Isaac vs Gemini - Boss Battle - Playthrough (4K 60FPS) | The Binding of Isaac
0"The larger of the two will walk towards Isaac, trying to deal contact damage. Eventually, he starts charging with increased speed for few seconds. Right after charging, he runs out of breath and has to stop, leaving him vulnerable to attack. The smaller one drifts along at a distance, and will fire fast-moving blood shots at Isaac if he comes near and isn't behind cover. The umbilical cord acts like an elastic tether, keeping them in roughly the same area while not restricting range of movement too much.
Killing the larger twin will cause the smaller one to turn incredibly red when becoming enraged, abandoning ranged attacks in favor of charging at Isaac (if the player deliberately focus-fire the small one from the start, it will be killed and they only have to focus on the big one, whose behavior will not change). While enraged, the smaller twin takes a lot more knockback, which can be troublesome if care is not taken.
Strategies
The character's best option for handling these two is to run around the edges of the room, firing behind them as they go. Gemini's speed is usually not sufficient to reach Isaac, making him easy to fight.
Movement-controlling items like Mom's Bra and Mom's Pad can be helpful if the character find themselves unable to stay ahead of the larger twin's frequent charges. Strong explosive attacks like Bombs are easy to land when the large twin stops for breath.
Due to the knockback from tears, it is possible to keep Suture completely stationary if you got him to run at you parallel to a wall and your tears were being fired straight at him, without influence from movement.
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