Dante's Inferno - skipping Lady Fortuna
Another very neat skip, though I fear it is not compatible with the Plutus Chamber skip. I think you could do a variation of this skip *during* Lady Fortuna, since you re-visit this place, but the saved time wouldn't be as impressive (and in a speedrun, how can you afford the redemption?).
This one goes straight from Plutus Chamber to Sins of the Father, sparing you 3 fights (of which one is a boss fight), some platforming, a long beast ride section (remember the beast ride block puzzle? yeah...) and a few cutscenes. Overall, a skip which saves over 5 minutes? Haven't tested yet.
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Dante's Inferno glitch FAQ
http://www.gamefaqs.com/ps3/955368-dantes-inferno/faqs/63608
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