LATEST NEWS: COVID-19: APPROVED: AVIGAN FABIFLU FAVIPIRAVIR TREATMENT FOR CORONA VIRUS | CHINA INDIA
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WHAT IS AVIGAN | FAVIPIRAVIR ANTIVIRAL DRUG BY FUJIFILM TOYAMA CHEMICAL
IS IT EFFECTIVE FOR CORONA VIRUS - COVID 19?
WHAT IS AVIGAN | FAVIPIRAVIR ANTIVIRAL DRUG BY FUJIFILM | IS IT EFFECTIVE FOR CORONA VIRUS COVID-19?
APPROVED: IS AVIGAN | FAVIPIRAVIR | T-705 | FAVILAVIR BY FUJIFILM EFFECTIVE?
Favipiravir, also known as T-705, Avigan, or favilavir is an antiviral drug being developed by Toyama Chemical (Fujifilm group) of Japan with activity against many RNA viruses.
In 2014, Japan approved Favipiravir for treating viral strains unresponsive to current antivirals.
In March 2015, the US Food and Drug Administration completed a Phase III clinical trial into the safety and efficacy of Favipiravir in the treatment of influenza.
On 15 March 2020 the drug was approved in China with the name Favilavir for the treatment of influenza.The drug was also approved for use in clinical trials for treating coronavirus disease 2019 pneumonia.
On 22 March 2020 Italy has approved the drug for experimental use against COVID-19 and has begun conducting trials in 3 regions most affected by the disease. The Italian Pharmaceutical Agency, however, has reminded the public that the existing evidence in support of this drug is scant and preliminary.
On 17 March 2020, Chinese officials suggested that Favipiravir seemed to be effective in treating COVID-19 in Wuhan and Shenzhen.
A study on 80 patients comparing it to lopinavir/ritonavir found that it significantly reduced viral clearance time to 4 days, compared to 11 days for the control group, and that 91.43% of patients had improved CT scans with few side effects. The limitation of this study is that it was not a randomized double-blinded placebo-controlled clinical trial.
Favipiravir
Chinese clinical trials in Wuhan and Shenzhen claimed to show favipiravir was "clearly effective". Of 35 patients in Shenzhen tested negative in a median of 4 days, while the length of illness was 11 days in the 45 patients who did not receive it. In a study conducted in Wuhan on 240 patients with pneumonia half were given favipiravir and half received umifenovir. The researchers found that patients recovered from coughs and fevers faster when treated with favipiravir, but there was no change in how many patients in each group progressed to more advanced stages of illness (treatment with a ventilator).
On 22 March, Italy approved the drug for experimental use against COVID-19 and began conducting trials in the three regions most affected by the disease. The Italian Pharmaceutical Agency reminded the public that the existing evidence in support of the drug is scant and preliminary. On 2 April, Germany announced that it would purchase the drug from Japan for its stockpile, and use the military to deliver the drug to university hospitals, where the drug will be used to treat COVID-19 patients. According to the South China Morning Post, Shinzo Abe has made overtures to the Trump administration about purchasing the drug.
The drug may be less effective in severe cases of illness where the virus has already multiplied. It may not be safe for use by pregnant women or those trying to conceive.
UPDATE:
On 15 March 2020, the drug was approved in China for the treatment of Covid-19.On 20 June 2020, the drug was approved in India for the treatment of Covid-19 patients under the brand name of Fabiflu manufactured by Glenmark. In India the drug is priced at Rs 103 per tablet.
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