Dark Heresy RPG : Pyrebrand - Setting, Stories & Characters
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Dark Heresy is an RPG set in the Warhammer 40,000 universe. It is to 40k as Warhammer Fantasy Roleplay is to Warhammer Fantasy Battle, and indeed uses a very similar system.
Basically you're fucked like in WFRP, only instead of dying from blood poisoning caused by a dirty pitchfork you get to have your innards blown across the wall and then subsequently set on fire by a plasma gun (probably your own). This is if you are lucky. All kinds of worse things can happen - being eaten by xenos or hungry daemons, afflicted by Chaos mutation, and if you are especially unfortunate... *gulp* ...surviving to reach Inquisitorhood. It has the best critical hit charts ever made. You don't even need the rest of the game (although it is all good, it's just a LOT). Just start a campaign, wing it, and whenever anyone gets a good hit, roll on the critical hit charts. Holy fucking hell, did boiling bone marrow just turn my femur into a frag grenade? Fuck.
All player characters are supposed to be human acolytes working for the Inquisition, although they may come from many different vocations. From the feral world warrior to the hive ganger, from the inducted Guardsman to the detached Sister of Battle. However, whilst the official adventures focus on inquisitorial investigations, the authors themselves have acknowledged the ease of relocating the game's focus to other aspects of the 41st millennium, such as an Imperial Guard platoon where all player characters are soldiers in one of the many warzones.