| 1. |  Afflux | Tutorial: How to Get The Binding of Isaac Rebirth for Mac (HD) | 245 | Tutorial |
| 2. | Alley Source | How to import data from Isaac Rebirth to Afterbirth | 74 | Tutorial |
| 3. | Lumpkin | How this DLC saved Isaac | The Binding of Isaac: Repentance | 40 | |
| 4. | Lolight | Soy Milk + C Section Is Busted... 🥛 | Binding of Isaac Repentance | 32 | |
| 5. | Lumpkin | very epic roguelike - Wally and the Fantastic Predators | 28 | |
| 6. | kier7kier7 Clips | A typical kier7kier7 stream is approaching | 22 | |
| 7. | Rurikhan | Delver's Drop - Preview [Alpha] | 21 | Let's Play |
| 8. | Alley Source | Isaac the Ninja God | 12 | |
| 9. | Bocherz | That Eternal D6 feeling #thebindingofisaac #lost #eternald6 #gamble | 11 | |
| 10. | ADuBiuS | O que estou eu a fazer? xD #1 - The Binding of Isaac: Rebirth Livestream | 10 | |
| 11. | Vazkii | The Binding of Isaac Afterbirth+: Vazkii's Item Pack | 10 | |
| 12. | Gabriel josé Fernando | REAGINDO AO @MaiconKuster YOUTUBERS Q PROVAVELMENTE FUMAM MACONHA | 9 | |
| 13. | iFailFlash | LILITH = BROKEN - The Binding of Isaac: Repentance (Greed Mode) | 8 | |
| 14. | Samurai | Como não fazer uma 1ª Run - The Binding of Isaac: Repentance | 8 | |
| 15. | ADuBiuS | Explosão nuclear de rage a caminho! #2 - The Binding of Isaac: Rebirth Livestream | 8 | |
| 16. | Fante | greed butt pad | 7 | |
| 17. | 2Manos Gamers | TOP 5 Melhores jogos INDIE (1-4 Jogadores) | 7 | |
| 18. | OVitorVieira | Isto é: Binding Of Isaac: Rebirth | 7 | |
| 19. | Bocherz | Sometimes You gotta pull a Messi in Binding of Isaac #twitch #twitchstreamer | 7 | |
| 20. | 2Manos Gamers | Quando fazes um podcast PRA ESCOLA sobre um jogo... | 6 | Show |
| 21. | Tiops | Mineirinho Ultra Adventures E The Binding of Isaac Rebirth Porque Mineirinho Travou (10/10/2017) | 5 | |
| 22. | iFailFlash | O CHALLENGE DO PUNCHING BAG - The Binding of Isaac: Repentance | 4 | |
| 23. | BIJUGAMES | The Binding of Isaac Rebirth - Full Game Windows PC DVD | 4 | |
| 24. | EurogamerPortugal | The Binding of Isaac Rebirth - 10 minutos de tormentas (gameplay) | 3 | |
| 25. | Fante | [WIP] 8-bit Binding of Isaac Trailer | 3 | Preview |
| 26. | Samurai | Primeira Run de Lazarus! - The Binding of Isaac: Repentance | 2 | |
| 27. | Metzli | The Binding of Isaac: Rebirth - PLAYING WITH BOYFRIEND | 2 | |
| 28. | Fante | [Nutshell] TBoI: Bloat Mode | 2 | |
| 29. | OVitorVieira | Lazarus Vs Dingle! Binding Of Isaac Rebirth #2 | 2 | |
| 30. | Samurai | Conseguimos derrotar a Mom!! - The Binding of Isaac: Repentance | 2 | |
| 31. | DIX | 700 inscritos :) | 2 | |
| 32. | Salsa Games | Saiu e Você Não Viu? - Binding of Isaac Rebirth | 2 | |
| 33. | Metzli | The Binding of Isaac: Rebirth - CUTE POOP OF DEATH | 2 | |
| 34. | Fante | binding of isaac file dump | 2 | |
| 35. | Samurai | #shorts O que é Binding of Isaac? | 2 | |
| 36. | Samurai | Bethany é sinónimo de Vitória - The Binding of Isaac: Repetance | 2 | |
| 37. | Macakz | Learning How To Survive In The Isaac's Mom's Basement! - The Binding of Isaac gameplay | 1 | Guide |
| 38. | Bocherz | You just have to ask nicely #thebindingofisaac #repentance #thelost #twitchstreamer #brimstone | 1 | |
| 39. | Bocherz | I can't see ANYTHING ! | 1 | |
| 40. | johnluis 76 | The Binding of Isaac:Rebirth | 1 | |
| 41. | OVitorVieira | Tantos Items! Binding Of Isaac Rebirth #4 | 1 | |
| 42. | Fante | [Nutshell] I Heard You Like Bullet Hells | 1 | |
| 43. | Fante | old greedy judas | 1 | |
| 44. | Goldfeel Music | The Binding Of Isaac Soundtrack But With A Pipe Organ | 1 | |
| 45. | Fante | slow dodging in the dark | 1 | |
| 46. | DIX | LIVE !!! | 1 | |
| 47. | Bocherz | A Better Brimstone | 1 | |
| 48. | Fante | [Nutshell] TBoI: Greed Mode | 1 | |
| 49. | Fante | regret pedestals | 1 | |
| 50. | Bocherz | Unlocking Godhead The Experience #twitch #gaming #bindingofisaac #repentance #thelost | 1 | |
| 51. | Fante | [Trial] The Binding of Isaac: Godmode v4.0.1 | 1 | |
