biosights: February 20, 2012 - Neuronal autophagosomes mature on the move

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Published on ● Video Link: https://www.youtube.com/watch?v=iQeCmtZHzyg


Duration: 8:24
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Autophagy is a cellular degradation pathway essential for neuronal survival, but little is known about the dynamics of autophagic organelles in neurons. Maday et al. reveal that autophagosomes form and engulf cargo at the distal tips of neurites and then mature into degradative autolysosomes as they move toward the cell body. This biosights episode presents the paper by Maday et al. from the February 20, 2012, issue of The Journal of Cell Biology and includes an interview with authors Sandra Maday and Erika Holzbaur (University of Pennsylvania, Philadelphia). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.

Read the related article online at: http://jcb.rupress.org/content/196/4/407.full



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Tags:
biosights
JCB
Rockefeller University Press
Journal of Cell Biology
autophagy
organelles
neurons
degradative autolysosomes