biosights: February 16, 2015 - Filopodia point the way for haptotaxis

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Published on ● Video Link: https://www.youtube.com/watch?v=8UExeo1IDxs


Duration: 3:04
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DescriptionMigrating fibroblasts maintain or change their direction by branching off new lamellipodia from existing protrusions at the cell's leading edge. Johnson et al. reveal that filopodial protrusions initiate and orient these lamellipodia, helping fibroblasts navigate gradients of immobilized guidance cues. This biosights episode presents the paper by Johnson et al. from the February 16, 2015, issue of The Journal of Cell Biology and includes an interview with the paper's senior author, Jason Haugh (North Carolina State University, Raleigh, NC). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.

See Johnson et al.: http://jcb.rupress.org/content/208/4/443.full



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Tags:
JCB
Journal of Cell Biology
Rockefeller University Press