AIDS/HIV: Developed treatment that can completely eradicate the virus
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US scientists signed an important study against AIDS/HIV, which 38 million people worldwide suffer from. Thanks to the "kick and kill" method, the virus in the infected cells was targeted and the immune system was activated. Thus, complete removal of HIV from the body, which could not be achieved with the currently applied treatments, was accomplished. Scientists said the new treatment, which is currently in animal testing, will be a turning point in the fight against AIDS.
Scientists from the University of California Los Angeles (UCLA) in the USA have developed a treatment method that forces the HIV virus out of the cells and leaves it vulnerable to the natural immune response.
The results of the research, published in the scientific journal Nature Communications, raised hopes in the fight against AIDS.
VIRUS FULLY REMOVED IN 40 PERCENT OF MICE
In laboratory tests on 10 mice, the new approach was found to eliminate the HIV virus in 40 percent of cases.
36 MILLION PEOPLE HAVE DIE IN THE LAST 10 YEARS
However, according to the United Nations (UN), an estimated 38 million people worldwide are currently living with HIV, and the virus has caused 36 million deaths in the past decade.
CAN AVOID ADDICTION TO ANTIRETROVIRAL DRUGS
If the new treatment method proves to be safe and effective in humans, it could eliminate the need for people with HIV to continue to be dependent on antiretroviral drugs.
The study was done by infectious disease specialist Jocelyn Kim of UCLA and colleagues.
Commenting on the subject, Dr. "These findings remove what has for many years been seen as an almost insurmountable challenge to potentially eliminate HIV from the body. The study opens a new paradigm for a possible future HIV treatment," said Kim.
On the other hand, currently, people with HIV take antiretroviral drugs that, instead of killing the virus, stop its spread at various stages of its "life cycle" (such as when a host cell enters or spreads).
While the drugs in question can suppress the virus to the extent that the host's viral load becomes both undetectable and nontransmissible, HIV remains dormant in their system, hiding in CD4+ T cells that normally help coordinate immune responses.
"KICK AND KILL"
When people with HIV stop taking antiretroviral therapy, the virus can escape and continue to replicate in the body. This weakens the immune system, increasing the risk of deadly cancer and infection.
In UCLA's new method, called "kick and kill," HIV was targeted and eliminated in infected cells.
The study's authors found that treatment with an antiretroviral from HIV-infected mice, whose immune systems were modified to match that of humans, inactivated 25 percent of infected cells within 24 hours.
Searching for a more effective way to destroy infected cells, researchers turned instead to natural killer cells produced by the body's immune system, which, as the name suggests, can kill infected or tumor cells.
By injecting healthy natural killer cells with SUW133, which clears HIV from its hiding place, the team was able to completely clear HIV in 4 out of 10 infected mice.
The researchers took particular care in analyzing the spleens of mice, as it is known that HIV can remain dormant and harbor immune cells such as CD4+ T cells.
NEXT STAGE PEOPLE
Once their initial work is complete, the researchers are looking to refine their approach so that they succeed in eradicating HIV in 100 percent of mouse cohorts in future experiments.
Dr. "We will also move this research towards preclinical studies in non-human primates, whose ultimate goal is to test the same approach in humans," said Kim. nonstop news
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