Flagelación | The Binding of Isaac Rebirth | 285 | |
| 21. | Master Combo | 💥 VER DESCRIPCIONES ITEMS 💥 - MOD TBOI Repentance | Afterbirth Plus | External Item Descriptions | 276 | |
| 22. | ChuyMine R | MI PRIMERA VEZ en Binding of Isaac Termino muy mal 😭 | 273 | |
| 23. | Grunguiestooth | THE FORGOTTEN VS ISAAC, ??? & MEGA SATAN | 260 | |
| 24. | Lukii Moi | Isaac Afterbirth Plus - Lukii vs IL VERSION 2 (Reskin Mod INNER END) | 260 | |
| 25. | Wirtyom | La Historia de Isaac Hasta Repentance (Explicación último final) | 259 | |
| 26. | Wirtyom | Errores de los novatos en Isaac | 242 | |
| 27. | Vico Mico | 5 MODS for Tainted characters - The Binding of Isaac: Repentance | 228 | |
| 28. | Master Combo | ✅ PROBLEMAS con el MOD VER las DESCRIPCIONES de los ITEMS ❓ - The Binding of Isaac Repentance 🚀 | 222 | |
| 29. | Lukii Moi | Isaac Afterbirth Plus - Infested Soul (Reskin Mod INNER END ❥) | 218 | |
| 30. | Lukii Moi | Isaac Afterbirth Plus - Lukii vs Malicious Coles (Reskin Mod INNER END) | 215 | |
| 31. | Esaups | Top 5 Juegos Roguelike Pixelados pocos requisitos | 212 | |
| 32. | Wirtyom | Significado de: Azazel y su Alterno (Tainted) TboiR | 211 | |
| 33. | Demaeter | Juguemos Binding of Isaac - 80 - El mejor objeto del juego - Final | 209 | |
| 34. | Wirtyom | El significado de Jacob & Esau y Alternos (Tainted) Tboi | 207 | |
| 35. | ZokaRed VT | Los JEFES ahora son WAIFUS | The Binding Of Isaac Repentance En Español | 207 | |
| 36. | Grunguiestooth | TBoI: Afterbirth "The best RUN with The Lost" [Ep.72] | 205 | |
| 37. | ALK4PON3 | Survivers vs Mountruos | Shout Survival con el TeamGG | 205 | |
| 38. | Lukii Moi | Isaac Afterbirth Plus - Lukii vs PO-NY (❥ INNER END Reskin Mod) | 205 | |
| 39. | levelup.com | Bits: El ataque de las secuelas | 203 | |
| 40. | Riserbeck | The Binding Of Isaac Afterbirth EP01 Riser Vs MOM | 202 | |
| 41. | Lukii Moi | Isaac Afterbirth Plus - Lukii vs Daddy's Demon (Reskin Mod INNER END) | 196 | |
| 42. | Demaeter | Guía Tutorial: como acelerar Binding of Isaac Rebirth en PCs antiguas. | 195 | Tutorial |
| 43. | Wirtyom | 🔮⭐¿Cuál es el mejor Planetario? ⭐🔮 (TBOI Repentance) | 190 | |
| 44. | Lukii Moi | Isaac Afterbirth Plus - Special Flower (Reskin Mod INNER END ❥) | 187 | |
| 45. | Grunguiestooth | TBoI: Afterbirth "Mega blast OP" [Ep.27] | 184 | |
| 46. | Lukii Moi | Isaac Afterbirth Plus - Overprotective (Reskin Mod INNER END ❥) | 180 | |
| 47. | Demaeter | Juguemos The Binding of Saludos - YOLO - Pide saludos aquí! | 179 | |
| 48. | Grunguiestooth | TBoI: Afterbirth "AMAZING Run With Only 3 Items" [Ep.57] | 173 | |
| 49. | Grunguiestooth | + 6000 DMG | INSTA KILL DEILIRIUM | AN EPIC RUN FOR AN EPIC DAY! | MY BIRTHDAY! | 169 | |
| 50. | Cultura VJ | Top 10 Juegos cooperativos (PC) | 168 | |
| 51. | Vico Mico | Characters that were previously Mods - The Binding of Isaac: Repentance | 167 | |
| 52. | Vico Mico | Mei Tainted Update - The Binding of Isaac: Repentance [Mod] | 167 | Vlog |
| 53. | Lukii Moi | Isaac Afterbirth Plus - Lollipop Bunny (Reskin Mod INNER END ❥) | 164 | |
| 54. | Grunguiestooth | TBoI: Afterbirth "Win Streak 100 | OP Seed (Breaking Run)" [Ep.28] | 163 | |
| 55. | TiranoSE | THE BINDING OF ISAAC REPENTANCE - COMO DESBLOQUEAR A THE LOST | 157 | |
| 56. | Wirtyom | ¿Que significan los personajes Alternativos en Isaac? | 152 | |
| 57. | Wirtyom | El Significado de: Samson. (y su Alterno) The Binding Of Isaac Repentance. | 151 | |
| 58. | Lukii Moi | Isaac Afterbirth Plus - Sadness Clot (Reskin Mod INNER END ❥) | 149 | |
| 59. | Grunguiestooth | TBoI: Afterbirth " Funny Seed With LILITH " [Ep.34] | 147 | |
| 60. | Wirtyom | El SIgnificado de: Judas y su Alterno | 146 | |
| 61. | Grunguiestooth | TBoI: Afterbirth+ "The Lost VS DELIRIUM" [Ep.05] | 144 | |
| 62. | Master Combo | MOD ver las DESCRIPCION de los ITEMS ▶ Isaac Repentance | 144 | |
| 63. | Demaeter | Juguemos The Binding of Saludos - Cuchillo OP - Demasiados Saludos | 144 | |
| 64. | Kirigaza | Romper modo greed y conseguir todos los items | The binding of isaac afterbirth+ | 144 | |
| 65. | Wirtyom | El Significado de: Apollyon y su Alterno (Tainted) TboiR | 143 | |
| 66. | Grunguiestooth | TBoI: Antibirth MOD " The Lost VS The Witness " [Ep.04] | 142 | |
| 67. | Sujes | RAINBOW FRIENDS - Catbee & Player Vs Blue | 140 | |
| 68. | Grunguiestooth | TBoI: Afterbirth "Polyphemus + Double Godhead Keeper" [Ep.19] | 139 | |
| 69. | Demaeter | Juguemos Binding of Isaac - 68 - Regreso del Bebe Gigante | 136 | |
| 70. | Demaeter | Juguemos Binding of Isaac - 25 - Toda la familia | 136 | |
| 71. | Ubaman Gameplays | PROBANDO AZAZEL EN The Binding of Isaac | 136 | |
| 72. | Grunguiestooth | TBoI: Afterbirth "The Lost, Black Market Glitch x2" [Ep.16] | 135 | |
| 73. | Grunguiestooth | TBoI: Afterbirth "Be OP Before Begin" [Ep.52] | 134 | |
| 74. | Ubaman Gameplays | UNA RUN CON CAIN Y BRIMSTONE | Isaac Afterbirth Plus | 134 | |
| 75. | Wirtyom | Top 15 mejores Activas en TBOI | 133 | |
| 76. | Lukii Moi | Isaac Afterbirth Plus - Lukii vs The Jester (Reskin Mod INNER END) | 133 | |
| 77. | Riserbeck | The Binding of Isaac: Rebirth Gameplay | 132 | |
| 78. | Demaeter | The Binding of Isaac: Rebirth - Gameplay Cooperativo en Español ! | 132 | |
| 79. | Demaeter | Juguemos Binding of Isaac - 70 - La pequeña inofensiva Eve | 130 | |
| 80. | Ubaman Gameplays | HABLANDO DEL CANAL Y JUGANDO ISAAC AFTERBIRTH | 130 | |
| 81. | Vico Mico | Job (Character with Tainted Version) - The Binding of Isaac: Repentance [Mod] | 129 | |
| 82. | Grunguiestooth | TBoI: Afterbirth "SACRED HEART & GODHEAD Same RUN" [Ep.18] | 128 | |
| 83. | Grunguiestooth | TBoI: Afterbirth " Brimstone x2 x3 x3 " [Ep.36] | 127 | |
| 84. | Grunguiestooth | THE FORGOTTEN VS GREEDIER! | 126 | |
| 85. | Ubaman Gameplays | ESTE JUEGO ES CONFUSO - The Binding of Isaac - EP 02 | 126 | |
| 86. | Lukii Moi | Isaac Afterbirth Plus - Lukii vs Techy (Reskin Mod INNER END) | 125 | |
| 87. | Espongado | HISTORIA ESPONJOSA #20 - UNIVERSIDAD | 125 | |
| 88. | Lukii Moi | Isaac Afterbirth Plus - Bitter Chick (Reskin Mod INNER END ❥) | 122 | |
| 89. | Grunguiestooth | TBoI: Afterbirth "Black Judas [BR]" [Ep.60] | 122 | |
| 90. | Vico Mico | Best MODS of the Week - The Binding of Isaac: Repentance # 2 | 122 | |
| 91. | ZokaRed VT | AHORA los TAINTED tienen TAINTEDS | ¿TAINTEDS MEJORADOS? | THE BINDING OF ISAAC REPENTANCE PLUS | 121 | |
| 92. | Wirtyom | TBOI Repentance - El significado y curiosidades de Lilith | 121 | |
| 93. | Ubaman Gameplays | PRIMERA VEZ JUGANDO ISAAC AFTERBIRTH | 121 | |
| 94. | Ubaman Gameplays | MI PRIMERA VICTORIA? The Binding of Isaac | 120 | |
| 95. | Vico Mico | ASH CAMEO Secret Easter Egg - The Binding of Isaac: Repentance [The End is Nigh] | 118 | |
| 96. | Ubaman Gameplays | MI PRIMERA VEZ EN THE BINDING OF ISAAC REBIRTH | 117 | |
| 97. | Wirtyom | El significado de: The Forgotten y Alterno (Tainted) | 117 | |
| 98. | Lukii Moi | Isaac Afterbirth Plus - Lukii vs Occult Raven (Reskin Mod INNER END) | 116 | |
| 99. | Vico Mico | Edith Tainted Update - The Binding of Isaac: Repentance [Mod] | 116 | Vlog |
| 100. | Wirtyom | Datos Que te podrían garantizar una partida. (Tboi) | 115 | |
