The cytokinetic cleavage furrow must be carefully aligned with the spindle midzone during asymmetric cell division. Pacquelet et al. discover a pathway that maintains the connection between spindle and furrow position in one-cell C. elegans embryos by inhibiting the accumulation of myosin at the anterior cortex during cytokinesis. This biosights episode presents the paper by Pacquelet et al. from the September 28, 2015, issue of The Journal of Cell Biology and includes an interview with the paper's corresponding author, Anne Pacquelet (Centre National de la Recherche Scientifique and Institut de Génétique et Développement de Rennes, France). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.
1