biosights: March 16, 2015 - PAPC separates tissues at a Snail's pace

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Published on ● Video Link: https://www.youtube.com/watch?v=AVDlzOj53QI


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Brachet's cleft separates the ectoderm and mesoderm of early Xenopus and zebrafish embryos. Luu et al. reveal that, in conjunction with the transcription factor Snail1, the protocadherin PAPC promotes tissue separation by down-regulating planar cell polarity proteins at the ectoderm-mesoderm boundary. This biosights episode presents the paper by Luu et al. from the March 16, 2015, issue of The Journal of Cell Biology and includes an interview with one of the paper's senior authors, Rudolf Winklbauer (University of Toronto, Toronto, Canada). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.

See Luu et al.: http://jcb.rupress.org/content/208/6/839.full



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JCB
Journal of Cell Biology
Rockefeller University Press