From Selective Cardiovascular Cells Adhesion to Regulating “Spatiotemporal Orderliness of Function”
From Selective Cardiovascular Cells Adhesion to Regulating “Spatiotemporal Orderliness of Function”: Understanding based on Biomaterials Surface Modification with Functional Molecules
Conjugating functional molecules onto the cardiovascular biomaterials surface to obtain the selective cell adhesion is the mainstream strategy currently. The concept of authority is more inclined to promote endothelial cells (EC) to grow directly on the materials surface but inhibit smooth muscle cells (SMC) growth. However, our recent research discovered that EC might not directly contact the implants surface at all, and the endothelial monolayer formed depended on the contractile SMC, and macrophages of M2 phenotype contributed to inducing contractile SMC to cover the biomaterials surface. Here, we proposed a concept of “spatiotemporal orderliness of function”, aiming at revealing the interaction of cardiovascular cells and the biomaterials surface during the formation of endothelial monolayer. This novel concept is anticipated to contribute to the surface design of new generation cardiovascular implant materials.
#Cells adhesion #conjugatingfunctionalmolecules #cardiovascularbiomaterials
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https://bp.bookpi.org/index.php/bpi/catalog/book/270