Game:

Altered Beast (2005)

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Altered Beast was released in Europe for the PlayStation 2 on February 25, 2005.

This is a reimagining of the Arcade/Sega Genesis/Mega Drive game. It's an even more generic beat'em up than what it's based on. It strips away the mystical/fantasy trappings of the original game, and replaces it with a modern day setting and science. The concept is interesting but the execution is less than good.

from wikipedia:

A Special Forces helicopter carrying a mysterious sarcophagus-like box labeled "United States Gene Research" approaches Foret Town, a city that has been covered in a mutagenic mist and turned into a quarantine zone. Suddenly, a monster resembling a griffin takes down the helicopter. In the wreckage, from the sarcophagus emerges a man with no memories, Luke Custer, who finds an information file about "Project Altered Beast" before being attacked by mutants. Luke's self-preservation instinct triggers, transforming him into a huge werewolf who kills the monsters before collapsing. A woman approaches, explaining that the transformation causes huge physical and mental stress, and injecting Luke with tranquilizer to revert him to human form. However, Luke is unable to remember who she is due to amnesia, much to her surprise. She gives him short lectures about the effect of his transformation before leaving Luke.