| 1. | World of Longplays | 41,670 | NES Longplay [638] Toxic Crusaders | 38:40 |
| 2. |  NintendoComplete | 22,131 | Toxic Crusaders (Genesis) Playthrough - NintendoComplete | 51:22 |
| 3. |  A & C Games | 19,692 | Toxic Crusaders NES Deathless Complete Playthrough - Part 3 | 9:21 |
| 4. | DarkEvil87's Longplays | 6,000 | Toxic Crusaders - DarkEvil87's Longplays - Full Longplay (NES) | 31:39 |
| 5. |  The Mexican Runner | 1,840 | 139/714 Toxic Crusaders - NESMania | 2:08:32 |
| 6. |  Longplay Center | 670 | Toxic Crusaders (Genesis) Playthrough [4K] | 44:04 |
| 7. |  Reinc | 582 | Toxic Crusaders (NES) full playthrough | 38:40 |
| 8. | TheInnocentSinful | 406 | Toxic Crusaders (PC) Demo Playthrough | 17:12 |
| 9. | OnlyLevelOne | 307 | Toxic Crusaders - NES - Only Level One | 7:06 |
| 10. | Waffle Bros | 265 | WILL THIS BE THE GROSSEST GAME EVER??? | Let's Play Toxic Crusaders (Nextfest Demo) | 19:22 |
| 11. | Media Pool | 194 | Toxic Crusaders (Genesis) Playthrough longplay video game | 57:18 |
| 12. | 10 Minute Gamer | 162 | 10MG Plays Toxic Crusaders on NES | 4:55 |
| 13. | Eric Corp Incorporated | 147 | Toxic Crusaders (Genesis / Mega Drive) Playthrough | 58:48 |
| 14. |  Esh Plays | 145 | Toxeriffic! | Esh Plays TOXIC CRUSADERS (Demo) | 26:51 |
| 15. | MEGADAN29 | 78 | Toxic Crusaders Playthrough 1 cc Sega Genesis | 49:54 |
| 16. |  BRGKasumi77 MAIN CHANNEL | 63 | Toxic Crusaders (NES) Playthrough with cheats | 32:14 |
| 17. | STUNT_MK | 52 | Good&Evil Gaming! Let's Play "Toxic Crusaders"! | 5:26 |
| 18. | Super Omnibox | 51 | Random Retro Roulette ~ The Games Were Inside Us All Along | 1:11:46 |
| 19. | TurtlePizzaPower's Gaming & Entertainment | 51 | Toxic Crusaders (2023) - Full Demo Playthrough (4KHD) | 18:29 |
| 20. | Toxcyn | 49 | Toxin Plays Toxic Crusader Demo! | 9:31 |
| 21. | Mr. Killa KareBear | 48 | Mr. KKB Plays Next Fest 2023 - Toxic Crusaders Demo Ep.2 | 27:38 |
| 22. | WarriorsOfXalnada | 47 | Toxic Crusaders Nes Nintendo Full Playthrough | 38:40 |
| 23. | Tudututu | 35 | Beat them with the help of radioativity | Toxic Crusaders | 21:34 |
| 24. |  Black_Stark2 | 27 | A Cartoonish and Action-packed Couch Co-op Beat 'em Up | Toxic Crusaders demo | 25:48 |
| 25. |  Kiss My Robot | 26 | Toxic Crusaders (2023) - PC Demo - Full Playthrough | 20:06 |
| 26. | EctogamesTV | 21 | Toxic Crusaders Demo | Full Playthrough | 2 | 40:31 |
| 27. | SantaAzulCTZN | 20 | Toxic Crusaders Demo Playthrough | 20:43 |
| 28. | PlayDHDGaming | 14 | Toxic Crusaders Demo Playthrough | 21:03 |
| 29. | Geeks and Nerds | 8 | Pablo Plays - Toxic Crusaders (Demo) | 18:49 |
