Like a Dragon: Ishin! - Part 51: Substory 15: The Injured Grandma & Bond
If you head to the riverbank in Teramachi in Chapter 4, you'll spot an elderly lady on the ground! Help her out and you'll take her home and clear the substory.
Return later and she'll need a bit of help shopping, starting with some Ointment, she'll give you 2,500 mon, far more than the 300 mon the item costs at the nearby Don Quijote!
Later, she'll want some All-Purpose Medicine and give you 2,500 mon, the item itself costs 2,000 mon at the Apothecary.
Finally, she'll want some Yokan and give you 1,000 mon, the item costs 500 mon at Don Quijote.
Return one last time after this to max out her friendship bar, after that, you can come back to talk to her for a bit of Virtue when you pass by.
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